Prevalence of viral gastroenteritis in children with acute gastroenteritis in Babol, Iran

Abstract Viral gastroenteritis is considered a significant cause of death and is a common cause of hospitalization worldwide. This study was performed to assess the role of rota, adeno and astrovirus in children with acute diarrhea in one main children's hospital in Amirkola, Babol North of Iran. In this cross-sectional study, stool specimens from 208 children suffering from acute diarrhea referred to Amirkola children's hospital were tested for the presence of rota, adeno and astrovirus by a monoclonal antibody-based enzyme immunoassay. Demographic data were gathered by a questionnaire. The prevalence of viral causes of acute gastroenteritis was reported by relative frequency. Rota, adeno and astrovirus antigens were detected in 61.1%, 2.9% and 2.4% of patients respectively. Infants between 6 and 12 months of age were most frequently affected by rotavirus (29.8%) (P < 0.03). Rotavirus infection was significantly less frequent in summer and spring than winter and autumn (P < 0.0001). No significant difference was observed in rotavirus infection between male and female but the prevalence of adenovirus in girls was significantly higher than boys (P < 0.05). Rotavirus can be regarded as a major etiologic agent of acute diarrhea in children less than two years old at Amirkola children's hospital, Babol. Immunization may protect the children before their first symptomatic infection.

[1]  C. Colomba,et al.  Viral gastroenteritis in children hospitalised in Sicily, Italy , 2006, European Journal of Clinical Microbiology and Infectious Diseases.

[2]  X. Pang,et al.  Viral Etiology and Incidence of Acute Gastroenteritis in Young Children Attending Day-Care Centers , 2005, The Pediatric infectious disease journal.

[3]  P. Gerner-Smidt,et al.  Etiology of Diarrhea in Young Children in Denmark: a Case-Control Study , 2005, Journal of Clinical Microbiology.

[4]  David B. Huang.  Contagious acute gastrointestinal infections. , 2005, The New England journal of medicine.

[5]  A. Zarnani,et al.  Role of rotaviruses in children with acute diarrhea in Tehran, Iran. , 2004, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[6]  Mark A. Miller,et al.  Global Illness and Deaths Caused by Rotavirus Disease in Children , 2003, Emerging infectious diseases.

[7]  S. Okitsu,et al.  Epidemiological features of rotavirus infection among hospitalized children with gastroenteristis in Ho Chi Minh City, Vietnam , 2003, Journal of medical virology.

[8]  D. Bass,et al.  Astrovirus, Adenovirus, and Rotavirus in Hospitalized Children: Prevalence and Association With Gastroenteritis , 2002, Journal of pediatric gastroenterology and nutrition.

[9]  E. Mallet,et al.  Epidemiology of acute viral gastroenteritis in children hospitalized in Rouen, France. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  W. Karmaus,et al.  A prospective evaluation of community acquired gastroenteritis in paediatric practices: impact and disease burden of rotavirus infection , 2001, Archives of disease in childhood.

[11]  R. Glass,et al.  Astrovirus diarrhea in Egyptian children. , 2000, The Journal of infectious diseases.

[12]  V. Waters,et al.  Etiology of community-acquired pediatric viral diarrhea: a prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998. The Pediatric Rotavirus Epidemiology Study for Immunization Study Group. , 2000, The Pediatric infectious disease journal.

[13]  E. Wang,et al.  Rotavirus-associated diarrhea in outpatient settings and child care centers. The Greater Toronto Area/Peel Region PRESI Study Group. Pediatric Rotavirus Epidemiology Study for Immunization. , 2000, Archives of pediatrics & adolescent medicine.

[14]  E. Kohli,et al.  Prevalence of Group A Rotavirus, Human Calicivirus, Astrovirus, and Adenovirus Type 40 and 41 Infections among Children with Acute Gastroenteritis in Dijon, France , 1999, Journal of Clinical Microbiology.

[15]  D. Fleming,et al.  An estimate of the proportion of diarrhoeal disease episodes seen by general practitioners attributable to rotavirus in children under 5 y of age in England and Wales , 1999, Acta paediatrica (Oslo, Norway : 1992). Supplement.

[16]  G. Barnes,et al.  Etiology of Acute Gastroenteritis in Hospitalized Children in Melbourne, Australia, from April 1980 to March 1993 , 1998, Journal of Clinical Microbiology.

[17]  R. Holman,et al.  Hospitalizations associated with rotavirus diarrhea in the United States, 1993 through 1995: surveillance based on the new ICD-9-CM rotavirus-specific diagnostic code. , 1998, The Journal of infectious diseases.

[18]  R. Glass,et al.  Epidemiology of rotavirus diarrhoea in Africa: a review to assess the need for rotavirus immunization. , 1998, Bulletin of the World Health Organization.

[19]  R. Holman,et al.  Trends in hospitalizations for diarrhea in United States children from 1979 through 1992: estimates of the morbidity associated with rotavirus. , 1996, The Pediatric infectious disease journal.

[20]  D. Rolim,et al.  Adenovirus genome types isolated from stools of children with gastroenteritis in São Paulo, Brazil , 1995, Journal of medical virology.

[21]  K. Huberman,et al.  Epidemiology of enteric adenovirus infection in prospectively monitored Argentine families , 1992, Epidemiology and Infection.

[22]  C. Cárcamo,et al.  Detection of astrovirus in pediatric stool samples by immunoassay and RNA probe , 1991, Journal of clinical microbiology.

[23]  P. Echeverria,et al.  Astroviruses as a cause of gastroenteritis in children. , 1991, The New England journal of medicine.

[24]  T. Vesikari,et al.  A Prospective Study of Acute Diarrhoea in Finnish Children from Birth to 2 1/2 Years of Age , 1991, Acta paediatrica Scandinavica.

[25]  S. MárquezCalderón,et al.  Incidence of diarrhea among groups of children in the city of Seville , 1990 .

[26]  E. J. Perea Pĕrez,et al.  [Incidence of diarrhea among groups of children in the city of Seville]. , 1990, Anales espanoles de pediatria.

[27]  R. Glass,et al.  Global seasonality of rotavirus infections. , 1990, Bulletin of the World Health Organization.

[28]  G. Donelli,et al.  A three-year diagnostic and epidemiological study on viral infantile diarrhoea in Rome , 1988, Epidemiology and Infection.

[29]  H. Ferrari.  [Acute infectious diarrhea]. , 1982, Acta gastroenterologica Latinoamericana.