Treatment of infantile subglottic hemangioma with oral propranolol

Infantile subglottic hemangioma (SH) can cause biphasic stridor, respiratory distress and even life‐threatening airway compromise. Treatment of SH in infants has traditionally been characterized as a challenging situation with multiple therapeutic options without consensus as to which one is the best and with risks of severe side‐effects. Four infants with SH were treated with propranolol. Treatment with oral propranolol resulted in resolution of symptoms within 2 days, followed by complete recovery. Propranolol appears to be an effective treatment for SH and should be used as a first‐line treatment for SH when intervention is required.

[1]  K. Holland,et al.  Initiation and Use of Propranolol for Infantile Hemangioma: Report of a Consensus Conference , 2013, Pediatrics.

[2]  T. Russo,et al.  Hypervirulent K. Pneumoniae Secretes More and More Active Iron-Acquisition Molecules than “Classical” K. Pneumoniae Thereby Enhancing its Virulence , 2011, PloS one.

[3]  I. Bruce,et al.  Failure of propranolol in the treatment of childhood haemangiomas of the head and neck , 2011, The Journal of Laryngology & Otology.

[4]  S. Magina,et al.  Efficacy and safety of propranolol in the treatment of parotid hemangioma , 2011, Cutaneous and ocular toxicology.

[5]  C. Gorst,et al.  Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas. , 2011, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[6]  Kay W Chang,et al.  Propranolol for the treatment of a life-threatening subglottic and mediastinal infantile hemangioma. , 2010, The Journal of pediatrics.

[7]  B. Hartley,et al.  Successful treatment of isolated subglottic haemangioma with propranolol alone. , 2009, International journal of pediatric otorhinolaryngology.

[8]  U. Dyamenahalli,et al.  Propranolol for airway hemangiomas: Case report of novel treatment , 2009, The Laryngoscope.

[9]  D. Lipsker,et al.  Propranolol for Severe Infantile Hemangiomas: Follow-Up Report , 2009, Pediatrics.

[10]  M. Callegan,et al.  Hypermucoviscosity as a virulence factor in experimental Klebsiella pneumoniae endophthalmitis. , 2008, Investigative ophthalmology & visual science.

[11]  S. Wann,et al.  Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  Anne W. Lucky,et al.  Growth Characteristics of Infantile Hemangiomas: Implications for Management , 2008, Pediatrics.

[13]  F. Boralevi,et al.  Propranolol for severe hemangiomas of infancy. , 2008, The New England journal of medicine.

[14]  W. Ko,et al.  Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[15]  F. Roblot.  Extended-spectrum cephalosporin compared to cefazolin for treatment of Klebsiella pneumoniae-caused liver abscess , 2004 .

[16]  D. Fisher,et al.  An 18 year clinical review of septic arthritis from tropical Australia , 1996, Epidemiology and Infection.

[17]  P. Alburger,et al.  Pyogenic arthritis in infants and children: a review of 95 cases , 1986, Pediatric infectious disease.

[18]  J. Nelson,et al.  Septic arthritis in infants and children: a review of 117 cases. , 1966, Pediatrics.