XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.

Based on structural and evolutionary criteria, neuropeptide Y (NPY)b, peptide YY (PYY) and pancreatic polypetide (PP) are closely related polypeptides ([Larhammar, 1996a][1]). They are composed of 36 amino acids each and share considerable amino acid homology, amidated C-terminal ends, and the

[1]  V. Montel,et al.  In vitro steroidogenic effects of neuropeptide Y (NPY1–36), Y1 and Y2 receptor agonists (Leu31-Pro34 NPY, NPY18–36) and peptide YY (PYY) on rat adrenal capsule/zona glomerulosa , 1994, Regulatory Peptides.

[2]  D. Reis,et al.  Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem. , 1991, The Journal of pharmacology and experimental therapeutics.

[3]  R. Patterson,et al.  Coronary constriction due to neuropeptide Y: alleviation with cyclooxygenase blockers. , 1989, The American journal of physiology.

[4]  W. Rascher,et al.  Neuropeptide Y: a possible role in hypertension? , 1995, Journal of hypertension.

[5]  R. Duman,et al.  Sequence and expression of a neuropeptide Y receptor cDNA. , 1991, Molecular pharmacology.

[6]  R. North,et al.  Coexpression with potassium channel subunits used to clone the Y2 receptor for neuropeptide Y. , 1996, Molecular pharmacology.

[7]  W. Colmers,et al.  Effects of neuropeptide Y on the electrical properties of neurons , 1994, Trends in Neurosciences.

[8]  J. Fuhlendorff [Leu^ , Pro^ ]neuropeptide Y : a specific Y1 receptor agonist , 1990 .

[9]  K. Kodukula,et al.  Cloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y Receptor (*) , 1995, The Journal of Biological Chemistry.

[10]  N. Ishikawa,et al.  Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema. , 1996, European journal of pharmacology.

[11]  C. Strader,et al.  Cloning and Expression of a Novel Neuropeptide Y Receptor* , 1996, The Journal of Biological Chemistry.

[12]  G. Koob,et al.  Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. , 1993, Science.

[13]  H. Motulsky,et al.  Distinction of NPY receptors in vitro and in vivo. I. NPY-(18-36) discriminates NPY receptor subtypes in vitro. , 1990, The American journal of physiology.

[14]  H. Monyer,et al.  Molecular cloning of a novel G protein‐coupled receptor that may belong to the neuropeptide receptor family , 1990, FEBS letters.

[15]  S. Sheikh Neuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function. , 1991, The American journal of physiology.

[16]  F. Oury-Donat,et al.  SR120819A, an orally‐active and selective neuropeptide Y Y1 receptor antagonist , 1995, FEBS letters.

[17]  H. Wieland,et al.  Receptor binding profiles of NPY analogues and fragments in different tissues and cell lines , 1995, Peptides.

[18]  J. Leban,et al.  High-affinity neuropeptide Y receptor antagonists. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[19]  T. Westfall,et al.  Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. , 1995, European journal of pharmacology.

[20]  S. Tam,et al.  Neuropeptide Y and peptide YY do not bind to brain σ and phencyclidine binding sites , 1991 .

[21]  Herbert Herzog,et al.  Multiple Promoters Regulate Tissue-specific Expression of the Human NPY-Y1 Receptor Gene (*) , 1995, The Journal of Biological Chemistry.

[22]  K. Rudolf,et al.  Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. , 1995, The Journal of pharmacology and experimental therapeutics.

[23]  J. Lundberg Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. , 1996, Pharmacological reviews.

[24]  Yun Feng,et al.  Molecular Characterization of a Second Mouse Pancreatic Polypeptide Receptor and Its Inactivated Human Homologue* , 1996, The Journal of Biological Chemistry.

[25]  Terry D. Lee,et al.  A new molecular form of PYY: Structural characterization of human PYY(3–36) and PYY(1–36) , 1989, Peptides.

[26]  S. Brenner,et al.  Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[27]  B. McDermott,et al.  Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes. , 1991, The American journal of physiology.

[28]  Yun Feng,et al.  Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family , 1996, FEBS letters.

[29]  R. Miller,et al.  Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Petitto,et al.  Molecular cloning of NPY-Y1 receptor cDNA from rat splenic lymphocytes: Evidence of low levels of mRNA expression and [125I]NPY binding sites , 1994, Journal of Neuroimmunology.

[31]  Daniel Grandt,et al.  Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV , 1993, Regulatory Peptides.

[32]  J. Wharton,et al.  Expression of the human neuropeptide tyrosine Y1 receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[33]  H. Herzog,et al.  Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. , 1993, The Journal of biological chemistry.

[34]  H. Motulsky,et al.  Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells. , 1988, The American journal of physiology.

[35]  P. Layer,et al.  Novel generation of hormone receptor specificity by amino terminal processing of peptide YY. , 1992, Biochemical and biophysical research communications.

[36]  F. Sundler,et al.  FP, PYY, and NPY: Occurrence and Distribution in the Periphery , 1993 .

[37]  P. Layer,et al.  [Pro34]peptide YY is a Y1-selective agonist at peptide YY/neuropeptide Y receptors. , 1994, European journal of pharmacology.

[38]  W. Rascher,et al.  Neuropeptide Y (NPY) receptors in HEL cells: comparison of binding and functional parameters for full and partial agonists and a non‐peptide antagonist , 1992, British journal of pharmacology.

[39]  R. Quirion,et al.  Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type. , 1994, Brain research. Molecular brain research.

[40]  T. Hökfelt,et al.  Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  D. Larhammar,et al.  The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[42]  X. J. Li,et al.  Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. , 1992, The Journal of biological chemistry.

[43]  D. Larhammar,et al.  Cloning of a Human Receptor of the NPY Receptor Family with High Affinity for Pancreatic Polypeptide and Peptide YY (*) , 1995, The Journal of Biological Chemistry.

[44]  T. Hexum,et al.  Neuropeptide Y inhibition of nicotinic receptor-mediated chromaffin cell secretion. , 1994, The Journal of pharmacology and experimental therapeutics.

[45]  R. Bleackley,et al.  In Vivo Regulation of Murine Granzyme B Gene Transcription in Activated Primary T Cells* , 1996, The Journal of Biological Chemistry.

[46]  Yinghe Hu,et al.  Identification of a Novel Hypothalamic Neuropeptide Y Receptor Associated with Feeding Behavior* , 1996, The Journal of Biological Chemistry.

[47]  D. Larhammar,et al.  Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. , 1996, Molecular pharmacology.

[48]  T. Perney,et al.  Two different G-proteins mediate neuropeptide Y and bradykinin-stimulated phospholipid breakdown in cultured rat sensory neurons. , 1989, The Journal of biological chemistry.

[49]  W. Rascher,et al.  Neuropeptide Y 3–36 is an endogenous ligand selective for Y2 receptors , 1996, Regulatory Peptides.

[50]  R. Sprengel,et al.  The murine NPY‐1 receptor gene Structure and delineation of tissue‐specific expression , 1992, FEBS letters.

[51]  H. Akiho,et al.  Inactivation of a Novel Neuropeptide Y/Peptide YY Receptor Gene in Primate Species* , 1996, The Journal of Biological Chemistry.

[52]  T. Branchek,et al.  Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype (*) , 1995, The Journal of Biological Chemistry.

[53]  R. Playford,et al.  Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte homeostasis. , 1996, Trends in pharmacological sciences.

[54]  D. Larhammar,et al.  Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. , 1992, The Journal of biological chemistry.

[55]  T. Branchek,et al.  Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY (*) , 1995, The Journal of Biological Chemistry.

[56]  D. Larhammar Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide , 1996, Regulatory Peptides.

[57]  D. Johnson,et al.  Expression cloning of a human brain neuropeptide Y Y2 receptor , 1996, Regulatory Peptides.

[58]  B. Martin,et al.  Neuropeptide Y and peptide YY interact with rat brain σ and PCP binding sites , 1989 .

[59]  R. Eglen,et al.  Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist. , 1995, The Journal of pharmacology and experimental therapeutics.

[60]  W. Colmers,et al.  Presynaptic inhibition by neuropeptide Y and baclofen in hippocampus: insensitivity to pertussis toxin treatment , 1989, Brain Research.

[61]  P. Seeburg,et al.  Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. , 1992, Molecular pharmacology.

[62]  L. Limbird Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[63]  C. Wahlestedt,et al.  Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides , 1986, Regulatory Peptides.

[64]  K. Rudolf,et al.  BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: A review of its pharmacological properties , 1996, Regulatory Peptides.

[65]  T. Schwartz,et al.  [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[66]  M. Michel,et al.  Receptor subtypes Y1 and Y5 are involved in the renal effects of neuropeptide Y , 1997, British journal of pharmacology.

[67]  D. Larhammar Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide , 1996, Regulatory Peptides.

[68]  D. Larhammar,et al.  Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevis. , 1995, Biochimica et biophysica acta.

[69]  C. Beglinger,et al.  Two molecular forms of Peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1–36 and PYY 3–36 , 1994, Regulatory Peptides.

[70]  P. J. Larsen,et al.  Regional Distribution of Putative NPY Y1 Receptors and Neurons Expressing Y1 mRNA in Forebrain Areas of the Rat Central Nervous System , 1993, The European journal of neuroscience.

[71]  Takao Shimizu,et al.  Identification of Two Isoforms of Mouse Neuropeptide Y-Y1 Receptor Generated by Alternative Splicing , 1995, The Journal of Biological Chemistry.

[72]  S. Whitebread,et al.  A receptor subtype involved in neuropeptide-Y-induced food intake , 1996, Nature.

[73]  J. Shine,et al.  Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. , 1993, DNA and cell biology.

[74]  S. Bloom,et al.  Evidence of a paracrine role of neuropeptide-Y in the regulation of insulin release from pancreatic islets of normal and dexamethasone-treated rats. , 1994, Endocrinology.

[75]  B. Earley,et al.  Central nervous system pharmacology of neuropeptide Y. , 1995, Pharmacology & therapeutics.

[76]  D. Larhammar,et al.  A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells , 1993, Regulatory Peptides.

[77]  Anders,et al.  Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. , 1992, The Journal of biological chemistry.