Control of the immune response

According to the Jerne hypothesis, the control of the immune response is due to interactions among anti-idiotypic antibodies which recognise each other. The authors present a model based on a network of interacting binary automata and compare its dynamics with the evolution of a typical auto-immune disease, experimental auto-immune encephalomyelitis.

[1]  I. Cohen.  Regulation of Autoimmune Disease Physiological and Therapeutic , 1986, Immunological reviews.

[2]  N. K. Jerne,et al.  The immune system. , 1973, Scientific American.

[3]  Daniel E. Koshland,et al.  Protein Shape and Biological Control , 1973 .