Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study.

Replacement of invasive monitoring of cerebral venous oxygenation with noninvasive techniques offers great promise in the management of life-threatening neurologic illnesses including traumatic brain injury. We developed and built an optoacoustic system to noninvasively monitor cerebral venous oxygenation; the system includes a nanosecond Nd:YAG laser and a specially designed optoacoustic probe. We tested the system in vitro in sheep blood with experimentally varied oxygenation. Our results demonstrated that (1) the amplitude and temporal profile of the optoacoustic waves increase with blood oxygenation in the range from 24% to 92%, (2) optoacoustic signals can be detected despite optical and acoustic attenuation by thick bone, and (3) the system is capable of real-time and continuous measurements. These results suggest that the optoacoustic technique is technically feasible for continuous, noninvasive monitoring of cerebral venous oxygenation.

[1]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[2]  D. Prough,et al.  Validation in Volunteers of a Near-Infrared Spectroscope for Monitoring Brain Oxygenation In Vivo , 1996, Anesthesia and analgesia.

[3]  V S Letokhov,et al.  Studies of acoustical and shock waves in the pulsed laser ablation of biotissue , 1993, Lasers in surgery and medicine.

[4]  S Nioka,et al.  Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[6]  Kirill V. Larin,et al.  Monitoring of temperature distribution in tissues with optoacoustic technique in real time , 2000, BiOS.

[7]  W. Dunn.  Principles and Practice of Intensive Care Monitoring , 1998 .

[8]  Frank K. Tittel,et al.  Laser-based optoacoustic imaging in biological tissues , 1994, SPIE LASE.

[9]  R. Bullock,et al.  Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. , 1997, Neurosurgery.

[10]  Kirill V. Larin,et al.  Optoacoustic Technique for Non-invasive Continuous Monitoring of Blood Oxygenation , 2000 .

[11]  D. Delpy,et al.  Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. , 1988, Biochimica et biophysica acta.

[12]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring during thermotherapy , 2000, BiOS.

[13]  W. White,et al.  Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass. , 1994, The Annals of thoracic surgery.

[14]  D. Prough,et al.  The Influence of Carbon Dioxide and Body Position on Near-Infrared Spectroscopic Assessment of Cerebral Hemoglobin Oxygen Saturation , 1996, Anesthesia and analgesia.

[15]  Frank K. Tittel,et al.  Axial resolution of laser opto-acoustic imaging: influence of acoustic attenuation and diffraction , 1998, Photonics West - Biomedical Optics.

[16]  James G. Fujimoto,et al.  Advances in Optical Imaging and Photon Migration , 1996 .

[17]  B. Hooper.  Optical-thermal response of laser-irradiated tissue , 1996 .

[18]  R G Grossman,et al.  Jugular venous desaturation and outcome after head injury. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[19]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .