Inactive Tlk associating with Tak1 increases p38 MAPK activity to prolong the G2 phase

[1]  J. Olsen,et al.  Molecular basis of Tousled-Like Kinase 2 activation , 2018, Nature Communications.

[2]  Z. Mao,et al.  p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1 , 2018, The Journal of cell biology.

[3]  Caty Casas.  GRP78 at the Centre of the Stage in Cancer and Neuroprotection , 2017, Front. Neurosci..

[4]  G. Liaw.  Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation , 2016, Scientific Reports.

[5]  R. Schiff,et al.  Amplification of TLK2 Induces Genomic Instability via Impairing the G2–M Checkpoint , 2016, Molecular Cancer Research.

[6]  R. Medema,et al.  Tousled‐like kinase 2 regulates recovery from a DNA damage‐induced G2 arrest , 2016, EMBO reports.

[7]  R. Zhou,et al.  Tousled-like kinase mediated a new type of cell death pathway in Drosophila , 2015, Cell Death and Differentiation.

[8]  G. Liaw,et al.  Modulation of cell morphogenesis by tousled‐like kinase in the Drosophila follicle cell , 2015, Developmental dynamics : an official publication of the American Association of Anatomists.

[9]  Benjamin P. C. Chen,et al.  The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry1 , 2015, Neoplasia.

[10]  Xiaojun Tan,et al.  A Kinase-Independent Role for EGF Receptor in Autophagy Initiation , 2015, Cell.

[11]  S. Kaul,et al.  Identification and Functional Characterization of Nuclear Mortalin in Human Carcinogenesis* , 2014, The Journal of Biological Chemistry.

[12]  Susan S. Taylor,et al.  Kinases and Pseudokinases: Lessons from RAF , 2014, Molecular and Cellular Biology.

[13]  S. Davey,et al.  Tousled-Like Kinase-Dependent Phosphorylation of Rad9 Plays a Role in Cell Cycle Progression and G2/M Checkpoint Exit , 2013, PloS one.

[14]  Dmytro Starenki,et al.  A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase , 2013, Molecular and Cellular Biology.

[15]  J. Arthur,et al.  Mitogen-activated protein kinases in innate immunity , 2013, Nature Reviews Immunology.

[16]  Chuay-Yeng Koo,et al.  The dual function of KSR1: a pseudokinase and beyond. , 2013, Biochemical Society transactions.

[17]  J. Vijg,et al.  Genome instability and aging. , 2013, Annual review of physiology.

[18]  J. Massagué.  TGFβ signalling in context , 2012, Nature Reviews Molecular Cell Biology.

[19]  S. Razin,et al.  Dual effect of heat shock on DNA replication and genome integrity , 2012, Molecular biology of the cell.

[20]  A. Benedetti.  The Tousled-Like Kinases as Guardians of Genome Integrity , 2012 .

[21]  F. Oesch,et al.  Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts , 2012, Cell Communication and Signaling.

[22]  M. Kelliher,et al.  A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF-κB and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage , 2011, Molecular and Cellular Biology.

[23]  D. Krappmann,et al.  Signals from the Nucleus: Activation of NF-κB by Cytosolic ATM in the DNA Damage Response , 2011, Science Signaling.

[24]  Xiurong Wu,et al.  Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi , 2010, Proceedings of the National Academy of Sciences.

[25]  N. Tapon,et al.  Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. , 2010, Molecular cell.

[26]  P. Kogerman,et al.  Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway* , 2010, The Journal of Biological Chemistry.

[27]  P. Hinds,et al.  Distinct subcellular distribution of cyclin dependent kinase 6 , 2009, Cell cycle.

[28]  A. De Benedetti,et al.  Tousled homolog, TLK1, binds and phosphorylates Rad9; TLK1 acts as a molecular chaperone in DNA repair. , 2009, DNA repair.

[29]  Christopher S. Chen,et al.  Mechanotransduction in development: a growing role for contractility , 2009, Nature Reviews Molecular Cell Biology.

[30]  G. Liaw,et al.  mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila , 2009, Journal of Biomedical Science.

[31]  T. Umeyama,et al.  The Chromosomal Passenger Complex and a Mitotic Kinesin Interact with the Tousled-Like Kinase in Trypanosomes to Regulate Mitosis and Cytokinesis , 2008, PloS one.

[32]  Ching C. Wang,et al.  Tousled-like kinase in a microbial eukaryote regulates spindle assembly and S-phase progression by interacting with Aurora kinase and chromatin assembly factors , 2007, Journal of Cell Science.

[33]  G. Brooks,et al.  Regulation of cell cycle and stress responses to hydrostatic pressure in fission yeast. , 2007, Molecular biology of the cell.

[34]  A. Cuenda,et al.  p38 MAP-kinases pathway regulation, function and role in human diseases. , 2007, Biochimica et biophysica acta.

[35]  E. Garí,et al.  Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. , 2007, Molecular cell.

[36]  A. De Benedetti,et al.  Bmc Molecular Biology Tlk1b Promotes Repair of Uv-damaged Dna through Chromatin Remodeling by Asf1 , 2022 .

[37]  Susan E. Mango,et al.  The C. elegans Tousled-like Kinase Contributes to Chromosome Segregation as a Substrate and Regulator of the Aurora B Kinase , 2005, Current Biology.

[38]  Y. Ip,et al.  A Drosophila p38 orthologue is required for environmental stress responses , 2004, EMBO reports.

[39]  R. Gaynor,et al.  Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling , 2003, The EMBO journal.

[40]  S. Mango,et al.  The C. elegans Tousled-like Kinase (TLK-1) Has an Essential Role in Transcription , 2003, Current Biology.

[41]  P. Lasko,et al.  Fat Facets Interacts with Vasa in the Drosophila Pole Plasm and Protects It from Degradation , 2003, Current Biology.

[42]  F. Karch,et al.  Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. , 2003, Genes & development.

[43]  H. Ino.  Antigen Retrieval by Heating En Bloc for Pre-fixed Frozen Material , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[44]  J. Bartek,et al.  Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint , 2003, The EMBO journal.

[45]  A. Mikhailov,et al.  Cell Cycle: Stressed Out of Mitosis , 2002, Current Biology.

[46]  E. Appella,et al.  Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase , 2001, Nature.

[47]  J. Mihály,et al.  The role of the Drosophila TAK homologue dTAK during development , 2001, Mechanisms of Development.

[48]  N. Baker,et al.  The EGF Receptor Defines Domains of Cell Cycle Progression and Survival to Regulate Cell Number in the Developing Drosophila Eye , 2001, Cell.

[49]  Z. Dong,et al.  ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation* , 2000, The Journal of Biological Chemistry.

[50]  B. Sanson,et al.  A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. , 1999, Genetics.

[51]  K. Tanaka,et al.  Mammalian homologues of the plant Tousled gene code for cell‐cycle‐regulated kinases with maximal activities linked to ongoing DNA replication , 1999, EMBO Journal.

[52]  K. Irie,et al.  p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis , 1999, Molecular and Cellular Biology.

[53]  M. Freeman,et al.  Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye , 1996, Cell.

[54]  Ruth J. Muschel,et al.  Cell Cycle-dependent Regulation of the Cyclin B1 Promoter (*) , 1995, The Journal of Biological Chemistry.

[55]  N. Sivasubramanian,et al.  Interaction Site of GTP Binding Gh (Transglutaminase II) with Phospholipase C (*) , 1995, The Journal of Biological Chemistry.

[56]  Jiahuai Han,et al.  Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*) , 1995, The Journal of Biological Chemistry.

[57]  K. Feldmann,et al.  The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development , 1993, Cell.

[58]  V. Hartenstein,et al.  Sensillum development in the absence of cell division: the sensillum phenotype of the Drosophila mutant string. , 1990, Developmental biology.

[59]  P. Young,et al.  Heat shock mRNA accumulation during recovery from cold shock in Drosophila melanogaster , 1990 .

[60]  J. C. Li,et al.  Development in DROSOPHILA MELANOGASTER. , 1927, Genetics.