A case of extra-gastrointestinal infection by Anisakis in a woman living in Catania (Sicily, Southern Italy) is described. The patient complained of severe pain in the ileocecal region, and a diagnosis of acute appendicitis led to an appendectomy. During the intervention, a laparoscopic exploration showed a nodule on the large omentum that was surgically removed. Parasitological diagnosis was achieved on the basis of morphological observations carried out on the histological sections of the nodule.