Bioreactors for Mammalian Cells: General Overview

For the development and manufacturing of biotechnological medicines, the in vitro cultivation of animal cells has now become an accepted technology. In fact, about 50% of all commercial biotechnological products used for in vivo diagnostic and therapeutic purposes today are made using procedures based on animal cells. In addition to products from cells that are glycoproteins (drug products, e.g., cytokines, growth hormones, hematopoietic growth factors and antibodies, and viral vaccines, see Chaps. 1 and 2), cells as products for regenerative medicine, namely cellular therapies and tissue engineering, have been successfully investigated in clinical trials and introduced on the market.

[1]  Regine Eibl-Schindler,et al.  Kostenreduktion bei der Säugerzellkultivierung durch Einwegbioreaktoren , 2003 .

[2]  P. Weathers,et al.  Secondary metabolism of hairy root cultures in bioreactors , 2007, In Vitro Cellular & Developmental Biology - Plant.

[3]  Athanassios Sambanis,et al.  Cell Culture Bioreactors , 2001 .

[4]  E. L. Stadler.  DUAL PURPOSE FERMENTOR AND BIOREACTOR? A CAPITAL QUANDARY! , 1998 .

[5]  John G. Aunins,et al.  Viral Vaccine Production in Cell Culture , 2003 .

[6]  Rui L Reis,et al.  Tissue engineering: key elements and some trends. , 2004, Macromolecular bioscience.

[7]  K. Schügerl.  Neue Bioreaktoren für aerobe Prozesse , 1980 .

[8]  L D Solem,et al.  A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. , 1997, The Journal of burn care & rehabilitation.

[9]  A. Kadouri,et al.  CONTINUOUS PRODUCTION OF MONOCLONAL ANTIBODIES IN CELLIGEN PACKED BED REACTOR USING FIBRA-CEL CARRIER , 1992 .

[10]  B. Kunz,et al.  Klassifikationssystem für Fermentationsprozesse , 2005 .

[11]  A. Petrossian,et al.  Large-scale production of monoclonal antibodies in defined serum-free media in airlift bioreactors. , 1990, BioTechniques.

[12]  Alexander Augst,et al.  Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. , 2006, Biomaterials.

[13]  W. Minuth,et al.  Zukunftstechnologie Tissue Engineering: Von der Zellbiologie zum künstlichen Gewebe , 2005 .

[14]  C. A. M. van der Velden-de Groot,et al.  Microcarrier technology, present status and perspective , 2004, Cytotechnology.

[15]  A. Mantalaris,et al.  Haematopoietic Culture Systems , 2005 .

[16]  T. Alan Hatton,et al.  Cell death from bursting bubbles: Role of cell attachment to rising bubbles in sparged reactors , 1999 .

[17]  F W Falkenberg,et al.  Production of monoclonal antibodies in the miniPERM bioreactor: comparison with other hybridoma culture methods. , 1998, Research in immunology.

[18]  Philippe Girard,et al.  TubeSpin satellites: a fast track approach for process development with animal cells using shaking technology , 2004 .

[19]  M. Carrondo,et al.  Animal Cell Technology , 1997, Springer Netherlands.

[20]  Björn Lundgren,et al.  Microcarriers in Cell Culture Production , 2008 .

[21]  D K Glencross,et al.  Manufacture of pure monoclonal antibodies by heterogeneous culture without downstream purification. , 2001, BioTechniques.

[22]  M. J. Guardia,et al.  Mammalian Cell Bioreactors , 2002 .

[23]  Hong Jiang,et al.  Creation of Engineered Cardiac Tissue In Vitro From Mouse Embryonic Stem Cells , 2006, Circulation.

[24]  Victoria Boyd,et al.  Dialysis-based bioreactor systems for the production of monoclonal antibodies--alternatives to ascites production in mice. , 2002, Journal of immunological methods.

[25]  D. Wendt,et al.  The role of bioreactors in tissue engineering. , 2004, Trends in biotechnology.

[26]  D Weuster-Botz,et al.  Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). , 2005, Biotechnology and bioengineering.

[27]  Bryan Griffiths,et al.  Animal Cell Products, Overview , 2003 .

[28]  Ruian Xu,et al.  The bioreactor: a powerful tool for large-scale culture of animal cells. , 2005, Current pharmaceutical biotechnology.

[29]  Anthony Ratcliffe,et al.  Bioreactors and Bioprocessing for Tissue Engineering , 2002, Annals of the New York Academy of Sciences.

[30]  J. Merchuk,et al.  Bioreactors, Air-lift Reactors , 2002 .

[31]  Jacqueline Senker,et al.  Research activities and future development of human tissue engineering in Europe and the US , 2003 .

[32]  J E Dowd,et al.  Predictive control of hollow-fiber bioreactors for the production of monoclonal antibodies. , 1999, Biotechnology and bioengineering.

[33]  P. E. McHugh,et al.  Bioreactors for Cardiovascular Cell and Tissue Growth: A Review , 2003, Annals of Biomedical Engineering.

[34]  Wei-Shou Hu,et al.  Cell culture technology for pharmaceutical and cell-based therapies , 2005 .

[35]  L. Nielsen,et al.  Bioreactors for hematopoietic cell culture. , 1999, Annual review of biomedical engineering.

[36]  G. Kretzmer,et al.  Industrial processes with animal cells , 2002, Applied Microbiology and Biotechnology.

[37]  Richard Moore,et al.  Human tissue-engineered products. , 2003, Medical device technology.

[38]  R. Spier,et al.  Animal Cell Biotechnology , 1988, 1988.

[39]  Gargi Maheshwari,et al.  Quantitation of interaction of lipids with polymer surfaces in cell culture. , 2007, Biotechnology and bioengineering.

[40]  Cláudia Lobato da Silva,et al.  Hematopoietic stem cells: from the bone to the bioreactor. , 2003, Trends in biotechnology.

[41]  P. Shabram,et al.  Scalability of a Disposable Bioreactor from 25 L-500 L Run in Perfusion Mode with a CHO-Based Cell Line: A Tech Review , 2004 .

[42]  Glyn Stacey,et al.  Culture of Human Stem Cells , 2007 .

[43]  F. Wurm.  Production of recombinant protein therapeutics in cultivated mammalian cells , 2004, Nature Biotechnology.

[44]  K. Mosbach,et al.  Growth of Anchorage–Dependent Cells on Macroporous Microcarriers , 1986, Bio/Technology.

[45]  John McArdle.  Report of the workshop on monoclonal antibodies. , 2004, Alternatives to laboratory animals : ATLA.

[46]  J. B. Griffiths,et al.  Mammalian Cell Culture Reactors, Scale‐Up , 2010 .

[47]  Sabine Geisse,et al.  Optimisation of protein expression and establishment of the Wave Bioreactor for Baculovirus/insect cell culture , 2004, Cytotechnology.

[48]  J. M. Chong,et al.  Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology. , 1999, Journal of immunological methods.

[49]  Ya-Jie Tang,et al.  Perfusion Culture of Hybridoma Cells for Hyperproduction of IgG2a Monoclonal Antibody in a Wave Bioreactor‐Perfusion Culture System , 2007, Biotechnology progress.

[50]  Wei-Shou Hu,et al.  Culture systems for pluripotent stem cells. , 2005, Journal of bioscience and bioengineering.

[51]  A. Kadouri,et al.  Use of a stationary bed reactor and serum-free medium for the production of recombinant proteins in insect cells. , 1991, Enzyme and microbial technology.

[52]  Christoph Giese,et al.  An Overview on Bioreactor Design, Prototyping and Process Control for Reproducible Three‐Dimensional Tissue Culture , 2006 .

[53]  Y. Chisti,et al.  Animal-cell damage in sparged bioreactors. , 2000, Trends in biotechnology.

[54]  Hammond,et al.  Characterization of bimodal cell death of insect cells in a rotating-wall vessel and shaker flask , 1999, Biotechnology and Bioengineering.

[55]  B. Mattiasson,et al.  Physiology of immobilized cells. , 1990 .

[56]  Diego Mantovani,et al.  Bioreactors for tissue engineering: focus on mechanical constraints. A comparative review. , 2006, Tissue engineering.

[57]  Xi Chen,et al.  Bioreactor Expansion of Human Adult Bone Marrow‐Derived Mesenchymal Stem Cells , 2006, Stem cells.

[58]  A. Bader,et al.  Bioreactor developments for tissue engineering applications by the example of the bioartificial liver. , 2002, Advances in biochemical engineering/biotechnology.

[59]  F Meuwly,et al.  Oxygen supply for CHO cells immobilized on a packed‐bed of Fibra‐Cel® disks , 2006, Biotechnology and bioengineering.

[60]  R. Ian Freshney,et al.  Culture of cells for tissue engineering , 1994 .

[61]  G. Subramanian,et al.  Bioseparation and Bioprocessing , 1998 .

[62]  Zhanfeng Cui,et al.  Fabrication and detection of tissue‐engineered bones with bio‐derived scaffolds in a rotating bioreactor , 2006, Biotechnology and applied biochemistry.

[63]  C. Wandrey,et al.  Production of Monoclonal Antibodies in a Pilot Scale Fluidized Bed Bioreactor , 1995 .

[64]  Kyriacos A Athanasiou,et al.  Articular cartilage bioreactors and bioprocesses. , 2003, Tissue engineering.

[65]  Junzo Tanaka,et al.  Cartilaginous tissue formation from bone marrow cells using rotating wall vessel (RWV) bioreactor. , 2006, Biotechnology and bioengineering.

[66]  Gary Walsh,et al.  Biopharmaceuticals: Biochemistry and Biotechnology , 1998 .

[67]  Sadettin S. Ozturk.  Cell Culture Technology—An Overview , 2005 .

[68]  R. Dean,et al.  Large‐Scale Culture of Hybridoma and Mammalian Cells in Fluidized Bed Bioreactors , 1987, Annals of the New York Academy of Sciences.

[69]  J. Gerlach,et al.  Development of a Hybrid Liver Support System: A Review , 1996, The International journal of artificial organs.

[70]  Vijay P. Singh,et al.  Disposable bioreactor for cell culture using wave-induced agitation , 1999, Cytotechnology.

[71]  Michael C. Flickinger,et al.  Encyclopedia of bioprocess technology : fermentation, biocatalysis, and bioseparation , 1999 .

[72]  T. Scheper,et al.  Cultivation of MC3T3-E1 cells on a newly developed material (Sponceram) using a rotating bed system bioreactor. , 2007, Journal of biomedical materials research. Part A.

[73]  A. Nienow.  Reactor Engineering in Large Scale Animal Cell Culture , 2006, Cytotechnology.

[74]  G. Lee,et al.  Justification of continuous packed-bed reactor for retroviral vector production from amphotropic ΨCRIP murine producer cell , 2000, Cytotechnology.

[75]  Rührkesselreaktoren im mL‐Maßstab: Kultivierung von Escherichia coli , 2004 .

[76]  H. Henzler.  Influence of Stress on Cell Growth and Product Formation , 2010 .

[77]  D K Robinson,et al.  Industrial choices for protein production by large-scale cell culture. , 2001, Current opinion in biotechnology.

[78]  The scale‐up from 0.1 to 100 liter of a unit process system based on 3‐mm‐diameter glass spheres for the production of four strains of FMDV from BHK monolayer cells , 1981 .

[79]  D. Lütkemeyer,et al.  The Super-Spinner: A low cost animal cell culture bioreactor for the CO2 incubator , 2004, Cytotechnology.

[80]  P. Czermak,et al.  Hydrodynamic Stimulation and Long Term Cultivation of Nucleus Pulposus Cells: A New Bioreactor System to Induce Extracellular Matrix Synthesis by Nucleus Pulposus Cells Dependent on Intermittent Hydrostatic Pressure , 2004, The International journal of artificial organs.

[81]  B. Brockway,et al.  Circadian respiratory rate rhythms in freely moving small laboratory animals using radio-telemetry. , 1999 .

[82]  J. Birch,et al.  Reactor design for large scale suspension animal cell culture , 1999, Cytotechnology.

[83]  Catherine Verfaillie,et al.  Advances in Adult Stem Cell Culture , 2005 .

[84]  U Reichl,et al.  Establishment of a mink enteritis vaccine production process in stirred-tank reactor and Wave Bioreactor microcarrier culture in 1-10 L scale. , 2007, Vaccine.

[85]  G. Walsh.  Current Status of Biopharmaceuticals: Approved Products and Trends in Approvals , 2008 .

[86]  J E Mayer,et al.  New pulsatile bioreactor for in vitro formation of tissue engineered heart valves. , 2000, Tissue engineering.

[87]  Joseph P Vacanti,et al.  Hepatic tissue engineering. , 2004, Transplant immunology.

[88]  J E Prenosil,et al.  Automated production of cultured epidermal autografts and sub-confluent epidermal autografts in a computer controlled bioreactor. , 1998, Biotechnology and bioengineering.

[89]  F. Wurm.  Manufacture of Recombinant Biopharmaceutical Proteins by Cultivated Mammalian Cells in Bioreactors , 2008 .

[90]  U Marx.  Membrane-based cell culture technologies: a scientifically and economically satisfactory alternative to malignant ascites production for monoclonal antibodies. , 1998, Research in immunology.

[91]  F. Wurm,et al.  Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems , 2007, Biotechnology Letters.

[92]  Raymond E. Spier.,et al.  Encyclopedia of cell technology , 2000 .

[93]  Richard D. Alexander,et al.  A Comparative Review , 1968 .

[94]  Bruce D. Bowen,et al.  Two-dimensional analysis of protein transport in the extracapillary space of hollow-fibre bioreactors , 1996 .

[95]  M. Butler,et al.  Erythropoietin production from CHO cells grown by continuous culture in a fluidized-bed bioreactor. , 2002, Biotechnology and bioengineering.

[96]  R. Goffe,et al.  Media Additives for High Performance Cell Culture in Hollow Fiber Bioreactors , 1995 .

[97]  Hazel Aranha,et al.  A novel aseptic connection device: Considerations for use in aseptic processing of pharmaceuticals , 2003 .

[98]  C. Legallais,et al.  Design of a fluidized bed bioartificial liver. , 2000, Artificial organs.

[99]  J. Zhong,et al.  Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures. , 2001, Advances in biochemical engineering/biotechnology.

[100]  P. Kieran,et al.  Effects of hydrodynamic and interfacial forces on plant cell suspension systems. , 2000, Advances in biochemical engineering/biotechnology.

[101]  Ivan Martin,et al.  Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering. , 2002, Journal of biomechanical engineering.

[102]  R. Kotin,et al.  Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales. , 2007, Journal of virological methods.

[103]  A. Tairi,et al.  Large scale transient 5-HT3 receptor production with the Semliki Forest Virus Expression System , 2000, Cytotechnology.