Assessment of Health-Related Quality of Life in Pediatric Acute Lymphoblastic Leukemia Survivors: Perceptions of Children, Siblings, and Parent

Address for Correspondence/Yazışma Adresi: Hale ÖREN, M.D., Dokuz Eylül University Faculty of Medicine, Department of Pediatric Hematology, İzmir, Turkey Phone : +90 232 412 61 41 E-mail : hale.oren@deu.edu.tr ORCID-ID: orcid.org/0000-0001-5760-8007 Received/Geliş tarihi: October 10, 2018 Accepted/Kabul tarihi: November 06, 2018 ©Copyright 2019 by Turkish Society of Hematology Turkish Journal of Hematology, Published by Galenos Publishing House Introduction Acute lymphoblastic leukemia (ALL) comprises 26%-28% of all childhood malignancies [1,2]. The outcome of ALL has improved and survival periods have become longer [3,4]. Five-year overall survival was 79.9% at our centers between 1995 and 2009 [5]. Investigations of survivors have documented that their quality of life is negatively affected, with difficulties in social and intellectual functioning [6,7,8,9,10]. The aim of this study was to investigate health-related quality of life (HRQL) in survivors of pediatric ALL and to evaluate the perceptions of the children, their siblings, and their parents.

[1]  M. Grootenhuis,et al.  Health-related quality of life of survivors of childhood acute lymphoblastic leukemia: a systematic review , 2018, Quality of Life Research.

[2]  R. Barr,et al.  Health-related quality of life in long-term survivors of acute lymphoblastic leukemia in childhood and adolescence , 2017, Quality of Life Research.

[3]  Melike Sezgin Evim,et al.  Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors , 2016, Turkish journal of haematology : official journal of Turkish Society of Haematology.

[4]  Lyn M. Balsamo,et al.  Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331 , 2016, International journal of cancer.

[5]  J. Downing,et al.  Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  P. Auquier,et al.  Health Status and Quality of Life of Long-term Survivors of Childhood Acute Leukemia: The Impact of Central Nervous System Irradiation , 2015, Journal of pediatric hematology/oncology.

[7]  R. Pieters,et al.  Determinants of quality of life during induction therapy in pediatric acute lymphoblastic leukemia , 2014, Supportive Care in Cancer.

[8]  H. Ören,et al.  The long-term results of childhood acute lymphoblastic leukemia at two centers from Turkey: 15 years of experience with the ALL-BFM 95 protocol , 2014, Annals of Hematology.

[9]  Carmen L. Wilson,et al.  Decline in Physical Activity Level in the Childhood Cancer Survivor Study Cohort , 2014, Cancer Epidemiology, Biomarkers & Prevention.

[10]  Lyn M. Balsamo,et al.  A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia , 2014, Cancer.

[11]  H. Ören,et al.  Assessment of Neuropsychological Late Effects in Survivors of Childhood Leukemia , 2014, Pediatric hematology and oncology.

[12]  S. Fosså,et al.  Factors associated with poor quality of life in survivors of childhood acute lymphoblastic leukemia and lymphoma , 2013, Pediatric blood & cancer.

[13]  J. Harbott,et al.  Key Treatment Questions in Childhood Acute Lymphoblastic Leukemia: Results in 5 Consecutive Trials Performed by the ALL-BFM Study Group From 1981 to 2000 , 2013, Klinische Pädiatrie.

[14]  G. Kaspers,et al.  Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia , 2013, Pediatric blood & cancer.

[15]  R. Gelber,et al.  Health‐related quality of life among children with acute lymphoblastic leukemia , 2012, Pediatric blood & cancer.

[16]  L. Robison Late effects of acute lymphoblastic leukemia therapy in patients diagnosed at 0-20 years of age. , 2011, Hematology. American Society of Hematology. Education Program.

[17]  Ulrika Pöder,et al.  Parents' perceptions of their children's cancer-related symptoms during treatment: a prospective, longitudinal study. , 2010, Journal of pain and symptom management.

[18]  C. Pui,et al.  ‘Educational symposium on long-term results of large prospective clinical trials for childhood acute lymphoblastic leukemia (1985–2000)’ , 2010, Leukemia.

[19]  G. Reaman,et al.  Late Effects in Long-Term Survivors After Treatment for Childhood Acute Leukemia , 2009, Clinical pediatrics.

[20]  L. Robison,et al.  Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. , 2008, Blood.

[21]  J. Ross,et al.  Trends in childhood cancer incidence in the U.S. (1992–2004) , 2008, Cancer.

[22]  Christian Urban,et al.  Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. , 2007, Blood.

[23]  D. Feeny,et al.  A structured review of studies on health-related quality of life and economic evaluation in pediatric acute lymphoblastic leukemia. , 2004, Journal of the National Cancer Institute. Monographs.

[24]  C. Eiser,et al.  Issues in measuring quality of life in childhood cancer: measures, proxies, and parental mental health. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[25]  M. Bullinger,et al.  Quality of life after in-patient rehabilitation in children with obesity , 2001, International Journal of Obesity.

[26]  M. Bullinger,et al.  [Subjective health and health behavior of children and adolescents--a survey of Hamburg students within the scope of school medical examination]. , 2000, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[27]  M. Bullinger,et al.  Assessing health-related quality of life in chronically ill children with the German KINDL: first psychometric and content analytical results , 1998, Quality of Life Research.

[28]  H. Zeeb,et al.  Cancer patterns among children of Turkish descent in Germany : A study at the German Childhood Cancer Registry , 2007 .

[29]  U. Ellert,et al.  [Health-related quality of life of children and adolescents in Germany. Norm data from the German Health Interview and Examination Survey (KiGGS)]. , 2007, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

[30]  Christine Eiser,et al.  Can parents rate their child's health-related quality of life? Results of a systematic review , 2004, Quality of Life Research.