One-Pot, Three-Component Condensation of Aldehydes, 2-Naphthol and 1,3-Dicarbonyl Compounds

A practical and efficient procedure for the one-pot multicomponent couping of aryl aldehydes, 2-naphthol and cyclic 1,3-dicarbonyl compounds using perchloric acid adsorbed on silica gel (HClO 4 -SiO 2 ) as a highly efficient, inexpensive, convenient, reusable heterogeneous catalyst under solvent-free conditions has been developed. Various biologically important 12-aryl-8,9,10,12-tetrahydrobenzo[α]xanthen-11-one derivatives have been efficiently synthesized in high to excellent yields. The present approach offers several advantages such as shorter reaction times, simple work-up, excellent yields, low cost, and mild reaction conditions. Furthermore, the catalyst can be recovered simply and reused without appreciable loss of its catalytic activity.

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