Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

Vertical integration is being used to great advantage in neurobiological research on the basis of age-related cognitive decline. Such research bridges analysis between the molecular and cellular levels and the outcome of impaired psychological functions. Current use of animals models within this paradigm has defined mild cognitive impairment in a subpopulation of outbred aged Long-Evans rats by assessment of hippocampal-dependent spatial cognition. Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways.

[1]  H. Eichenbaum,et al.  Brain Aging: Impaired Coding of Novel Environmental Cues , 1997, The Journal of Neuroscience.

[2]  M. Gallagher,et al.  Metabotropic Glutamate Receptor-Mediated Hippocampal Phosphoinositide Turnover Is Blunted in Spatial Learning-Impaired Aged Rats , 1999, The Journal of Neuroscience.

[3]  J. Herman,et al.  Printed in U.S.A. Copyright © 2002 by The Endocrine Society Decrements in Nuclear Glucocorticoid Receptor (GR) Protein Levels and DNA Binding in Aged Rat Hippocampus , 2022 .

[4]  H. Akil,et al.  The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat , 1994, Molecular and Cellular Neuroscience.

[5]  K. Baskerville,et al.  Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents , 2001, Neuroscience.

[6]  C. Barnes.  Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. , 1979, Journal of comparative and physiological psychology.

[7]  R. Burwell,et al.  Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits. , 2002, Cerebral cortex.

[8]  M. Gallagher,et al.  Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  T. Foster,et al.  Increased Susceptibility to Induction of Long-Term Depression and Long-Term Potentiation Reversal during Aging , 1996, The Journal of Neuroscience.

[10]  Jens Christian Sørensen,et al.  Memory impaired aged rats: No loss of principal hippocampal and subicular neurons , 1996, Neurobiology of Aging.

[11]  H. Lipp,et al.  Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice , 2000, EMBO reports.

[12]  M. Tuszynski,et al.  Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats , 2001, The Journal of comparative neurology.

[13]  M. Gallagher,et al.  Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[14]  P. Rapp.  Neuropsychological analysis of learning and memory in the aged nonhuman primate , 1993, Neurobiology of Aging.

[15]  John A. Cidlowski,et al.  CBP (CREB Binding Protein) Integrates NF-κB (Nuclear Factor-κB) and Glucocorticoid Receptor Physical Interactions and Antagonism , 2000 .

[16]  M. Gallagher,et al.  Visualization of muscarinic receptor‐mediated phosphoinositide turnover in the hippocampus of young and aged, learning‐impaired Long Evans rats , 2001, Hippocampus.

[17]  H. Eichenbaum,et al.  Brain Aging: Changes in the Nature of Information Coding by the Hippocampus , 1997, The Journal of Neuroscience.

[18]  S. Gauthier,et al.  Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  M. Gallagher,et al.  Hippocampal muscarinic receptor function in spatial learning-impaired aged rats , 1995, Neurobiology of Aging.

[20]  Edward L. Schneider,et al.  Handbook of the Biology of Aging , 1990 .

[21]  B. McEwen.  Stress and the Aging Hippocampus , 1999, Frontiers in Neuroendocrinology.

[22]  Lee W. Campbell,et al.  Aging Changes in Voltage-Gated Calcium Currents in Hippocampal CA1 Neurons , 1996, The Journal of Neuroscience.

[23]  M. Gallagher,et al.  Hypothalamic–pituitary–adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long–Evans rats , 2001, The European journal of neuroscience.

[24]  B L McNaughton,et al.  An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. , 1985, Behavioral neuroscience.

[25]  W E Skaggs,et al.  The Effect of Aging on Experience-Dependent Plasticity of Hippocampal Place Cells , 1997, The Journal of Neuroscience.

[26]  G. Rose,et al.  Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats , 1993, Hippocampus.

[27]  D. R. Smith,et al.  Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus , 2001, Neurobiology of Aging.

[28]  F. Tronche,et al.  Molecular Genetic Analysis of Glucocorticoid Signaling Using the Cre/loxP System , 2000, Biological chemistry.

[29]  A. M. Dam,et al.  THE DENSITY OF NEURONS IN THE HUMAN HIPPOCAMPUS , 1979 .

[30]  C. Barnes,et al.  Age-related decrease in cholinergic synaptic transmission in three hippocampal subfields , 1996, Neurobiology of Aging.

[31]  T. A. Pitler,et al.  Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. , 1984, Science.

[32]  B. McNaughton,et al.  Multistability of cognitive maps in the hippocampus of old rats , 1997, Nature.

[33]  J. Troncoso,et al.  Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease , 1994, The Lancet.

[34]  C. Culmsee,et al.  Roles of Nuclear Factor κB in Neuronal Survival and Plasticity , 2000 .