Tumor resistance in rats immunized to fetal tissues.

Abstract Inbred Fischer 344/N rats were immunized with irradiated cells of either a MCA-induced syngeneic fibrosarcoma (MCA-R), syngeneic second trimester fetal tissue, or allogeneic, Marshall 520 splenic lymphocytes. Animals injected intradermally with soluble antigen extracts (SAE) of MCA-R and normal Fischer 344/N tissues were evaluated for development of delayed cutaneous hypersensitivity reactions (DCHR). Fischer rats immune to allogeneic tissue gave no positive DCHR to either SAE. Ten of 11 rats immune to MCA-R and 6 of 9 immune to second trimester fetal tissue gave positive reactions to MCA-R SAE but none to normal tissue SAE. In a second experiment immunized rats were challenged subcutaneously with viable MCA-R tumor cells. Significant resistance to tumor growth was demonstrated by animals immune to MCA-R and by animals immune to second trimester fetal tissue. This resistance was unrelated to sex. Immunological similarity between fetal antigens and tumor associated transplantation antigens is suggested.

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