Neuropathy endpoints

ues of about 10 mm Hg above those with conventional testing in our study. In 3 of 28 patients receiving CO, augmentation, we observed CO, values above 100 mm Hg after 2 or 3 minutes. The highest value after 1 minute was 89.0 mm Hg. Adopting the same criteria as in our article' (i.e., t test and p = 0.01), neither (A) nor (B) differed significantly between apnea testing with ( p = 0.020) and without ( p = 0.224) CO, augmentation. Because in each case we also applied apnea testing without CO, augmentation and observed the patient continuously for the full time of SIMVl respiration and thereafter while off the respirator, rapid CO, narcosis as the case of apnea is certainly excluded. We are now trying to reduce the target overshoot by adjustment of the rate of delivery of CO, and even closer monitoring.