Context: Lower back pain (LBP) is one of the most common musculoskeletal symptoms among health care providers. Aims: This study aimed to determine the prevalence and the effects of LBP among medical practitioners in King Abdulaziz Medical City (KAMC) in Riyadh. Subjects and Methods: This cross-sectional study was conducted in KAMC in Riyadh, Saudi Arabia (over six months period of time). The study included a group of physicians, surgeons, nurses, paramedics, and other medical practitioners of different nationalities. A survey was sent to 174 conveniently selected participants to be filled and completed. Both descriptive and inferential tests were reported. Chi-square, t-test, and ANOVA tests were used when appropriate. A P < 0.05 was identified as statistically significant for all the tests. Results: The lifetime prevalence of back pain among all the participants was found to be 83.9% (146). The mean age of participants was 33.5 ± 9.6. Male participants were 121 (71.2%). The sample included 114 (65.9%) medical doctors. It has been found that 135 (92.5%) of the study participants had a minimal disability, 10 (6.8%) had moderate disability, and only 1 (0.7%) had severe disability. Conclusions: Work-related complaints are a major issue facing employees and employers worldwide. It varies according to the type of work. LBP is a common problem that many workers suffer from. It is recommended to conduct further researches to study the burden of this problem in different aspects, such as psychological and social.