pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.

[1]  N. Packer,et al.  Studies on the “Insoluble” Glycoprotein Complex from Human Colon , 1999, The Journal of Biological Chemistry.

[2]  N. Moniaux,et al.  Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. , 1999, The Biochemical journal.

[3]  J. Dekker,et al.  Gastrointestinal expression and partial cDNA cloning of murine Muc2. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[4]  C. Tomasetto,et al.  The pS2/TFF1 trefoil factor, from basic research to clinical applications. , 1998, Biochimica et biophysica acta.

[5]  S. Poulsen,et al.  Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat , 1998, Gut.

[6]  G. Hansson,et al.  O-Glycosylated MUC2 Monomer and Dimer from LS 174T Cells Are Water-soluble, whereas Larger MUC2 Species Formed Early during Biosynthesis Are Insoluble and Contain Nonreducible Intermolecular Bonds* , 1998, The Journal of Biological Chemistry.

[7]  J. Dekker,et al.  Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. , 1998, Biochemical and biophysical research communications.

[8]  W. Bodmer,et al.  Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells , 1998 .

[9]  I. Gipson,et al.  Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains. , 1998, The Biochemical journal.

[10]  D. Podolsky,et al.  Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[11]  L. Thim.  Trefoil peptides: from structure to function , 1997, Cellular and Molecular Life Sciences CMLS.

[12]  F. May,et al.  Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. , 1997, The Biochemical journal.

[13]  F. May,et al.  Review: Trefoil Proteins: Their Role in Normal and Malignant Cells , 1997 .

[14]  W. Hsueh,et al.  Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: identification by in situ binding and ligand blotting. , 1997, Biochemical and biophysical research communications.

[15]  J. Dekker,et al.  Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. , 1997, The American journal of physiology.

[16]  L. Thim,et al.  Rolling in the clover: trefoil factor family (TFF)‐domain peptides, cell migration and cancer , 1997, FEBS letters.

[17]  T. Frenkiel,et al.  High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. , 1997, Journal of molecular biology.

[18]  R. Poulsom,et al.  Trefoil peptides: mitogens, motogens, or mirages? , 1997, Journal of clinical gastroenterology.

[19]  M. Fishman,et al.  Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor , 1996, Science.

[20]  P. Chambon,et al.  Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein , 1996, Science.

[21]  J. Lewis,et al.  A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. , 1996, Developmental biology.

[22]  R. Poulsom,et al.  Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  L. Thim,et al.  Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats. , 1996, Gastroenterology.

[24]  L. Mirels,et al.  Mouse submandibular gland salivary apomucin contains repeated N-glycosylation sites. , 1996, Glycobiology.

[25]  R. Chinery,et al.  Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor , 1995, Peptides.

[26]  C. Kozak,et al.  Mouse gastric mucin: cloning and chromosomal localization. , 1995, The Biochemical journal.

[27]  Hong Wang,et al.  Yeast Two-hybrid System Demonstrates That Estrogen Receptor Dimerization Is Ligand-dependent in Vivo(*) , 1995, The Journal of Biological Chemistry.

[28]  L. Thim,et al.  Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. , 1995, Gastroenterology.

[29]  Y. Kim,et al.  Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. , 1995, Cancer research.

[30]  L. Thim,et al.  Characterization of human and rat intestinal trefoil factor produced in yeast. , 1995, Biochemistry.

[31]  R. Playford,et al.  Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat. , 1995, Clinical science.

[32]  P. Bates,et al.  Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers , 1995, FEBS letters.

[33]  S. Gendler,et al.  Epithelial mucin genes. , 1995, Annual review of physiology.

[34]  R. Playford,et al.  Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. , 1995, Gastroenterology.

[35]  J. Dekker,et al.  Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. , 1994, Gastroenterology.

[36]  S. Fields,et al.  The two-hybrid system: an assay for protein-protein interactions. , 1994, Trends in genetics : TIG.

[37]  L. Thim,et al.  Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. , 1994, The Journal of clinical investigation.

[38]  Y. Kim,et al.  Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. , 1994, Gastroenterology.

[39]  M. Polymeropoulos,et al.  Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). , 1994, The Journal of biological chemistry.

[40]  P. Chambon,et al.  pS2 and response to adjuvant hormone therapy in primary breast cancer. , 1994, British Journal of Cancer.

[41]  Y. Kim,et al.  Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. , 1994, The Journal of biological chemistry.

[42]  Z. Dauter,et al.  Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides. , 1993, Structure.

[43]  A. Biesbrock,et al.  Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). , 1993, The Journal of biological chemistry.

[44]  R. Poulsom,et al.  Trefoil peptides: a newly recognized family of epithelial mucin-associated molecules. , 1993, The American journal of physiology.

[45]  P. Bork.  The modular architecture of a new family of growth regulators related to connective tissue growth factor , 1993, FEBS letters.

[46]  Jonathan A. Cooper,et al.  Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.

[47]  F. Hauser,et al.  The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia? , 1993, Trends in biochemical sciences.

[48]  P. Chambon,et al.  The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression , 1993, The Journal of cell biology.

[49]  R. Lagacé,et al.  The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. , 1992, The Journal of biological chemistry.

[50]  D. Podolsky,et al.  Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[51]  S. Gendler,et al.  Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism. , 1991, The Journal of biological chemistry.

[52]  J. V. van Mourik,et al.  Assembly and routing of von Willebrand factor variants: the requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids , 1991, The Journal of cell biology.

[53]  N. Peat,et al.  Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. , 1990, The Journal of biological chemistry.

[54]  R. Lathe,et al.  Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. , 1988, Science.

[55]  E. Frandsen.  Receptor binding of pancreatic spasmolytic polypeptide in intestinal mucosal cells and membranes , 1988, Regulatory Peptides.

[56]  P Chambon,et al.  Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[57]  L. Thim,et al.  Receptor binding of pancreatic spasmolytic polypeptide (PSP) in rat intestinal mucosal cell membranes inhibits the adenylate cyclase activity , 1986, Regulatory Peptides.

[58]  Thomas A. Kunkel,et al.  Rapid and efficient site-specific mutagenesis without phenotypic selection. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[59]  P. Chambon,et al.  Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. , 1982, Nucleic acids research.