Child head injury criteria investigation through numerical simulation of real world trauma

Finite element modelling has been used for decades in the study of adult head injury biomechanics and determination of injury criteria. Interest is recently growing in investigation on pediatric head injury which requires elaboration of biofidelic models that take into account child's head particularities in terms of size, geometry, and mechanical properties. In this study, a finite element model of a 3-year-old child head is proposed. The model is reconstructed from real CT scan images and mechanical properties are extracted from available data in the literature. A large number of real accidents (25 falls) are reconstructed with proposed model using different brain constitutive relationships in order to investigate their influence on model response. Mechanical output parameters (HIC, pressure, shearing stress) are calculated from these simulations. Statistical analysis was performed in order to evaluate predictive capability of the parameters. Von Mises stress appears to be clearly the most predictive parameters, allowing clear distinction between injured and non-injured cases. To the authors' knowledge, this study proposes for the first time a statistically based neurological injury criterion for a pediatric population using finite element modelling.

[1]  A. Nahum,et al.  Intracranial Pressure Dynamics During Head Impact , 1977 .

[2]  Kathleen Desantis Klinich,et al.  Estimating infant head injury criteria and impact response using crash reconstruction and finite element modeling. , 2002, Stapp car crash journal.

[3]  Rémy Willinger,et al.  Finite element analysis of impact and shaking inflicted to a child , 2007, International Journal of Legal Medicine.

[4]  John A. Davis,et al.  Scientific Foundations of Paediatrics , 1974 .

[5]  H von Holst,et al.  Serious brain injury from traffic-related causes: priorities for primary prevention. , 1997, Accident; analysis and prevention.

[6]  Rémy Willinger,et al.  Human head tolerance limits to specific injury mechanisms , 2003 .

[7]  T J Kriewall,et al.  Fetal head molding: an investigation utilizing a finite element model of the fetal parietal bone. , 1980, Journal of biomechanics.

[8]  Yuko Nakahira,et al.  A combined evaluation method and a modified maximum likelihood method for injury risk curves , 2000 .

[9]  R. Hubbard,et al.  Flexure of layered cranial bone. , 1971, Journal of biomechanics.

[10]  B. Chinn,et al.  HEAD TOLERANCE LIMITS DERIVED FROM NUMERICAL REPLICATION OF REAL WORLD ACCIDENTS , 2000 .

[11]  L. Shuck,et al.  Rheological Response of Human Brain Tissue in Shear , 1972 .

[12]  R W Prager,et al.  Fetal head moulding: finite element analysis of a fetal skull subjected to uterine pressures during the first stage of labour. , 2001, Journal of biomechanics.

[13]  J. van Dommelen,et al.  The mechanical behaviour of brain tissue: large strain response and constitutive modelling. , 2006, Biorheology.

[14]  King H. Yang,et al.  Investigation of Head Injury Mechanisms Using Neutral Density Technology and High-Speed Biplanar X-ray. , 2001, Stapp car crash journal.

[15]  R. Willinger,et al.  Shear Properties of Brain Tissue over a Frequency Range Relevant for Automotive Impact Situations: New Experimental Results. , 2004, Stapp car crash journal.

[16]  R Willinger,et al.  Shear linear behavior of brain tissue over a large frequency range. , 2005, Biorheology.

[17]  King H. Yang,et al.  Is head injury caused by linear or angular acceleration , 2003 .

[18]  D F Meaney,et al.  Defining brain mechanical properties: effects of region, direction, and species. , 2000, Stapp car crash journal.

[19]  D. J. Thomas,et al.  Biomechanics of skull fracture. , 1995, Journal of neurotrauma.

[20]  Rémy Willinger,et al.  Biofidelic child head FE model to simulate real world trauma , 2008, Comput. Methods Programs Biomed..

[21]  Jac S H M Wismans,et al.  On the potential importance of non-linear viscoelastic material modelling for numerical prediction of brain tissue response: test and application. , 2002, Stapp car crash journal.

[22]  S. Kleiven Predictors for traumatic brain injuries evaluated through accident reconstructions. , 2007, Stapp car crash journal.

[23]  Harold J. Mertz,et al.  Biomechanical basis for the CRABI and Hybrid III child dummies , 1997 .

[24]  S. Margulies,et al.  Age-dependent material properties of the porcine cerebrum: effect on pediatric inertial head injury criteria. , 1998, Journal of biomechanics.

[25]  Caroline Deck,et al.  Head injury prediction capability of the HIC, HIP, SIMon and ULP criteria. , 2008, Accident; analysis and prevention.

[26]  W. Weber,et al.  [Experimental studies of skull fractures in infants]. , 1984, Zeitschrift fur Rechtsmedizin. Journal of legal medicine.

[27]  Rémy Willinger,et al.  Limitation of scaling methods in child head finite element modelling , 2007 .

[28]  K. Chinzei,et al.  Constitutive modelling of brain tissue: experiment and theory. , 1997, Journal of biomechanics.

[29]  R. Willinger,et al.  Modal and temporal analysis of head mathematical models. , 1995, Journal of neurotrauma.

[30]  H. J. Mertz,et al.  Interpretations of the Impact Responses of a 3-Year-Old Child Dummy Relative to Child Injury Potential , 1982 .

[31]  J. Dobbing,et al.  The later development of the brain and its vulnerability , 1982, Journal of Inherited Metabolic Disease.

[32]  Brittany Coats,et al.  Material properties of human infant skull and suture at high rates. , 2006, Journal of neurotrauma.

[33]  J. Vander Sloten,et al.  P020 Bending properties of cranial bone segments of new-born children , 1998 .

[34]  Susan S. Margulies,et al.  Pediatric rotational inertial brain injury: the relative influence of brain size and mechanical properties , 1999 .

[35]  Susan S. Margulies,et al.  Characterization of Pediatric Porcine Skull Properties during Impact , 2003 .

[36]  James H. McElhaney,et al.  Handbook of human tolerance , 1976 .

[37]  R L Stalnaker,et al.  A constitutive relationship for large deformation finite element modeling of brain tissue. , 1995, Journal of biomechanical engineering.

[38]  Songbai Ji,et al.  Parametric study of head impact in the infant. , 2007, Stapp car crash journal.

[39]  M. Hrapko,et al.  Identifying the mechanical behaviour of brain tissue in both shear and compression , 2007 .

[40]  S. Margulies,et al.  Infant skull and suture properties: measurements and implications for mechanisms of pediatric brain injury. , 2000, Journal of biomechanical engineering.

[41]  T J Kriewall,et al.  The elastic modulus of fetal cranial bone: a first step towards an understanding of the biomechanics of fetal head molding. , 1980, Journal of biomechanics.