A genetic map of the mouse with 4,006 simple sequence length polymorphisms

We have constructed a genetic map of the mouse genome containing 4,006 simple sequence length polymorphims (SSLPs). The map provides an average spacing of 0.35 centiMorgans (cM) between markers, corresponding to about 750 kb. Approximately 90% of the genome lies within 1.1 cM of a marker and 99% lies within 2.2 cM. The markers have an average polymorphism rate of 50% in crosses between laboratory strains. The markers are distributed in a relatively uniform fashion across the genome, although some deviations from randomness can be detected. In particular, there is a significant underrepresentation of markers on the X chromosome. This map represents the two–thirds point toward our goal of developing a mouse genetic map containing 6,000 SSLPs.

[1]  J. Weber,et al.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. , 1989, American journal of human genetics.

[2]  E. Lander,et al.  Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. , 1989, Genetics.

[3]  M W Bruford,et al.  Microsatellites and their application to population genetic studies. , 1993, Current opinion in genetics & development.

[4]  A. Monaco,et al.  Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Daly,et al.  MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. , 1987, Genomics.

[6]  E. Lander,et al.  A genetic linkage map of the mouse: current applications and future prospects. , 1993, Science.

[7]  M. Wapenaar,et al.  The X chromosome shows less genetic variation at restriction sites than the autosomes. , 1986, American journal of human genetics.

[8]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[9]  J. Love,et al.  Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. , 1990, Nucleic acids research.

[10]  L. Gordon,et al.  Poisson Approximation and the Chen-Stein Method , 1990 .

[11]  E S Lander,et al.  Systematic detection of errors in genetic linkage data. , 1992, Genomics.

[12]  N. G. Copeland,et al.  Genome maps IV 1993. Wall chart. , 1993, Science.

[13]  T. Hawkins.  M13 single-strand purification using a biotinylated probe and streptavidin coated magnetic beads. , 1992, DNA sequence : the journal of DNA sequencing and mapping.

[14]  R. Michelmore,et al.  Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[15]  E S Lander,et al.  A genetic map of the mouse suitable for typing intraspecific crosses. , 1992, Genetics.

[16]  Cécile Fizames,et al.  The 1993–94 Généthon human genetic linkage map , 1994, Nature Genetics.

[17]  M. Lyon,et al.  Genetic variants and strains of the laboratory mouse , 1989 .

[18]  G. Gyapay,et al.  A second-generation linkage map of the human genome , 1992, Nature.

[19]  G. D. Stewart,et al.  A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age. , 1992, American journal of human genetics.