Invasion and metastasis

[1]  V. Murty,et al.  ERBB 2 ( HER 2 / neu ) Oncogene Is Frequently Amplified in Squamous Cell Carcinoma of the Uterine Cervix ' , 2006 .

[2]  L. Matrisian,et al.  Matrix degrading metalloproteinases , 2005, Journal of Neuro-Oncology.

[3]  T. Morris,et al.  Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models. , 1995, Cancer research.

[4]  P. Verde,et al.  Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer. , 1995, Oncogene.

[5]  M. Karin,et al.  Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. , 1995, Science.

[6]  P. Chambon,et al.  Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[7]  R. Muschel,et al.  The effect of E1A transfection on MMP‐9 expression and metastatic potential , 1995, International journal of cancer.

[8]  E. Lengyel,et al.  Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts. , 1995, Cancer research.

[9]  J. Olefsky,et al.  The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. , 1994, The Journal of biological chemistry.

[10]  G L Johnson,et al.  Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.

[11]  E. Sturgis,et al.  Effects of antiepidermal growth factor receptor antibody 528 on the proliferation and differentiation of head and neck cancer. , 1994, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[12]  C. Hauser,et al.  Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. , 1994, Oncogene.

[13]  M. Karin,et al.  c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK , 1994, Nature.

[14]  Michael J. Fry,et al.  Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.

[15]  N. Ahn,et al.  Transformation of mammalian cells by constitutively active MAP kinase kinase. , 1994, Science.

[16]  Motoharu Seiki,et al.  A matrix metalloproteinase expressed on the surface of invasive tumour cells , 1994, Nature.

[17]  Y. Nagamine,et al.  Multiple instability-regulating sites in the 3' untranslated region of the urokinase-type plasminogen activator mRNA , 1994, Molecular and cellular biology.

[18]  W. Hong,et al.  Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. , 1994, Cancer research.

[19]  M. Karin.  Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. , 1994, Current opinion in cell biology.

[20]  S. Gruber,et al.  Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Kolesnick,et al.  The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling , 1994, Cell.

[22]  S. Rabbani,et al.  Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. , 1994, Cancer research.

[23]  R. Chaganti,et al.  ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix. , 1994, Cancer research.

[24]  C. Bucana,et al.  Regulation of Gelatinase Production in Metastatic Renal Cell Carcinoma by Organ‐specific Fibroblasts , 1994, Japanese journal of cancer research : Gann.

[25]  R. Whyte,et al.  Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas. , 1994, The Journal of thoracic and cardiovascular surgery.

[26]  M. Birrer,et al.  Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[27]  C. Crews,et al.  Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[28]  T. Tsuruo,et al.  Serum and plasma M(r) 92,000 progelatinase levels correlate with spontaneous metastasis of rat 13762NF mammary adenocarcinoma. , 1993, Cancer research.

[29]  H. Sato,et al.  v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. , 1993, The Journal of biological chemistry.

[30]  C. Clavel,et al.  Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas. , 1993, Pathology, research and practice.

[31]  H. Birkedal‐Hansen,et al.  Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes. , 1993, The Journal of biological chemistry.

[32]  N. Maihle,et al.  Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases , 1993, Molecular and cellular biology.

[33]  G. Nicolson,et al.  Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity , 1993, International journal of cancer.

[34]  J. Grandis,et al.  Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. , 1993, Cancer research.

[35]  E. Adashi,et al.  Cytokine-mediated regulation of rat ovarian function: interleukin-1 stimulates the accumulation of a 92-kilodalton gelatinase. , 1993, Endocrinology.

[36]  P. Comoglio,et al.  Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. , 1993, The Journal of biological chemistry.

[37]  J. Hofsteenge,et al.  Purification and cDNA cloning of a transcription factor which functionally cooperates within a cAMP regulatory unit in the porcine uPA gene. , 1993, Nucleic acids research.

[38]  G. Nicolson,et al.  Regulation of urokinase‐type plasminogen activator expression in squamous‐cell carcinoma of the oral cavity , 1993, International journal of cancer.

[39]  Y. Sasaguri,et al.  Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor. , 1993, British Journal of Cancer.

[40]  M. Birrer,et al.  Suppression of oncogene-induced transformation by a deletion mutant of c-jun. , 1993, Oncogene.

[41]  M. Cobb,et al.  Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. , 1993, The Journal of biological chemistry.

[42]  H. Sato,et al.  Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. , 1993, Oncogene.

[43]  Catherine,et al.  Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. , 1993, Cancer research.

[44]  A. Mazar,et al.  Expression of Urokinase and Its Receptor in Invasive and Non-Invasive Prostate Cancer Cell Lines , 1992, Thrombosis and Haemostasis.

[45]  P. Verde,et al.  A regulatory element that mediates co‐operation between a PEA3‐AP‐1 element and an AP‐1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. , 1992, The EMBO journal.

[46]  R. Cardiff,et al.  Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. Liyanage,et al.  Activation of the c-Raf protein kinase by protein kinase C phosphorylation. , 1992, Oncogene.

[48]  C. Crews,et al.  The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. , 1992, Science.

[49]  L. Orci,et al.  Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells. , 1992, The Journal of biological chemistry.

[50]  M. Hung,et al.  Oral cancer progression and c-erbB-2/neu proto-oncogene expression. , 1992, Cancer letters.

[51]  L. Liotta,et al.  Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. , 1992, Cancer research.

[52]  R. Wilkins,et al.  Interstitial collagenase gene expression in oral squamous cell carcinoma. , 1992, The American journal of pathology.

[53]  David L. Brautigan,et al.  Raf-1 activates MAP kinase-kinase , 1992, Nature.

[54]  A. Sharrocks,et al.  Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter , 1992, Nature.

[55]  J. Heitman.  How the EcoRI endonuclease recognizes and cleaves DNA , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[56]  R. Kefford,et al.  Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells. , 1992, Cancer research.

[57]  U. Rapp,et al.  Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. , 1992, Genes & development.

[58]  A. Strongin,et al.  Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin. , 1992, The Journal of biological chemistry.

[59]  P. Jensen,et al.  Urokinase plasminogen activator is immunocytochemically detectable in squamous cell but not basal cell carcinomas. , 1992, The Journal of investigative dermatology.

[60]  T. Hurskainen,et al.  Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization. , 1992, Cancer research.

[61]  U. Zabel,et al.  A novel complex between the p65 subunit of NF‐kappa B and c‐Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. , 1992, The EMBO journal.

[62]  M. Roudebush,et al.  Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. , 1991, Oncogene.

[63]  M. Hung,et al.  Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells. , 1991, Oncogene.

[64]  J. Saurat,et al.  Differential protease expression by cutaneous squamous and basal cell carcinomas. , 1991, The Journal of clinical investigation.

[65]  L. Chow,et al.  Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells. , 1991, The Journal of biological chemistry.

[66]  P. Rørth,et al.  Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity. , 1991, Oncogene.

[67]  J. Wrana,et al.  Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. , 1991, The Journal of biological chemistry.

[68]  J. Abecassis,et al.  Expression of collagenase‐related metalloproteinase genes in human lung or head and neck tumours , 1991, International journal of cancer.

[69]  D. Gerhard,et al.  On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes. , 1991, Genomics.

[70]  C. Clavel,et al.  Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization. , 1991, Invasion & metastasis.

[71]  R. Schultz,et al.  Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes. , 1990, Cancer research.

[72]  P. Rørth,et al.  Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. , 1990, Nucleic acids research.

[73]  K. Yoneda,et al.  Basement membrane type IV collagen in oral squamous cell carcinoma , 1990, Head & neck.

[74]  L. Chow,et al.  Structure of the human type IV collagenase gene. , 1990, The Journal of biological chemistry.

[75]  R. Muschel,et al.  Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells. , 1990, Cancer research.

[76]  P. Verde,et al.  Follicle-stimulating hormone and cyclic AMP induce transcription from the human urokinase promoter in primary cultures of mouse Sertoli cells. , 1990, Molecular endocrinology.

[77]  D. von der Ahe,et al.  Macromolecular interaction on a cAMP responsive region in the urokinase-type plasminogen activator gene: a role of protein phosphorylation. , 1990, Nucleic acids research.

[78]  S. Frisch,et al.  Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells. , 1990, Oncogene.

[79]  A. Eisen,et al.  SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. , 1989, The Journal of biological chemistry.

[80]  K. Matsumoto,et al.  A study of an in vitro model for invasion of oral squamous cell carcinoma. , 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[81]  H. Suzuki,et al.  Resistance to oncogenic transformation in revertant R1 of human ras-transformed NIH 3T3 cells , 1989, Molecular and cellular biology.

[82]  M. Kraus,et al.  Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases. , 1989, Oncogene.

[83]  K. Suzuki,et al.  Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin). , 1988, The Biochemical journal.

[84]  P. Verde,et al.  An upstream enhancer and a negative element in the 5' flanking region of the human urokinase plasminogen activator gene. , 1988, Nucleic acids research.

[85]  T. Salo,et al.  Proteolytic degradation of extracellular matrix in tumor invasion. , 1987, Biochimica et biophysica acta.

[86]  W. McGuire,et al.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. , 1987, Science.

[87]  G. Grimaldi,et al.  Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells. , 1986, The EMBO journal.

[88]  N. Nomura,et al.  Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor , 1986, Nature.

[89]  T. Suyama,et al.  Primary structure of single-chain pro-urokinase. , 1985, The Journal of biological chemistry.

[90]  R. Weinberg,et al.  The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. , 1985, Science.

[91]  P. Verde,et al.  The human urokinase-plasminogen activator gene and its promoter. , 1985, Nucleic acids research.

[92]  P. Verde,et al.  Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[93]  L. Ossowski,et al.  Antibodies to plasminogen activator inhibit human tumor metastasis , 1983, Cell.

[94]  L. Liotta,et al.  Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis , 1982, International journal of cancer.

[95]  L. Liotta,et al.  Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. , 1981, Cancer research.

[96]  K. Robbins,et al.  The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin. , 1967, The Journal of biological chemistry.