Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference

[1]  M. Burkart,et al.  Enzymology of standalone elongating ketosynthases , 2022, Chemical science.

[2]  T. Barends,et al.  Dynamics in an unusual acyl carrier protein from a ladderane lipid‐synthesizing organism , 2021, Proteins.

[3]  D. Tantillo,et al.  Potential for Ladderane (Bio)synthesis from Oligo-Cyclopropane Precursors , 2020, ACS omega.

[4]  J. Hashimoto,et al.  An unusual extender unit is incorporated into the modular polyketide synthase of scopranones biosynthesis. , 2019, Biochemistry.

[5]  N. C. van de Merbel Protein quantification by LC-MS: a decade of progress through the pages of Bioanalysis. , 2019, Bioanalysis.

[6]  J. Mccammon,et al.  Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli , 2019, Proceedings of the National Academy of Sciences.

[7]  D. Cane,et al.  pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism. , 2018, Organic & biomolecular chemistry.

[8]  S. Boxer,et al.  Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability , 2018, Proceedings of the National Academy of Sciences.

[9]  A. Sharff,et al.  Advances in automated data analysis and processing within autoPROC, combined with improved characterisation, mitigation and visualisation of the anisotropy of diffraction limits using STARANISO , 2018, Acta Crystallographica Section A Foundations and Advances.

[10]  Xu Shen,et al.  Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis , 2016, Cell Research.

[11]  D. Hua,et al.  Study of Class I and Class III Polyhydroxyalkanoate (PHA) Synthases with Substrates Containing a Modified Side Chain. , 2016, Biomacromolecules.

[12]  Vivek K. Mutalik,et al.  Investigation of Proposed Ladderane Biosynthetic Genes from Anammox Bacteria by Heterologous Expression in E. coli , 2016, PloS one.

[13]  M. Burkart,et al.  Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. , 2015, Chemistry & biology.

[14]  S. Okabe,et al.  Draft Genome Sequence of an Anaerobic Ammonium-Oxidizing Bacterium, “Candidatus Brocadia sinica” , 2015, Genome Announcements.

[15]  Sandip V Mulay,et al.  Synthetic studies on actinorhodin and γ-actinorhodin: synthesis of deoxyactinorhodin and deoxy-γ-actinorhodin/crisamicin A isomer. , 2015, Chemistry.

[16]  Paul D. Adams,et al.  FEM: feature-enhanced map , 2014, Acta crystallographica. Section D, Biological crystallography.

[17]  J. Mccammon,et al.  Trapping the dynamic acyl carrier protein in fatty acid biosynthesis , 2013, Nature.

[18]  Gavin J. Williams,et al.  Promiscuity of a modular polyketide synthase towards natural and non-natural extender units. , 2013, Organic & biomolecular chemistry.

[19]  H. O. D. op den Camp,et al.  How to make a living from anaerobic ammonium oxidation. , 2013, FEMS microbiology reviews.

[20]  P. Ramachandran,et al.  Total regio- and diastereocontrol in the aldol reactions of dienolborinates. , 2013, Organic letters.

[21]  R. Brenk,et al.  Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa. , 2013, Journal of molecular biology.

[22]  Stefan Schouten,et al.  Occurrence and distribution of ladderane oxidation products in different oceanic regimes , 2012 .

[23]  F. Garofolo,et al.  Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges. , 2012, Bioanalysis.

[24]  N. Surolia,et al.  Structural basis for the functional and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum. , 2011, Journal of structural biology.

[25]  D. Higgins,et al.  Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega , 2011, Molecular systems biology.

[26]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[27]  Randy J. Read,et al.  Acta Crystallographica Section D Biological , 2003 .

[28]  Jun Yin,et al.  Catalytic turnover-based phage selection for engineering the substrate specificity of Sfp phosphopantetheinyl transferase. , 2009, Journal of molecular biology.

[29]  T. Yokoyama,et al.  Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ). , 2009, Biochemical and biophysical research communications.

[30]  M. Strous,et al.  Carbon isotope-labelling experiments indicate that ladderane lipids of anammox bacteria are synthesized by a previously undescribed, novel pathway. , 2009, FEMS microbiology letters.

[31]  M. Strous,et al.  A comparative genomics study of genetic products potentially encoding ladderane lipid biosynthesis , 2009, Biology Direct.

[32]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[33]  Dustin H. Nouri and Dean J. Tantillo They Came From the Deep: Syntheses, Applications, and Biology of Ladderanes , 2006 .

[34]  Marc Strous,et al.  Structural identification of ladderane and other membrane lipids of planctomycetes capable of anaerobic ammonium oxidation (anammox) , 2005, The FEBS journal.

[35]  F. Winkler,et al.  The crystal structure of PfFabZ, the unique β‐hydroxyacyl‐ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum , 2005, Protein science : a publication of the Protein Society.

[36]  K. Fiebig,et al.  The Structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Pseudomonas aeruginosa* , 2004, Journal of Biological Chemistry.

[37]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[38]  Alex Bateman,et al.  The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases , 2004, BMC Bioinformatics.

[39]  Adri C. T. van Duin,et al.  Linearly concatenated cyclobutane lipids form a dense bacterial membrane , 2002, Nature.

[40]  Scott E Schaus,et al.  Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)Co(III) complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols. , 2002, Journal of the American Chemical Society.

[41]  E. Jones,et al.  The Use of Salicylaldehyde Phenylhydrazone as an Indicator for the Titration of Organometallic Reagents. , 1999, The Journal of organic chemistry.

[42]  J. Cronan,et al.  Cyclopropane ring formation in membrane lipids of bacteria , 1997, Microbiology and molecular biology reviews : MMBR.

[43]  R. Heath,et al.  Roles of the FabA and FabZ β-Hydroxyacyl-Acyl Carrier Protein Dehydratases in Escherichia coli Fatty Acid Biosynthesis* , 1996, The Journal of Biological Chemistry.

[44]  J. L. Smith,et al.  Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. , 1996, Structure.

[45]  C. Raetz,et al.  An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. , 1994, The Journal of biological chemistry.

[46]  J. Schwab,et al.  Steric course of the allylic rearrangement catalyzed by .beta.-hydroxydecanoylthioester dehydrase. Mechanistic implications , 1984 .

[47]  A. Hajra,et al.  A method for the chemical synthesis of 14C-labeled fatty acyl coenzyme A's of high specific activity. , 1980, Analytical biochemistry.

[48]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[49]  G. M. Helmkamp,et al.  Mode of inhibition of beta-hydroxydecanoyl thioester dehydrase by 3-decynoyl-N-acetylcysteamine. , 1970, The Journal of biological chemistry.

[50]  W. O'Leary THE FATTY ACIDS OF BACTERIA , 1962 .

[51]  O. Geiger,et al.  Formation of Bacterial Glycerol-Based Membrane Lipids: Pathways, Enzymes, and Reactions , 2018 .

[52]  D. Speth Metagenomics of microbial communities involved in nitrogen cycling , 2016 .

[53]  H. O. D. op den Camp,et al.  Anammox--growth physiology, cell biology, and metabolism. , 2012, Advances in microbial physiology.

[54]  C. Walsh,et al.  Site-specific protein labeling by Sfp phosphopantetheinyl transferase , 2006, Nature Protocols.

[55]  T. N. Bhat,et al.  The Protein Data Bank , 2000, Nucleic Acids Res..