When translation meets transformation: the mTOR story

[1]  P. Houghton,et al.  mTOR as a Target for Cancer Therapy , 2008 .

[2]  O. Meyuhas,et al.  Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. , 2006, Trends in biochemical sciences.

[3]  R. Rhoads,et al.  Stopped-flow Kinetic Analysis of eIF4E and Phosphorylated eIF4E Binding to Cap Analogs and Capped Oligoribonucleotides , 2006, Journal of Biological Chemistry.

[4]  V. Hwa,et al.  Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. , 2006, Experimental cell research.

[5]  A. Wong,et al.  Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. , 2006, Endocrinology.

[6]  D. Sabatini,et al.  Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. , 2006, Molecular cell.

[7]  J. Shabanowitz,et al.  mTOR‐dependent stimulation of the association of eIF4G and eIF3 by insulin , 2006, The EMBO journal.

[8]  Shengkan Jin,et al.  A Matter of Life or Death (or Both): Understanding Autophagy in Cancer , 2006, Clinical Cancer Research.

[9]  Haiyan Zhang,et al.  Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. , 2006, Cancer research.

[10]  S. Pattingre,et al.  Bcl-2 inhibition of autophagy: a new route to cancer? , 2006, Cancer research.

[11]  L. Klampfer,et al.  Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs. , 2006, Current cancer drug targets.

[12]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[13]  J. Blenis,et al.  TORgeting oncogene addiction for cancer therapy. , 2006, Cancer cell.

[14]  D. Sabatini,et al.  Growing roles for the mTOR pathway. , 2005, Current opinion in cell biology.

[15]  Toshimasa Ishida,et al.  Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. , 2005, Biochimica et biophysica acta.

[16]  Steven P. Gygi,et al.  mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.

[17]  C. Proud,et al.  Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties* , 2005, Journal of Biological Chemistry.

[18]  F. Natt,et al.  Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[19]  James T. Murray,et al.  hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase* , 2005, Journal of Biological Chemistry.

[20]  Yuval Dor,et al.  Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. , 2005, Genes & development.

[21]  N. Sonenberg,et al.  A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay , 2005, The Journal of cell biology.

[22]  David M Sabatini,et al.  An expanding role for mTOR in cancer. , 2005, Trends in molecular medicine.

[23]  Jingxiang Huang,et al.  The significance of autophagy in cancer , 2005, Molecular carcinogenesis.

[24]  M. Clemens,et al.  Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53 , 2005, Oncogene.

[25]  A. Levine,et al.  The coordinate regulation of the p53 and mTOR pathways in cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Proud.  The eukaryotic initiation factor 4E-binding proteins and apoptosis , 2005, Cell Death and Differentiation.

[27]  D. Sabatini,et al.  Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦ , 2005, Journal of Biological Chemistry.

[28]  C. Proud,et al.  The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses* , 2005, Journal of Biological Chemistry.

[29]  M. Zamora,et al.  Translation of Eukaryotic Translation Initiation Factor 4GI (eIF4GI) Proceeds from Multiple mRNAs Containing a Novel Cap-dependent Internal Ribosome Entry Site (IRES) That Is Active during Poliovirus Infection* , 2005, Journal of Biological Chemistry.

[30]  K. Borden,et al.  eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR , 2005, The Journal of cell biology.

[31]  Paul Tempst,et al.  Phosphorylation and Functional Inactivation of TSC2 by Erk Implications for Tuberous Sclerosisand Cancer Pathogenesis , 2005, Cell.

[32]  M. Murakami,et al.  Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins , 2005, Molecular and Cellular Biology.

[33]  J. Blenis,et al.  Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation* , 2005, Journal of Biological Chemistry.

[34]  K. Borden,et al.  Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities , 2004, Cancer Research.

[35]  P. Codogno,et al.  Regulation and role of autophagy in mammalian cells. , 2004, The international journal of biochemistry & cell biology.

[36]  B. Manning.  Balancing Akt with S6K , 2004, The Journal of cell biology.

[37]  R. Loewith,et al.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.

[38]  V. Gonzalez,et al.  Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. , 2004, Experimental cell research.

[39]  C. Haipek,et al.  Functional significance of S6K overexpression in meningioma progression , 2004, Annals of neurology.

[40]  S. Nagata,et al.  Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development , 2004, Molecular and Cellular Biology.

[41]  N. Sonenberg,et al.  Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. , 2004, Cancer cell.

[42]  Peter J Houghton,et al.  Lost in translation: dysregulation of cap-dependent translation and cancer. , 2004, Cancer cell.

[43]  J. Blenis,et al.  ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions , 2004, Microbiology and Molecular Biology Reviews.

[44]  M. Peterson,et al.  Translation Initiation Factor 4E Blocks Endoplasmic Reticulum-mediated Apoptosis* , 2004, Journal of Biological Chemistry.

[45]  J. Stȩpiński,et al.  Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus. , 2004, Biochemistry.

[46]  P. Pandolfi,et al.  The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis , 2004, Nature Medicine.

[47]  A. Gingras,et al.  Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases , 2004, The EMBO journal.

[48]  N. Sonenberg,et al.  eIF4E – from translation to transformation , 2004, Oncogene.

[49]  M. Clemens,et al.  Targets and mechanisms for the regulation of translation in malignant transformation , 2004, Oncogene.

[50]  E. Schmidt.  The role of c-myc in regulation of translation initiation , 2004, Oncogene.

[51]  J. Graff,et al.  eIF-4E expression and its role in malignancies and metastases , 2004, Oncogene.

[52]  Christopher G. Proud,et al.  A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin , 2004, Molecular and Cellular Biology.

[53]  Stefano Fumagalli,et al.  S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway , 2004, Molecular and Cellular Biology.

[54]  S. Lowe,et al.  Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy , 2004, Nature.

[55]  I. Grummt,et al.  mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. , 2004, Genes & development.

[56]  E. Schmidt,et al.  Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth* , 2004, Journal of Biological Chemistry.

[57]  J. Blenis,et al.  mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E , 2004, Molecular and Cellular Biology.

[58]  R. Pearson,et al.  mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF† , 2003, Molecular and Cellular Biology.

[59]  I. Mothe-Satney,et al.  Ser-64 and Ser-111 in PHAS-I Are Dispensable for Insulin-stimulated Dissociation from eIF4E* , 2003, Journal of Biological Chemistry.

[60]  G. Scheper,et al.  Features in the N and C Termini of the MAPK-interacting Kinase Mnk1 Mediate Its Nucleocytoplasmic Shuttling* , 2003, Journal of Biological Chemistry.

[61]  C. Proud,et al.  Target of Rapamycin (TOR)-signaling and RAIP Motifs Play Distinct Roles in the Mammalian TOR-dependent Phosphorylation of Initiation Factor 4E-binding Protein 1* , 2003, Journal of Biological Chemistry.

[62]  G. Scheper,et al.  The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization , 2003, Molecular and Cellular Biology.

[63]  C. Proud,et al.  The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory Features That Influence Its Function and Phosphorylation , 2003, Molecular and Cellular Biology.

[64]  K. Borden,et al.  The proline‐rich homeodomain protein, PRH, is a tissue‐specific inhibitor of eIF4E‐dependent cyclin D1 mRNA transport and growth , 2003, The EMBO journal.

[65]  M. Peterson,et al.  Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochromec Release* , 2003, The Journal of Biological Chemistry.

[66]  G. Scheper,et al.  Localisation and regulation of the eIF4E‐binding protein 4E‐BP3 , 2002, FEBS letters.

[67]  C. Proud,et al.  Regulation of peptide-chain elongation in mammalian cells. , 2002, European journal of biochemistry.

[68]  Christopher G. Proud,et al.  Does phosphorylation of the cap‐binding protein eIF4E play a role in translation initiation? , 2002, European journal of biochemistry.

[69]  K. Borden,et al.  Gamma Interferon and Cadmium Treatments Modulate Eukaryotic Initiation Factor 4E-Dependent mRNA Transport of Cyclin D1 in a PML-Dependent Manner , 2002, Molecular and Cellular Biology.

[70]  M. Clemens,et al.  p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation , 2002, Oncogene.

[71]  J. Blenis,et al.  Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. , 2002, Genes & development.

[72]  J. Blenis,et al.  Identification of a Conserved Motif Required for mTOR Signaling , 2002, Current Biology.

[73]  B. Chait,et al.  Mass Spectrometric Analysis of the N Terminus of Translational Initiation Factor eIF4G-1 Reveals Novel Isoforms* , 2002, The Journal of Biological Chemistry.

[74]  C. Proud,et al.  The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites* , 2002, The Journal of Biological Chemistry.

[75]  K. Borden,et al.  The emerging roles of translation factor eIF4E in the nucleus. , 2002, Differentiation; research in biological diversity.

[76]  C. Proud,et al.  Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif , 2002, Molecular and Cellular Biology.

[77]  G. Scheper,et al.  Phosphorylation of Eukaryotic Initiation Factor 4E Markedly Reduces Its Affinity for Capped mRNA* , 2002, The Journal of Biological Chemistry.

[78]  A. Calastretti,et al.  Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect. , 2001, European journal of cancer.

[79]  A. Kentsis,et al.  The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. , 2001, Journal of molecular biology.

[80]  S. Capaccioli,et al.  Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase , 2001, Oncogene.

[81]  Philip R. Cohen,et al.  A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ , 2001, The EMBO journal.

[82]  C. Proud,et al.  Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase , 2001, The EMBO journal.

[83]  A. Kentsis,et al.  PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA , 2001, The EMBO journal.

[84]  C. Proud,et al.  Staurosporine inhibits phosphorylation of translational regulators linked to mTOR , 2001, Cell Death and Differentiation.

[85]  G. Scheper,et al.  The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells , 2001, Molecular and Cellular Biology.

[86]  R. Burcelin,et al.  Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.

[87]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[88]  R. Abraham,et al.  Mammalian Target of Rapamycin-dependent Phosphorylation of PHAS-I in Four (S/T)P Sites Detected by Phospho-specific Antibodies* , 2000, The Journal of Biological Chemistry.

[89]  A. Gingras,et al.  Translational Control of the Antiapoptotic Function of Ras* , 2000, The Journal of Biological Chemistry.

[90]  C. Proud,et al.  DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling , 2000, Oncogene.

[91]  N. Sonenberg,et al.  A novel shuttling protein, 4E‐T, mediates the nuclear import of the mRNA 5′ cap‐binding protein, eIF4E , 2000, The EMBO journal.

[92]  R. Fåhraeus,et al.  Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E , 2000, Current Biology.

[93]  T. Haystead,et al.  Multiple Mechanisms Control Phosphorylation of PHAS-I in Five (S/T)P Sites That Govern Translational Repression , 2000, Molecular and Cellular Biology.

[94]  M. MacFarlane,et al.  Initiation of Apaf-1 translation by internal ribosome entry , 2000, Oncogene.

[95]  S. Gygi,et al.  Serum‐stimulated, rapamycin‐sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI , 2000, The EMBO journal.

[96]  H. Koh,et al.  Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt , 1999, Oncogene.

[97]  C. Proud,et al.  Rapamycin‐resistant phosphorylation of the initiation factor‐4E‐binding protein (4E‐BP1) in v‐SRC‐transformed hamster fibroblasts , 1999, International journal of cancer.

[98]  Jonathan A. Cooper,et al.  Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo , 1999, Molecular and Cellular Biology.

[99]  A. Gingras,et al.  Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E , 1999, The EMBO journal.

[100]  M. Ward,et al.  Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer , 1999, British Journal of Cancer.

[101]  M. Andjelkovic,et al.  Phosphorylation and activation of p70s6k by PDK1. , 1998, Science.

[102]  Dario R. Alessi,et al.  3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro , 1998, Current Biology.

[103]  M Wiedmann,et al.  Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[104]  J. Eberle,et al.  Translation initiation factor eIF‐4A1 mRNA is consistently overexpressed in human melanoma cells in vitro , 1997, International journal of cancer.

[105]  Jonathan A. Cooper,et al.  Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 , 1997, The EMBO journal.

[106]  Tony Hunter,et al.  MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates , 1997, The EMBO journal.

[107]  N. Sonenberg,et al.  Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc , 1996, Molecular and cellular biology.

[108]  C. Proud,et al.  Regulation of translation elongation factor‐2 by insulin via a rapamycin‐sensitive signalling pathway. , 1996, The EMBO journal.

[109]  N. Sonenberg,et al.  Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[110]  C. Proud,et al.  Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells (*) , 1995, The Journal of Biological Chemistry.

[111]  R. Rhoads,et al.  Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209 (*) , 1995, The Journal of Biological Chemistry.

[112]  N. Sonenberg,et al.  mRNAs containing extensive secondary structure in their 5′ non‐coding region translate efficiently in cells overexpressing initiation factor eIF‐4E. , 1992, The EMBO journal.

[113]  O. Nygård,et al.  Functional properties of phosphorylated elongation factor 2. , 1990, European journal of biochemistry.

[114]  N. Sonenberg,et al.  Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap , 1990, Nature.

[115]  I. Wool,et al.  The stimulation of the phosphorylation of ribosomal protein S6 by cycloheximide and puromycin. , 1974, Biochemical and biophysical research communications.

[116]  I. Mellinghoff,et al.  Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer , 2006, Nature Medicine.

[117]  S. Kimball,et al.  Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. , 2006, The Journal of nutrition.

[118]  S. Zimmer,et al.  Translational control and metastatic progression: Enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs , 2004, Clinical & Experimental Metastasis.

[119]  J. Avruch,et al.  The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. , 2001, Progress in molecular and subcellular biology.

[120]  J. Avruch,et al.  Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR , 2000, Current Biology.

[121]  A. Gingras,et al.  eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. , 1999, Annual review of biochemistry.

[122]  A. Bauer,et al.  The FASEB Journal • Research Communication Calcium signaling stimulates translation of ��F-� during hypoxia , 2022 .