Effect of Anxiolytics on Cognitive Flexibility in Problem Solving

Objective:Our purpose is to examine the effect of different classes of anxiolytics on cognitive flexibility. Background:Situational stressors and anxiety impede performance on “creativity” tests requiring cognitive flexibility. Noradrenergic agents have been shown to modulate cognitive flexibility as assessed by performance on anagrams. To determine whether these findings on noradrenergic modulation of cognitive flexibility are specific to the noradrenergic system or are a nonspecific anxiety effect, we compared the effects of propranolol, lorazepam, and placebo on the anagram task. Methods:Subjects attended 3 test sessions. Prior to each session, subjects were given 1 of the 3 drugs. As in previous research, the natural log of the solution latency of each test item was summed for each test session and compared across drug conditions. Results:For subjects able to solve the anagrams, solution times after propranolol, but not lorazepam, were significantly lower than after placebo. Conclusions:Therefore, this suggests that the phenomenon of noradrenergic modulation of cognitive flexibility does not result from a nonspecific anxiolytic effect, but rather is specific to the noradrenergic system.

[1]  R. Cattell.  Theory of fluid and crystallized intelligence: A critical experiment. , 1963 .

[2]  B. W. Harleston,et al.  TEST-ANXIETY LEVEL, HEART RATE, AND ANAGRAM PROBLEM SOLVING. , 1965, Journal of personality and social psychology.

[3]  Jerry Tomasini.  Effect of Peer-Induced Anxiety on a Problem-Solving Task , 1973, Psychological reports.

[4]  Anagram Performance following Initial Exposure to Insoluble Anagrams , 1973 .

[5]  C. Martindale,et al.  The differential effect of increased arousal on creative and intellectual performance. , 1973, The Journal of genetic psychology.

[6]  S. Nader.  Letter: Storage and transport of serum for prolactin radioimmunoassay. , 1974, Lancet.

[7]  Relationship of Anagram Solving to Measures of Divergent-Production and Letter-Rearrangement Ability , 1975 .

[8]  M. Dey.  Anagram solution speed as a joint function of manifest anxiety and number of category sets. , 1978, The American journal of psychology.

[9]  D. Redmond,et al.  CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS , 1978, The Lancet.

[10]  Discriminant and Concurrent Validity of Two Commonly Used Measures of Test Anxiety , 1982 .

[11]  D. Charney,et al.  Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy. , 1982, Archives of general psychiatry.

[12]  Margaret A. Chesney,et al.  Epinephrine and Norepinephrine Responses in Continuously Collected Human Plasma to a Series of Stressors , 1983, Psychosomatic medicine.

[13]  D. Jasinski,et al.  Clonidine in morphine withdrawal. Differential effects on signs and symptoms. , 1985, Archives of general psychiatry.

[14]  J. Bemporad,et al.  Brief report: Open trial effects of beta-blockers on speech and social behaviors in 8 autistic adults , 1987, Journal of autism and developmental disorders.

[15]  M. Lader.  Beta-adrenoceptor antagonists in neuropsychiatry: an update. , 1988, The Journal of clinical psychiatry.

[16]  M. Conway,et al.  Individual differences in nonconscious processing: The role of creativity , 1990 .

[17]  Médications bêta-bloquantes et anxiété. Un intérêt thérapeutique certain. , 1991 .

[18]  J. Boulenger,et al.  [Beta-blocking drugs and anxiety. A proven therapeutic value]. , 1991, L'Encephale.

[19]  V. K. Jensen,et al.  "The effect of beta blockade on stress-induced cognitive dysfunction in adolescents". , 1991, Clinical pediatrics.

[20]  B. Leventhal,et al.  Clonidine Treatment of Hyperactive and Impulsive Children with Autistic Disorder , 1992, Journal of clinical psychopharmacology.

[21]  R. Tannock,et al.  Methylphenidate and cognitive perseveration in hyperactive children. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[22]  A. Yates,et al.  A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. , 1992, The Journal of clinical psychiatry.

[23]  J. Williams,et al.  Sensitization of locus ceruleus neurons during withdrawal from chronic stimulants and antidepressants. , 1992, The Journal of pharmacology and experimental therapeutics.

[24]  Cognitive effects of β‐adrenergic antagonists after single doses: Pharmacokinetics and pharmacodynamics of propranolol, atenolol, lorazepam, and placebo , 1993, Clinical pharmacology and therapeutics.

[25]  David L. Strayer,et al.  Executive function abilities in autism and Tourette syndrome: an information processing approach. , 1994, Journal of child psychology and psychiatry, and allied disciplines.

[26]  Use of clonidine for behavioral control in an adult patient with autism. , 1994, The American journal of psychiatry.

[27]  E. Sherman,et al.  Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity disorder? , 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

[28]  R Tannock,et al.  Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children , 1995, Journal of abnormal child psychology.

[29]  Lynette J. Tippett,et al.  Effects of focal brain lesions on visual problem-solving , 1996, Neuropsychologia.

[30]  M. Spitzer,et al.  Dopaminergic modulation of semantic network activation , 1996, Neuropsychologia.

[31]  M. Hasselmo,et al.  Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio. , 1997, Journal of neurophysiology.

[32]  D. Goldstein,et al.  Stressor specificity of peripheral catecholaminergic activation. , 1998, Advances in pharmacology.

[33]  K M Heilman,et al.  Noradrenergic modulation of cognitive flexibility in problem solving. , 1999, Neuroreport.

[34]  J. Cohen,et al.  The role of locus coeruleus in the regulation of cognitive performance. , 1999, Science.

[35]  David Q. Beversdorf,et al.  Central β-adrenergic modulation of cognitive flexibility , 2002 .

[36]  M. Nader,et al.  Chronic Cocaine Self-Administration Upregulates the Norepinephrine Transporter and Alters Functional Activity in the Bed Nucleus of the Stria Terminalis of the Rhesus Monkey , 2003, The Journal of Neuroscience.