Controlled release of curcumin from thiolated starch-coated iron oxide magnetic nanoparticles: An in vitro evaluation

ABSTRACT Thiolated starch-coated iron oxide nanoparticles containing curcumin were developed to investigate their cytotoxicity on lymphocytes and cancer cell lines. These nanoparticles were prepared using different concentrations of thiolated starch to study the effect of polymer coating on various properties of nanoparticles, namely, yield percentage, particle size, drug encapsulation, etc. Zeta potential confirmed the stability of nanoparticles. The nanoparticles with 5% polymer coating showed drug encapsulation efficiency up to 78%, while loading efficiency was higher than 80%. The cytotoxicity assay revealed excellent compatibility of the system with lymphocyte cells while considerable amount of cytotoxicity on cancer cell lines. GRAPHICAL ABSTRACT

[1]  H. Sharma,et al.  Carboxymethyl starch-chitosan-coated iron oxide magnetic nanoparticles for controlled delivery of isoniazid , 2015, Journal of microencapsulation.

[2]  E. Cevher,et al.  Effect of Thiolated Polymers to Textural and Mucoadhesive Properties of Vaginal Gel Formulations Prepared with Polycarbophil and Chitosan , 2008, AAPS PharmSciTech.

[3]  K. Nguyen,et al.  Effects of surfactants on properties of polymer-coated magnetic nanoparticles for drug delivery application , 2011 .

[4]  A. Alizadeh,et al.  Nanotechnology-Applied Curcumin for Different Diseases Therapy , 2014, BioMed research international.

[5]  M. Alonso,et al.  Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines , 1997, Pharmaceutical Research.

[6]  Gareth J.S. Jenkins,et al.  Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) , 2010, Nano reviews.

[7]  Ihab M. Obaidat,et al.  Magnetic Nanoparticles: Surface Effects and Properties Related to Biomedicine Applications , 2013, International journal of molecular sciences.

[8]  P. Artursson,et al.  Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement , 1997, Pharmaceutical Research.

[9]  E. Syková,et al.  Poly(N,N-dimethylacrylamide)-coated maghemite nanoparticles for stem cell labeling. , 2009, Bioconjugate chemistry.

[10]  K. Chennazhi,et al.  Curcumin-Loaded N,O-Carboxymethyl Chitosan Nanoparticles for Cancer Drug Delivery , 2012, Journal of biomaterials science. Polymer edition.

[11]  Aqueous route for the synthesis of magnetite nanoparticles under atmospheric air: functionalization of surface with fluorescence marker , 2012 .

[12]  K. Prabhakar,et al.  Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer , 2011, International journal of pharmaceutical investigation.

[13]  H. Hofmann,et al.  Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system , 2005 .

[14]  Robert A Newman,et al.  Bioavailability of curcumin: problems and promises. , 2007, Molecular pharmaceutics.

[15]  In-Kyu Park,et al.  Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer , 2013, International journal of molecular sciences.

[16]  I. Otsuka,et al.  Elaboration of chitosan-coated nanoparticles loaded with curcumin for mucoadhesive applications. , 2012, Journal of colloid and interface science.

[17]  B. Aggarwal,et al.  Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. , 2007, Carcinogenesis.

[18]  B. Aggarwal,et al.  Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. , 2008, Biochemical pharmacology.

[19]  Ajay Kumar Gupta,et al.  Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. , 2005, Biomaterials.

[20]  Patrick Couvreur,et al.  Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. , 2012, Chemical reviews.

[21]  H. Sharma,et al.  Crosslinked thiolated starch coated Fe3O4 magnetic nanoparticles: Effect of montmorillonite and crosslinking density on drug delivery properties , 2014 .

[22]  Teruo Okano,et al.  Polymeric micelles as new drug carriers , 1996 .

[23]  O. Karaagac,et al.  A Simple Way to Synthesize Superparamagnetic Iron Oxide Nanoparticles in Air Atmosphere: Iron Ion Concentration Effect , 2010, IEEE Transactions on Magnetics.

[24]  N. Devi,et al.  Microencapsulation of isoniazid in genipin-crosslinked gelatin-A–κ-carrageenan polyelectrolyte complex , 2009, Drug Development and Industrial Pharmacy.