Suspension flow in microfluidic devices--a review of experimental techniques focussing on concentration and velocity gradients.

Microfluidic devices are an emerging technology for processing suspensions in e.g. medical applications, pharmaceutics and food. Compared to larger scales, particles will be more influenced by migration in microfluidic devices, and this may even be used to facilitate segregation and separation. In order to get most out of these completely new technologies, methods to experimentally measure (or compute) particle migration are needed to gain sufficient insights for rational design. However, the currently available methods only allow limited access to particle behaviour. In this review we compare experimental methods to investigate migration phenomena that can occur in microfluidic systems when operated with natural suspensions, having typical particle diameters of 0.1 to 10 μm. The methods are used to monitor concentration and velocity profiles of bidisperse and polydisperse suspensions, which are notoriously difficult to measure due to the small dimensions of channels and particles. Various methods have been proposed in literature: tomography, ultrasound, and optical analysis, and here we review and evaluate them on general dimensionless numbers related to process conditions and channel dimensions. Besides, eleven practical criteria chosen such that they can also be used for various applications, are used to evaluate the performance of the methods. We found that NMR and CSLM, although expensive, are the most promising techniques to investigate flowing suspensions in microfluidic devices, where one may be preferred over the other depending on the size, concentration and nature of the suspension, the dimensions of the channel, and the information that has to be obtained. The paper concludes with an outlook on future developments of measurement techniques.

[1]  Jean-Louis Maubois,et al.  Fractionation of globular milk fat by membrane microfiltration , 2000 .

[2]  Marcos Akira d’Ávila,et al.  Magnetic resonance imaging (MRI): a technique to study flow an microstructure of concentrated emulsions , 2005 .

[4]  Hakho Lee,et al.  Rapid detection and profiling of cancer cells in fine-needle aspirates , 2009, Proceedings of the National Academy of Sciences.

[5]  A. Heuer,et al.  過冷却Lennard‐Jones流体におけるホッピング:準ベイスン,待ち時間分布および拡散 , 2003 .

[6]  David Erickson,et al.  Towards numerical prototyping of labs-on-chip: modeling for integrated microfluidic devices , 2005 .

[7]  M. Loewenberg,et al.  Spatially extended FCS for visualizing and quantifying high-speed multiphase flows in microchannels. , 2007, Optics express.

[8]  Robert H. Davis.  Modeling of Fouling of Crossflow Microfiltration Membranes , 1992 .

[9]  Howard A Stone,et al.  Shear-induced diffusion of platelike particles in microchannels. , 2008, Physical review letters.

[10]  D. A. Christopher,et al.  A high-frequency pulsed-wave Doppler ultrasound system for the detection and imaging of blood flow in the microcirculation. , 1997, Ultrasound in medicine & biology.

[11]  W. Webb,et al.  Background rejection and signal-to-noise optimization in confocal and alternative fluorescence microscopes. , 1994, Applied optics.

[12]  Eiichi Fukushima,et al.  Velocity and concentration measurements in multiphase flows by NMR , 1989 .

[13]  T. Cleveland,et al.  The use of neutron tomography for the structural analysis of corn kernels , 2008 .

[14]  K. Rausch.  Front End to Backpipe: Membrane Technology in the Starch Processing Industry , 2002 .

[15]  Richard D. Rabbitt,et al.  Electric impedance spectroscopy using microchannels with integrated metal electrodes , 1999 .

[16]  I. Anno,et al.  Nondestructive evaluation of blood flow in a dialyzer using X-ray computed tomography , 2003, Journal of Artificial Organs.

[17]  J. R. Abbott,et al.  A constitutive equation for concentrated suspensions that accounts for shear‐induced particle migration , 1992 .

[18]  N. Malik,et al.  Particle tracking velocimetry in three-dimensional flows , 1993 .

[19]  M. Aritomi,et al.  Flow measurement on an oscillating pipe flow near the entrance using the UVP method , 2002 .

[20]  A. Chow,et al.  Shear‐induced particle migration in Couette and parallel‐plate viscometers: NMR imaging and stress measurements , 1994 .

[21]  S. G. Mason,et al.  The flow of suspensions through tubes: V. Inertial effects , 1966 .

[22]  Xiaodong Jia,et al.  Tomographic imaging of particulate systems , 2003 .

[23]  Robert L. Powell,et al.  Experimental techniques for multiphase flows , 2008 .

[24]  H. Qian,et al.  Single particle tracking. Analysis of diffusion and flow in two-dimensional systems. , 1991, Biophysical journal.

[25]  W. Webb,et al.  Thermodynamic Fluctuations in a Reacting System-Measurement by Fluorescence Correlation Spectroscopy , 1972 .

[26]  Henk Van As,et al.  Diffusional Properties of Methanogenic Granular Sludge: 1H NMR Characterization , 2003, Applied and Environmental Microbiology.

[27]  David Isaacson,et al.  Electrical Impedance Tomography , 2002, IEEE Trans. Medical Imaging.

[28]  A. Bhagat,et al.  Inertial microfluidics for continuous particle filtration and extraction , 2009 .

[29]  J. Hinrichs,et al.  On the usage of acoustic properties combined with an artificial neural network – A new approach of determining presence of dairy fouling , 2011 .

[30]  Alexandra Ros,et al.  Bioanalysis in structured microfluidic systems , 2006, Electrophoresis.

[31]  Charles J. Retallack,et al.  On bubbles rising through suspensions of solid particles , 2007 .

[32]  C. Gao,et al.  Mixing and segregation of microspheres in microchannel flows of mono- and bidispersed suspensions. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[33]  Mostafa Barigou,et al.  The Fluid Mechanics of Two-Phase Solid-Liquid Food Flows: A Review , 1997 .

[34]  F. Gauthier,et al.  Particle motions in non-Newtonian media , 1971 .

[35]  Mostafa Barigou,et al.  Concentric flow regime of solid-liquid food suspensions: theory and experiment , 2003 .

[36]  Eric R. Weeks,et al.  Development of particle migration in pressure-driven flow of a Brownian suspension , 2007, Journal of Fluid Mechanics.

[37]  Thomas J. Dougherty,et al.  A Mechanism for Non‐Newtonian Flow in Suspensions of Rigid Spheres , 1959 .

[38]  Sudhir K. Sastry,et al.  A REVIEW of PARTICLE BEHAVIOR IN TUBE FLOW: APPLICATIONS to ASEPTIC PROCESSING1 , 1987 .

[39]  A. Lee,et al.  Droplet microfluidics. , 2008, Lab on a chip.

[40]  G. Whitesides.  The origins and the future of microfluidics , 2006, Nature.

[41]  A. Acrivos,et al.  The shear-induced migration of particles in concentrated suspensions , 1987, Journal of Fluid Mechanics.

[42]  P. Worth Longest,et al.  Efficient computation of micro-particle dynamics including wall effects , 2004 .

[43]  Elisa Michelini,et al.  Field-flow fractionation in bioanalysis: A review of recent trends. , 2009, Analytica chimica acta.

[44]  J. Westerweel,et al.  Stereoscopic micro particle image velocimetry , 2006 .

[45]  Nuclear magnetic resonance measurement of shear-induced particle migration in Brownian suspensions , 2009 .

[46]  Harri Kytömaa,et al.  Theory of sound propagation in suspensions: a guide to particle size and concentration characterization , 1995 .

[47]  Arthur P. Berkhoff,et al.  Signal Processing in Acoustics and Audio , 2004 .

[48]  S. Manneville.  Recent experimental probes of shear banding , 2008, 0903.5389.

[49]  Michel L. Riethmuller,et al.  Extension of PIV to Super Resolution using PTV , 2001 .

[50]  R. V. D. Sman,et al.  Classification and evaluation of microfluidic devices for continuous suspension fractionation. , 2008, Advances in colloid and interface science.

[51]  Yehuda Salu,et al.  Turbulent diffusion from a quasi-kinematical point of view , 1977 .

[52]  Katsumi Kose,et al.  A real-time NMR image reconstruction system using echo-planar imaging and a digital signal processor , 1992 .

[53]  J. Sweedler,et al.  Microscale NMR. , 2002, Current opinion in chemical biology.

[54]  J. Giddings,et al.  Field-flow fractionation handbook , 2000 .

[55]  D. Mewes,et al.  Tomographic imaging of the phase distribution in two-phase slug flow , 1998 .

[56]  J. Rädler,et al.  Flow profile near a wall measured by double-focus fluorescence cross-correlation. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[57]  Richard D. Keane,et al.  Super-resolution particle imaging velocimetry , 1995 .

[58]  Min Chan Kim,et al.  Reconstruction algorithm of electrical impedance tomography for particle concentration distribution in suspension , 2004 .

[59]  Jeffrey F. Morris,et al.  Shear induced particle migration in binary colloidal suspensions , 2006 .

[60]  Jun Wang,et al.  Recent advances in electric analysis of cells in microfluidic systems , 2008, Analytical and bioanalytical chemistry.

[61]  B. Balcom,et al.  Parallel-plate RF resonator imaging of chemical shift resolved capillary flow. , 2010, Magnetic resonance imaging.

[62]  L. Bécu,et al.  High-frequency ultrasonic speckle velocimetry in sheared complex fluids , 2003, cond-mat/0311072.

[63]  Volker Buschmann,et al.  Fluorescence correlation spectroscopy for flow rate imaging and monitoring--optimization, limitations and artifacts. , 2005, Lab on a chip.

[64]  Y. Fujii,et al.  Differential Laser Doppler Velocimeter With Enhanced Range for Small Wavelength Sensitivity by Using Cascaded Mach–Zehnder Interferometers , 2010, Journal of Lightwave Technology.

[65]  James E. Maneval,et al.  Note: Nuclear magnetic resonance imaging for viscosity measurements , 1994 .

[66]  J. Lewis,et al.  Structure of colloidal gels during microchannel flow. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[67]  Yasushi Saito,et al.  Measurements of liquid–metal two-phase flow by using neutron radiography and electrical conductivity probe , 2005 .

[68]  J. Aubin,et al.  Current methods for characterising mixing and flow in microchannels , 2010 .

[69]  R. Pereira.  Additional effects on internal flow of non-Newtonian fluids in the presence of a particle , 2000 .

[70]  F. Gauthier,et al.  Particle Motions in Non‐Newtonian Media. II. Poiseuille Flow , 1971 .

[71]  P. J. Goetz,et al.  Acoustic Spectroscopy for Concentrated Polydisperse Colloids with High Density Contrast , 1996 .

[72]  A. Theberge,et al.  Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. , 2010, Angewandte Chemie.

[73]  Stuart J. Williams,et al.  Advances and applications on microfluidic velocimetry techniques , 2010 .

[74]  Philippe Coussot,et al.  Some Applications of Magnetic Resonance Imaging in Fluid Mechanics: Complex Flows and Complex Fluids , 2008 .

[75]  High-flux membrane separation using fluid skimming dominated convective fluid flow , 2011 .

[76]  Yohsuke Imai,et al.  Measurement of Individual Red Blood Cell Motions Under High Hematocrit Conditions Using a Confocal Micro-PTV System , 2009, Annals of Biomedical Engineering.

[77]  L. G. Leal,et al.  An experimental investigation of concentrated suspension flows in a rectangular channel , 1994, Journal of Fluid Mechanics.

[78]  José Miguel Aguilera,et al.  Applications of Microfluidic Devices in Food Engineering , 2008 .

[79]  B. Ackerson.  Shear induced order in equilibrium colloidal liquids , 1991 .

[80]  Luisa Ciobanu,et al.  Multiple echo NMR velocimetry: fast and localized measurements of steady and pulsatile flows in small channels. , 2007, Journal of magnetic resonance.

[81]  T. Narayanan,et al.  Spatial and temporal in situ evolution of the concentration profile during casein micelle ultrafiltration probed by small-angle X-ray scattering. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[82]  Xianfeng Fan,et al.  Labelling a single particle for positron emission particle tracking using direct activation and ion-exchange techniques , 2006 .

[83]  H. Kikura,et al.  Thermal behaviour and particle size evaluation of primary clusters in a water-based magnetic fluid , 2004 .

[84]  Eiichi Fukushima,et al.  Nuclear magnetic resonance as a tool to study flow , 1999 .

[85]  H. Nyquist,et al.  Certain Topics in Telegraph Transmission Theory , 1928, Transactions of the American Institute of Electrical Engineers.

[86]  W. Kerr,et al.  Rheological characterization of a model suspension during pipe flow using MRI , 1998 .

[87]  E. Prince,et al.  Neutron Scattering Instrumentation: A Tutorial Review , 2004 .

[88]  David T. Leighton,et al.  INERTIAL LIFT ON A MOVING SPHERE IN CONTACT WITH A PLANE WALL IN A SHEAR FLOW , 1995 .

[89]  J. Chaouki,et al.  Noninvasive Tomographic and Velocimetric Monitoring of Multiphase Flows , 1997 .

[90]  Lisa Ann Mondy,et al.  Techniques of measuring particle motions in concentrated suspensions , 1986 .

[91]  Roger T. Bonnecaze,et al.  Imaging of Particle Shear Migration With Electrical Impedance Tomography , 1997, Fluids Engineering.

[92]  Lars Büttner,et al.  Laser Doppler field sensor for high resolution flow velocity imaging without camera. , 2008, Applied optics.

[93]  Bioanalysis in Structured Microfluidic Systems: Electrophoresis , 2006 .

[94]  Georges Belfort,et al.  Lateral migration of spherical particles in porous flow channels: application to membrane filtration , 1984 .

[95]  José Miguel Aguilera,et al.  Why food microstructure , 2005 .

[96]  D. Beebe,et al.  A particle image velocimetry system for microfluidics , 1998 .

[97]  Preferential Transport of Soil Colloidal Particles: Physicochemical Effects on Particle Mobilization , 2004 .

[98]  M. Aritomi,et al.  Flow measurement on oscillating pipe flow near the entrance using the UVP method , 2003 .

[99]  K. Thompson,et al.  Spatial Gradients in Particle Reinforced Polymers Characterized by X-Ray Attenuation and Laser Confocal Microscopy , 2000 .

[100]  Jaesung Park,et al.  Optically sliced micro-PIV using confocal laser scanning microscopy (CLSM) , 2004 .

[101]  Eric R. Weeks,et al.  Particle migration in pressure-driven flow of a Brownian suspension , 2003, Journal of Fluid Mechanics.

[102]  D. Wildenschild,et al.  Imaging biofilm in porous media using X‐ray computed microtomography , 2011, Journal of microscopy.

[103]  H. Stone,et al.  Geometrical focusing of cells in a microfluidic device: an approach to separate blood plasma. , 2006, Biorheology.

[104]  S Schöder,et al.  Time-resolved microfocused small-angle X-ray scattering investigation of the microfluidic concentration of charged nanoparticles , 2011, The European physical journal. E, Soft matter.

[105]  N. Thompson,et al.  Recent advances in fluorescence correlation spectroscopy. , 2002, Current opinion in structural biology.

[106]  A. Imhof,et al.  A new parallel plate shear cell for in situ real-space measurements of complex fluids under shear flow. , 2007, The Review of scientific instruments.

[107]  J. Westerweel.  Fundamentals of digital particle image velocimetry , 1997 .

[108]  S. Bhattacharjee,et al.  Motion of a spherical particle in a cylindrical channel using arbitrary Lagrangian-Eulerian method. , 2008, Journal of colloid and interface science.

[109]  R. V. D. Sman,et al.  Suspension flow modelling in particle migration and microfiltration , 2010 .

[110]  J. Kromkamp.  Particle separation and fractionation by microfiltration , 2005 .

[111]  Eric R. Weeks,et al.  Confocal microscopy of colloids , 2007 .

[112]  Young Won Kim,et al.  RECENT EXPERIMENTAL STUDIES ON MICROSCALE CHANNEL FLOWS , 2008 .

[113]  V. Prasad,et al.  Three-dimensional confocal microscopy of colloids. , 2001, Applied optics.

[114]  D. Derks,et al.  Confocal microscopy of colloidal dispersions in shear flow using a counter-rotating cone-plate shear cell , 2004 .

[115]  Michael C. Petty,et al.  Effect of composition on the electrical conductance of milk , 2003 .

[116]  C. Willert,et al.  Digital particle image velocimetry , 1991 .

[117]  N. Selçuk,et al.  Effect of particle polydispersity on particle concentration measurement by using laser Doppler anemometry , 2007 .

[118]  Robert A. Novelline,et al.  Squire's Fundamentals of Radiology , 2018 .

[119]  W. D. Bachalo,et al.  Experimental methods in multiphase flows , 1994 .

[120]  Kaichiro Mishima,et al.  Development of high-frame-rate neutron radiography and quantitative measurement method for multiphase flow research , 1998 .

[121]  J A Rowlands,et al.  X-ray detectors for digital radiography. , 1997, Physics in medicine and biology.

[122]  D. Di Carlo,et al.  Sheathless inertial cell ordering for extreme throughput flow cytometry. , 2010, Lab on a chip.

[123]  L. Gary Leal,et al.  An experimental study of the motion of concentrated suspensions in two-dimensional channel flow. Part 2. Bidisperse systems , 1998, Journal of Fluid Mechanics.

[124]  A. A. Adamczyk,et al.  2-Dimensional particle tracking velocimetry (PTV): Technique and image processing algorithms , 1988 .

[125]  S. Wereley,et al.  PIV measurements of a microchannel flow , 1999 .

[126]  A. N. Garroway,et al.  Velocity measurements in flowing fluids by MNR , 1974 .

[127]  K. J. Packer,et al.  Pulsed NMR studies of restricted diffusion. I. Droplet size distributions in emulsions , 1972 .

[128]  S. Quake,et al.  Microfluidics: Fluid physics at the nanoliter scale , 2005 .

[129]  A. Melling,et al.  Principles and practice of laser-Doppler anemometry , 1976 .

[130]  E Gratton,et al.  Two-photon fluorescence correlation spectroscopy: method and application to the intracellular environment. , 1995, Biophysical journal.

[131]  Mehmet Toner,et al.  Blood-on-a-chip. , 2005, Annual review of biomedical engineering.

[132]  R. Pal.  Techniques for measuring the composition (oil and water content) of emulsions — a state of the art review , 1994 .

[133]  Experimental studies of the flow of concentrated hard sphere suspensions into a constriction , 2006 .

[134]  C N Chen,et al.  The field dependence of NMR imaging. II. Arguments concerning an optimal field strength , 1986, Magnetic resonance in medicine.

[135]  Jonathan Leach,et al.  Multipoint holographic optical velocimetry in microfluidic systems , 2006, SPIE Optics + Photonics.

[136]  Yong Jin,et al.  Application of Doppler ultrasound velocimetry in multiphase flow , 2003 .

[137]  Eiichi Fukushima,et al.  Velocity and concentration measurements of suspensions by nuclear magnetic resonance imaging , 1991 .

[138]  Eric R Weeks,et al.  Quantitative imaging of colloidal flows. , 2008, Advances in colloid and interface science.

[139]  Arjen Schots,et al.  Design of a confocal microfluidic particle sorter using fluorescent photon burst detection , 2004 .

[140]  M. Yamada,et al.  Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. , 2004, Analytical chemistry.