Erythropoietin prevents delayed hemodynamic dysfunction after subarachnoid hemorrhage in a randomized controlled experimental setting

[1]  E. Barbier,et al.  Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative* , 2011, Critical care medicine.

[2]  S. Mayer,et al.  Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2) , 2011, The Lancet Neurology.

[3]  J. Dreier The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease , 2011, Nature Medicine.

[4]  V. Seifert,et al.  Perfusion–diffusion mismatch in MRI to indicate endovascular treatment of cerebral vasospasm after subarachnoid haemorrhage , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[5]  Asla Pitkänen,et al.  Magnetic Resonance Imaging of Regional Hemodynamic and Cerebrovascular Recovery after Lateral Fluid-Percussion Brain Injury in Rats , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  John H. Zhang,et al.  Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury , 2010, Molecular Neurobiology.

[7]  L. Velly,et al.  Erythropoietin 2nd cerebral protection after acute injuries: a double-edged sword? , 2010, Pharmacology & therapeutics.

[8]  Gang Chen,et al.  Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway. , 2010, Cytokine.

[9]  D. Laskowitz,et al.  Neuroprotection in subarachnoid hemorrhage. , 2010, Stroke.

[10]  S. Mayer,et al.  Preventing Vasospasm Improves Outcome After Aneurysmal Subarachnoid Hemorrhage: Rationale and Design of CONSCIOUS-2 and CONSCIOUS-3 Trials , 2010, Neurocritical care.

[11]  J. Fandino,et al.  Standard intracranial in vivo animal models of delayed cerebral vasospasm , 2010, British journal of neurosurgery.

[12]  P. Raab,et al.  Histological evidence of delayed ischemic brain tissue damage in the rat double-hemorrhage model , 2010, Journal of the Neurological Sciences.

[13]  M. Digicaylioglu Erythropoietin in stroke: quo vadis , 2010, Expert opinion on biological therapy.

[14]  L. Solymosi,et al.  Prophylactic intravenous magnesium sulfate for treatment of aneurysmal subarachnoid hemorrhage: A randomized, placebo-controlled, clinical study* , 2010, Critical care medicine.

[15]  R. Macdonald Erythropoietin: will it improve outcome after subarachnoid hemorrhage? , 2010, World neurosurgery.

[16]  C. Prestigiacomo,et al.  Erythropoietin for the treatment of subarachnoid hemorrhage: a review. , 2010, World neurosurgery.

[17]  Michael Nilsson,et al.  A Systematic Review and Meta-Analysis of Erythropoietin in Experimental Stroke , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  J. Yrjänheikki,et al.  Cerebral Blood Volume Alterations in the Perilesional Areas in the Rat Brain after Traumatic Brain Injury—Comparison with Behavioral Outcome , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  K. Inaba,et al.  Erythropoiesis Stimulating Agent Administration Improves Survival After Severe Traumatic Brain Injury: A Matched Case Control Study , 2010, Annals of surgery.

[20]  H. Reichmann,et al.  Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke , 2009, Stroke.

[21]  E. Titova,et al.  Experimental models of subarachnoid hemorrhage for studies of cerebral vasospasm , 2009, Neurological research.

[22]  J. Pickard,et al.  Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article. , 2009, Journal of neurosurgery.

[23]  E. Keller,et al.  Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought , 2009, Neurological research.

[24]  Ji-Xin Shi,et al.  Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. , 2009, Cytokine.

[25]  Ting-Yim Lee,et al.  Hemodynamic effects of recombinant human erythropoietin on the central nervous system after subarachnoid hemorrhage: reduction of microcirculatory impairment and functional deficits in a rabbit model. , 2008, Journal of neurosurgery.

[26]  F. Groenendaal,et al.  Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia , 2008, Brain Research Reviews.

[27]  A. Cerami,et al.  Erythropoietin‐mediated tissue protection: reducing collateral damage from the primary injury response , 2008, Journal of internal medicine.

[28]  S. Mayer,et al.  Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1): Randomized, Double-Blind, Placebo-Controlled Phase 2 Dose-Finding Trial , 2008, Stroke.

[29]  H. H. Marti,et al.  Brain protection by erythropoietin: a manifold task. , 2008, Physiology.

[30]  M. Spedding,et al.  Drugs in sport: a scientist–athlete's perspective: from ambition to neurochemistry , 2008, British journal of pharmacology.

[31]  R. De Gaudio,et al.  Carbamylated erythropoietin is neuroprotective in an experimental model of traumatic brain injury , 2008, Critical care medicine.

[32]  O. Jørgensen,et al.  Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: a double blind randomised clinical trial , 2007, Acta Neurochirurgica.

[33]  T. Fabian,et al.  Efficacy and safety of epoetin alfa in critically ill patients. , 2007, The New England journal of medicine.

[34]  C. Segebarth,et al.  Erythropoietin Protects from Post-Traumatic Edema in the Rat Brain , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  C. Preibisch,et al.  CHARACTERIZATION OF THE ENDOTHELIN‐B RECEPTOR EXPRESSION AND VASOMOTOR FUNCTION DURING EXPERIMENTAL CEREBRAL VASOSPASM , 2007, Neurosurgery.

[36]  A. Demchuk,et al.  Role of transcranial Doppler in neurocritical care , 2007, Critical care medicine.

[37]  C. Preibisch,et al.  PERSISTENCE OF THE NITRIC OXIDE‐DEPENDENT VASODILATOR PATHWAY OF CEREBRAL VESSELS AFTER EXPERIMENTAL SUBARACHNOID HEMORRHAGE , 2007, Neurosurgery.

[38]  John H. Zhang,et al.  Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  R. Macdonald,et al.  Can angiographic vasospasm be used as a surrogate marker in evaluating therapeutic interventions for cerebral vasospasm? , 2006, Neurosurgical focus.

[40]  F. Zanella,et al.  Time Course in the Development of Cerebral Vasospasm after Experimental Subarachnoid Hemorrhage: Clinical and Neuroradiological Assessment of the Rat Double Hemorrhage Model , 2006, Neurosurgery.

[41]  J. Stubbs Alternatives to blood product transfusion in the critically ill: Erythropoietin , 2006, Critical care medicine.

[42]  H. Ehrenreich,et al.  The Brain Erythropoietin System and its Potential for Therapeutic Exploitation in Brain Disease , 2006, Journal of neurosurgical anesthesiology.

[43]  J. Roh,et al.  Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage , 2006, Journal of neurochemistry.

[44]  R. Macdonald Management of cerebral vasospasm , 2006, Neurosurgical Review.

[45]  M. Wintermark,et al.  Comparative overview of brain perfusion imaging techniques. , 2005, Stroke.

[46]  C. Berde,et al.  The Effects of Lidocaine and Adrenergic Agonists on Rat Sciatic Nerve and Skeletal Muscle Blood Flow In Vivo , 2002 .

[47]  P. Lewczuk,et al.  Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial , 2002, Molecular medicine.

[48]  Hans-Jörg Wittsack,et al.  Benutzerfreundliche Auswertung von MR-Untersuchungen der zerebralen Perfusion: Windows®-basierte Bildverarbeitung , 2002 .

[49]  F. Tomasello,et al.  Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  O. Paulson,et al.  A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid haemorrhage in rats , 2002, British journal of pharmacology.

[51]  P. Lewczuk,et al.  Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[52]  G. Grasso,et al.  Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage. , 2001, Journal of neurosurgical sciences.

[53]  P Ghezzi,et al.  Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. Soehle,et al.  Postischemic application of lipid peroxidation inhibitor U-101033E reduces neuronal damage after global cerebral ischemia in rats. , 1998, Stroke.

[55]  Aman B Patel,et al.  Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association , 1994, Stroke.

[56]  L. Pitts,et al.  Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. , 1986, Stroke.

[57]  H. Ehrenreich,et al.  Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system , 2011, Neurotherapeutics.

[58]  G. Zoppo Microvascular changes during cerebral ischemia and reperfusion. , 1994 .

[59]  D. Heistad,et al.  Regulation of large cerebral arteries and cerebral microvascular pressure. , 1990, Circulation research.