论文信息 - MetaGeneAlyse: analysis of integrated transcriptional and metabolite data

MetaGeneAlyse: analysis of integrated transcriptional and metabolite data

UNLABELLED New techniques in sample preparation allow high throughput analysis of samples on the transcriptional as well as on the metabolic level. We present a service accessible via the web that allows the analysis of integrated data sets that combine gene-expression data and metabolic data. After uploading, data sets can be normalized, clustered by various methods and results can be graphically visualized. All calculations are carried out on a server, so even time- and memory-consuming analyses can be done independently of the performance of the client. AVAILABILITY The service is accessible via web-interface at http://metagenealyse.mpimp-golm.mpg.de/

[1] O. Fiehn,et al. Metabolite profiling for plant functional genomics , 2000, Nature Biotechnology.

[2] John Quackenbush,et al. Genesis: cluster analysis of microarray data , 2002, Bioinform..

[3] W. Weckwerth. Metabolomics in systems biology. , 2003, Annual review of plant biology.

[4] Manor Askenazi,et al. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains , 2003, Nature Biotechnology.

[5] Ross D. King,et al. Application of metabolomics to plant genotype discrimination using statistics and machine learning , 2002, ECCB.

[6] Inge Jonassen,et al. J-Express: exploring gene expression data using Java , 2001, Bioinform..

[7] D. Baldwin,et al. A comparison of gel-based, nylon filter and microarray techniques to detect differential RNA expression in plants. , 1999, Current opinion in plant biology.