Impact of nanotechnology in cancer: emphasis on nanochemoprevention

Since its advent in the field of cancer, nanotechnology has provided researchers with expertise to explore new avenues for diagnosis, prevention, and treatment of the disease. Utilization of nanotechnology has enabled the development of devices in nanometer (nm) sizes which could be designed to encapsulate useful agents that have shown excellent results but otherwise are generally toxic due to the doses intended for extended use. In addition, examples are also available where these devices are easily conjugated with several purposeful moieties for better localization and targeted delivery. We introduced a novel concept in which nanotechnology was utilized for enhancing the outcome of chemoprevention. This idea, which we termed as “nanochemoprevention,” was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the up and coming applications of nanotechnology for cancer detection, imaging, treatment, and prevention. Further, we detail the current and future utilization of nanochemoprevention for prevention and treatment of cancer.

[1]  Shaker A Mousa,et al.  Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers , 2009, International journal of nanomedicine.

[2]  Narendra Kumar Jain,et al.  Dendrimers in oncology: an expanding horizon. , 2009, Chemical reviews.

[3]  Abhishek Sahu,et al.  Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. , 2008, Acta biomaterialia.

[4]  R. Blumenthal,et al.  Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. , 2008, International journal of oncology.

[5]  A. Anagnostopoulos,et al.  The use of liposomal daunorubicin (DaunoXome) in acute myeloid leukemia , 2005, Leukemia & lymphoma.

[6]  Raj Kumar,et al.  Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). , 2003, International journal of oncology.

[7]  S. Sahoo,et al.  Nanotech approaches to drug delivery and imaging. , 2003, Drug discovery today.

[8]  M. Gilbert,et al.  An Open Label Trial of Sustained-release Cytarabine (DepoCyt™) for the Intrathecal Treatment of Solid Tumor Neoplastic Meningitis , 2004, Journal of Neuro-Oncology.

[9]  V. Torchilin Antibody-modified liposomes for cancer chemotherapy. , 2008, Expert Opinion on Drug Delivery.

[10]  W. D. de Jong,et al.  Drug delivery and nanoparticles: Applications and hazards , 2008, International journal of nanomedicine.

[11]  F. Marshall,et al.  In vivo molecular and cellular imaging with quantum dots. , 2005, Current opinion in biotechnology.

[12]  Maurizio Prato,et al.  Double functionalization of carbon nanotubes for multimodal drug delivery. , 2006, Chemical communications.

[13]  Hassan S. Bazzi,et al.  Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots , 2005, Journal of Molecular Medicine.

[14]  Michel Vert,et al.  Biodistribution of Long-Circulating PEG-Grafted Nanocapsules in Mice: Effects of PEG Chain Length and Density , 2001, Pharmaceutical Research.

[15]  J. Blay,et al.  Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. , 2001, European journal of cancer.

[16]  Amane Shiohara,et al.  On the Cyto‐Toxicity Caused by Quantum Dots , 2004, Microbiology and immunology.

[17]  T. Okano,et al.  Development of the polymer micelle carrier system for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[18]  B. Longley,et al.  Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  Vladimir P. Torchilin,et al.  Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Yong Zhang,et al.  Nanoparticles in photodynamic therapy: an emerging paradigm. , 2008, Advanced drug delivery reviews.

[21]  N. Banik,et al.  Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth , 2008, Journal of cellular and molecular medicine.

[22]  A. Boddy,et al.  A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin , 2001, British Journal of Cancer.

[23]  A. Barras,et al.  Formulation and characterization of polyphenol-loaded lipid nanocapsules. , 2009, International journal of pharmaceutics.

[24]  Paras N Prasad,et al.  Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. , 2005, Journal of the American Chemical Society.

[25]  C. Jérôme,et al.  Nanoparticles in biomedical imaging , 2013 .

[26]  R. Müller,et al.  Resveratrol nanosuspensions for dermal application--production, characterization, and physical stability. , 2009, Die Pharmazie.

[27]  Sung Ju Cho,et al.  Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells , 2007, Journal of nanobiotechnology.

[28]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. Chao,et al.  Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: a report of two cases and review of the literature. , 2010, Tumori.

[30]  S. Nie,et al.  Nanotechnology applications in cancer. , 2007, Annual review of biomedical engineering.

[31]  C. Mohanty,et al.  Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy. , 2010, Nanomedicine.

[32]  L. Zhang,et al.  Nanoparticles in Medicine: Therapeutic Applications and Developments , 2008, Clinical pharmacology and therapeutics.

[33]  B. Tromberg,et al.  Fluorescence imaging studies for the disposition of daunorubicin liposomes (DaunoXome) within tumor tissue. , 1996, Cancer research.

[34]  Y. Lvov,et al.  (-)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules. , 2009, Journal of colloid and interface science.

[35]  M. Ozkan,et al.  Nano-oncology: drug delivery, imaging, and sensing , 2006, Analytical and bioanalytical chemistry.

[36]  P. Alivisatos The use of nanocrystals in biological detection , 2004, Nature Biotechnology.

[37]  H. Tønnesen Solubility, chemical and photochemical stability of curcumin in surfactant solutions. Studies of curcumin and curcuminoids, XXVIII. , 2002, Die Pharmazie.

[38]  S. Sahoo,et al.  Efficacy of transferrin‐conjugated paclitaxel‐loaded nanoparticles in a murine model of prostate cancer , 2004, International journal of cancer.

[39]  V. Meera,et al.  Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer. , 2009, Journal of biomedical nanotechnology.

[40]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[41]  M. Brechbiel,et al.  Dendrimer-based Macromolecular MRI Contrast Agents: Characteristics and Application , 2003, Molecular imaging.

[42]  S. Mousa,et al.  Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate. , 2009, Cancer research.

[43]  M. R. Kumar,et al.  Nanoparticles enhance per oral bioavailability of poorly available molecules: epigallocatechin gallate nanoparticles ameliorates cyclosporine induced nephrotoxicity in rats at three times lower dose than oral solution , 2008 .

[44]  Vasudha Sundram,et al.  Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth , 2010, Journal of ovarian research.

[45]  Kenneth K. Chan,et al.  Phase I and pharmacologie study of liposomal daunorubicin (DaunoXome) , 2004, Investigational New Drugs.

[46]  R. Das,et al.  Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. , 2010, Nanomedicine : nanotechnology, biology, and medicine.

[47]  Nobuhiro Nishiyama,et al.  Nanomedicine: nanocarriers shape up for long life. , 2007, Nature nanotechnology.

[48]  A. Chan,et al.  Liposomal doxorubicin-associated acute hypersensitivity despite appropriate preventive measures , 2007, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

[49]  W. Grizzle,et al.  Polyethylene Glycosylated Curcumin Conjugate Inhibits Pancreatic Cancer Cell Growth through Inactivation of Jab1 , 2009, Molecular Pharmacology.

[50]  S. Sahoo,et al.  Cancer nanotechnology: application of nanotechnology in cancer therapy. , 2010, Drug discovery today.

[51]  S. Onoue,et al.  Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. , 2010, Journal of pharmaceutical sciences.

[52]  Xu Wang,et al.  Application of Nanotechnology in Cancer Therapy and Imaging , 2008, CA: a cancer journal for clinicians.

[53]  L. Recht,et al.  A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[54]  N. Narayanan,et al.  Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice , 2009, International journal of cancer.

[55]  Lu Tie,et al.  Curcumin‐loaded poly(ε‐caprolactone) nanofibres: Diabetic wound dressing with anti‐oxidant and anti‐inflammatory properties , 2009, Clinical and experimental pharmacology & physiology.

[56]  Jong-Chul Park,et al.  Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations , 2009, Biomedical materials.

[57]  V. Labhasetwar,et al.  Biodegradable nanoparticles for cytosolic delivery of therapeutics. , 2007, Advanced drug delivery reviews.

[58]  B. Aggarwal,et al.  Curcumin: A component of the golden spice, targets multiple angiogenic pathways , 2011, Cancer biology & therapy.

[59]  J. Szebeni Complement activation-related pseudoallergy caused by amphiphilic drug carriers: the role of lipoproteins. , 2005, Current drug delivery.

[60]  Freitas Robert A.Jr CURRENT STATUS OF NANOMEDICINE AND MEDICAL NANOROBOTICS , 2005 .

[61]  C. Niemeyer Semi-synthetic nucleic acid-protein conjugates: applications in life sciences and nanobiotechnology. , 2001, Journal of biotechnology.

[62]  J. Nagy,et al.  Respiratory toxicity of multi-wall carbon nanotubes. , 2005, Toxicology and applied pharmacology.

[63]  P. Choyke,et al.  Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging. , 2007, Bioconjugate chemistry.

[64]  V. Torchilin,et al.  Biodegradable long-circulating polymeric nanospheres. , 1994, Science.

[65]  Audrey Player,et al.  Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer. , 2005, Nanomedicine : nanotechnology, biology, and medicine.

[66]  M. Blagosklonny How Cancer Could be Cured by 2015 , 2005, Cell cycle.

[67]  Robert Langer,et al.  Impact of nanotechnology on drug delivery. , 2009, ACS nano.

[68]  B. Aggarwal,et al.  Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. , 2010, Biochemical pharmacology.

[69]  Kazunori Kataoka,et al.  Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. , 2005, Bioconjugate chemistry.

[70]  Vincent Noireaux,et al.  In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles , 2002, Science.

[71]  Shimon Weiss,et al.  Advances in fluorescence imaging with quantum dot bio-probes. , 2006, Biomaterials.

[72]  G. Hardee,et al.  Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo. , 2003, Bioconjugate chemistry.

[73]  C. Nardoni,et al.  Weekly Regimen of Paclitaxel and Carboplatin as First-Line Chemotherapy in Elderly Patients with Stage IIIB-IV Non Small Cell Lung Cancer (NSCLC): Results of a Phase II Study , 2010, Journal of chemotherapy.

[74]  Shuming Nie,et al.  Engineering Luminescent Quantum Dots for In Vivo Molecular and Cellular Imaging , 2006, Annals of Biomedical Engineering.

[75]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[76]  M. Morandi,et al.  Nanoparticle‐induced platelet aggregation and vascular thrombosis , 2005, British journal of pharmacology.

[77]  Thommey P. Thomas,et al.  Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting. , 2005, Chemistry & biology.

[78]  Linda K. Molnar,et al.  Nanotechnology for cancer diagnostics: promises and challenges , 2006, Expert review of molecular diagnostics.

[79]  Xiabin Jing,et al.  Synthesis and characterization of RGD peptide grafted poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-glutamic acid) triblock copolymer. , 2006, Biomacromolecules.

[80]  Sérgio Simões,et al.  On the formulation of pH-sensitive liposomes with long circulation times. , 2004, Advanced drug delivery reviews.

[81]  M. Prato,et al.  Biomedical applications of functionalised carbon nanotubes. , 2005, Chemical communications.

[82]  Amit Kumar Srivastava,et al.  Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles. , 2011, Journal of biomedical nanotechnology.

[83]  T. Thundat,et al.  Bioassay of prostate-specific antigen (PSA) using microcantilevers , 2001, Nature Biotechnology.

[84]  Allan G. A. Coombes,et al.  Surface Modification of Poly(lactide-co-glycolide) Nanospheres by Biodegradable Poly(lactide)-Poly(ethylene glycol) Copolymers , 1994, Pharmaceutical Research.

[85]  J. Gilman,et al.  Nanotechnology , 2001 .

[86]  M. Ferrari Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[87]  Scott E McNeil,et al.  Nanoparticle therapeutics: a personal perspective. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[88]  I. Larson,et al.  Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[89]  Yonghou Jiang,et al.  SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. , 2005, AIDS research and human retroviruses.

[90]  Yi Yan Yang,et al.  Synergistic anticancer effects achieved by co-delivery of TRAIL and paclitaxel using cationic polymeric micelles. , 2011, Macromolecular bioscience.

[91]  S. Gambhir,et al.  Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics , 2005, Science.

[92]  B. Aggarwal,et al.  Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals , 2010, Cancer and Metastasis Reviews.

[93]  J. Shamash,et al.  Phase II trial of liposomal daunorubicin in malignant pleural mesothelioma. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

[94]  Donald A Tomalia,et al.  Dendrimers in biomedical applications--reflections on the field. , 2005, Advanced drug delivery reviews.

[95]  John Samuel,et al.  Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery. , 2002, Advanced drug delivery reviews.

[96]  Thomas H. Parker,et al.  What is π , 1991 .

[97]  Si-Shen Feng,et al.  Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. , 2004, Current medicinal chemistry.

[98]  W. Tiyaboonchai,et al.  Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. , 2007, International journal of pharmaceutics.

[99]  Swarnlata Saraf,et al.  Nanocarriers: promising vehicle for bioactive drugs. , 2006, Biological & pharmaceutical bulletin.

[100]  J. Shao,et al.  Enhanced growth inhibition effect of resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levels. , 2009, Colloids and surfaces. B, Biointerfaces.

[101]  S. Nie,et al.  Molecular profiling of single cancer cells and clinical tissue specimens with semiconductor quantum dots , 2006, International journal of nanomedicine.

[102]  Murali M. Yallapu,et al.  Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. , 2010, Journal of colloid and interface science.

[103]  Theresa M Allen,et al.  Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer. , 2004, Biochimica et biophysica acta.

[104]  R. Smalley,et al.  Structure-Assigned Optical Spectra of Single-Walled Carbon Nanotubes , 2002, Science.

[105]  I. Rubinstein,et al.  Nanomicellar paclitaxel increases cytotoxicity of multidrug resistant breast cancer cells. , 2009, Cancer letters.

[106]  N Thatcher,et al.  Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer , 2006, British Journal of Cancer.

[107]  D. P. O'Neal,et al.  Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. , 2009, ACS nano.

[108]  E. Tsuchida,et al.  Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol). , 2009, Journal of biomedical nanotechnology.

[109]  Shuming Nie,et al.  Quantum dots for in vivo molecular and cellular imaging. , 2007, Methods in molecular biology.

[110]  Henk-Jan Guchelaar,et al.  Liposomal drug formulations in cancer therapy: 15 years along the road. , 2012, Drug discovery today.

[111]  S. Thakur,et al.  Emerging Implications of Nanotechnology on Cancer Diagnostics and Therapeutics , 2012 .

[112]  Xing-Jie Liang,et al.  Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger , 2008, Molecular Pharmacology.

[113]  T. Webb,et al.  Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[114]  M. Yeh,et al.  The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles. , 2011, Biomaterials.

[115]  Lei Yu,et al.  Synthesis, characterization, and biological evaluation of poly(L-γ-glutamyl-glutamine)- paclitaxel nanoconjugate , 2010, International journal of nanomedicine.

[116]  Robert A Freitas,et al.  What is nanomedicine? , 2005, Disease-a-month : DM.

[117]  K. Kataoka,et al.  NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel , 2005, British Journal of Cancer.

[118]  J. Vishwanatha,et al.  Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. , 2009, Anticancer research.

[119]  M. R. Kumar,et al.  Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[120]  D. Pode,et al.  Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer , 2000, Anti-cancer drugs.

[121]  Weizhen He,et al.  [Study on the preparation of resveratrol chitosan nanoparticles with free amino groups on the surface]. , 2006, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[122]  J. Pezzuto,et al.  Cancer Chemopreventive Activity of Resveratrol , 2002, Drugs under experimental and clinical research.

[123]  M. Coelho,et al.  Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention. , 2011, Nanomedicine.

[124]  Masato Yasuhara,et al.  Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine: surface modification regulates biological function, including cytotoxicity , 2007, Journal of Artificial Organs.

[125]  S. Simões,et al.  Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[126]  Gorka Orive,et al.  Techniques: new approaches to the delivery of biopharmaceuticals. , 2004, Trends in pharmacological sciences.

[127]  Vincristine liposomal--INEX: lipid-encapsulated vincristine, onco TCS, transmembrane carrier system--vincristine, vincacine, vincristine sulfate liposomes for injection, VSLI. , 2004, Drugs in R&D.

[128]  R. Müller,et al.  The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. , 1995, Advanced drug delivery reviews.

[129]  G. Feldmann,et al.  Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy , 2007, Journal of nanobiotechnology.

[130]  Lois Magner,et al.  Diagnostics and Therapeutics , 2005 .

[131]  Y. Zu,et al.  [Preparation, activity and targeting ability evaluation in vitro on folate mediated epigallocatechin-3-gallate albumin nanoparticles]. , 2009, Yao xue xue bao = Acta pharmaceutica Sinica.

[132]  Caroline Seydel,et al.  Quantum Dots Get Wet , 2003, Science.

[133]  J. Kristl,et al.  The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. , 2010, International journal of pharmaceutics.

[134]  Leone Spiccia,et al.  Nanomaterials: Applications in Cancer Imaging and Therapy , 2011, Advanced materials.

[135]  D. Ding,et al.  Resveratrol-loaded polymeric micelles protect cells from Abeta-induced oxidative stress. , 2009, International journal of pharmaceutics.