mRNA Big Data Analysis of Hepatoma Carcinoma Between Different Genders

In this paper, we did the researches of the directly related differentially expression mRNAs (DEmRNAs) and their gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathway, COX model and survival analysis. For the purpose, the 87 directly related DEmRNAs (DRmRNAs) to the hepatoma carcinoma illness were selected from the intersectional DEmRNAs of normal-tumor sample matrix and male-female tumor's sample matrix. By the analysis of online databases, DAVID, KOBAS and KEGG, DRmRNAs were enriched in 18 biological process (BP), 5 cellular component (CC), 9 molecular function (MF) and 3 signal pathways (hsa04974, hsa04972 and hsa04080). The co-expression DRmRNAs were analyzed by using the COX model. CHGA was regard as a potential biomarker of hepatoma carcinoma by the proof of survival kmplot analysis and ROC curve analysis.

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