Chapter 6 – Acetaminophen

[1]  Mitchell R. McGill,et al.  Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  N. Kaplowitz,et al.  Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis , 2015, Hepatology.

[3]  S. Melnyk,et al.  The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. , 2015, Free radical biology & medicine.

[4]  Mitchell R. McGill,et al.  Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  Mitchell R. McGill,et al.  Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. , 2015, Toxicology and applied pharmacology.

[6]  L. Gamon,et al.  What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)? , 2015, Chemical research in toxicology.

[7]  C. Gabay,et al.  The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases. , 2015, Cytokine.

[8]  Mitchell R. McGill,et al.  Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells , 2015, Xenobiotica; the fate of foreign compounds in biological systems.

[9]  H. Jaeschke,et al.  Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury. , 2015, Toxicology and applied pharmacology.

[10]  A. Eisenthal,et al.  Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury , 2015, Cell Death and Disease.

[11]  Oliver M. Bernhardt,et al.  Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues* , 2015, Molecular & Cellular Proteomics.

[12]  Elizabeth M. Lancaster,et al.  Acetaminophen hepatotoxicity: an updated review , 2014, Archives of Toxicology.

[13]  William M. Lee,et al.  Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. , 2014, Toxicological sciences : an official journal of the Society of Toxicology.

[14]  William M. Lee,et al.  Serum mitochondrial biomarkers and damage‐associated molecular patterns are higher in acetaminophen overdose patients with poor outcome , 2014, Hepatology.

[15]  Mitchell R. McGill,et al.  Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. , 2014, Toxicology and applied pharmacology.

[16]  R. Roy,et al.  Absolute quantitation of NAPQI-modified rat serum albumin by LC-MS/MS: monitoring acetaminophen covalent binding in vivo. , 2014, Chemical research in toxicology.

[17]  H. Jaeschke,et al.  Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. , 2014, Journal of hepatology.

[18]  Victor R. Ambros,et al.  Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis , 2014, Proceedings of the National Academy of Sciences.

[19]  W. Ding,et al.  Autophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential Therapeutic Targets , 2014, BioMed research international.

[20]  J. Molkentin,et al.  Identifying the components of the elusive mitochondrial permeability transition pore , 2014, Proceedings of the National Academy of Sciences.

[21]  P. Licznerski,et al.  An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore , 2014, Proceedings of the National Academy of Sciences.

[22]  Mitchell R. McGill,et al.  Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients , 2014, Expert opinion on drug metabolism & toxicology.

[23]  R. Ben-Joseph,et al.  A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States , 2014, Expert review of clinical pharmacology.

[24]  D. Laskin,et al.  Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase , 2014, Chemical research in toxicology.

[25]  Cheng Zhang,et al.  Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice. , 2014, Toxicology letters.

[26]  R. Schwabe,et al.  High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. , 2014, Cell metabolism.

[27]  Mitchell R. McGill,et al.  Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. , 2014, Toxicology and applied pharmacology.

[28]  Mitchell R. McGill,et al.  Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice , 2013, Hepatology.

[29]  E. Cheng,et al.  Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice , 2013, eLife.

[30]  Hartmut Jaeschke,et al.  Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver☆ , 2013, Redox biology.

[31]  Alasdair J Gray,et al.  Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital , 2013, Hepatology.

[32]  Hartmut Jaeschke,et al.  Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. , 2013, Toxicology and applied pharmacology.

[33]  Mitchell R. McGill,et al.  Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis , 2013, Pharmaceutical Research.

[34]  A. Jaeschke,et al.  Critical Role for Mixed-Lineage Kinase 3 in Acetaminophen-Induced Hepatotoxicity , 2012, Molecular Pharmacology.

[35]  Hartmut Jaeschke,et al.  Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. , 2012, Toxicology and applied pharmacology.

[36]  P. Kubes,et al.  Sterile inflammation in the liver. , 2012, Gastroenterology.

[37]  I. Sketris,et al.  Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study , 2012, BMC clinical pharmacology.

[38]  Mitchell R. McGill,et al.  Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[39]  Mitchell R. McGill,et al.  Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. , 2012, Journal of hepatology.

[40]  Hartmut Jaeschke,et al.  The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. , 2012, The Journal of clinical investigation.

[41]  L. MacMillan-Crow,et al.  Acetaminophen-Induced Hepatotoxicity and Protein Nitration in Neuronal Nitric-Oxide Synthase Knockout Mice , 2012, Journal of Pharmacology and Experimental Therapeutics.

[42]  Hartmut Jaeschke,et al.  Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[43]  H. Jaeschke,et al.  Activation of autophagy protects against acetaminophen‐induced hepatotoxicity , 2012, Hepatology.

[44]  Jonathan Moggs,et al.  Circulating microRNAs as potential markers of human drug‐induced liver injury , 2011, Hepatology.

[45]  U. Boelsterli,et al.  Acetaminophen overdose‐induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D‐regulated permeability transition , 2011, Hepatology.

[46]  N. Kaplowitz,et al.  c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice* , 2011, The Journal of Biological Chemistry.

[47]  H. Jaeschke,et al.  Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[48]  Dominic P. Williams,et al.  Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. , 2011, Toxicology and applied pharmacology.

[49]  L. MacMillan-Crow,et al.  Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase , 2011, Journal of Pharmacology and Experimental Therapeutics.

[50]  H. Jaeschke,et al.  The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. , 2011, Toxicology and applied pharmacology.

[51]  K. Heard,et al.  Acetaminophen-cysteine adducts during therapeutic dosing and following overdose , 2011, BMC gastroenterology.

[52]  Hartmut Jaeschke,et al.  HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity , 2011, Hepatology.

[53]  H. Jaeschke,et al.  No evidence for caspase‐dependent apoptosis in acetaminophen hepatotoxicity , 2011, Hepatology.

[54]  H. Jaeschke,et al.  Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury , 2011, Free radical research.

[55]  H. Jaeschke,et al.  Acetaminophen‐induced hepatic neutrophil accumulation and inflammatory liver injury in CD18‐deficient mice , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[56]  H. Jaeschke,et al.  The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[57]  P. Vandenabeele,et al.  Molecular mechanisms of necroptosis: an ordered cellular explosion , 2010, Nature Reviews Molecular Cell Biology.

[58]  H. Jaeschke,et al.  Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. , 2010, Toxicology and applied pharmacology.

[59]  H. Jaeschke,et al.  Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[60]  C. Giulivi,et al.  Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease. , 2010, Free radical biology & medicine.

[61]  H. Jaeschke,et al.  c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. , 2010, Toxicology and applied pharmacology.

[62]  B. Zhivotovsky,et al.  Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). , 2010, Biochemical and biophysical research communications.

[63]  T. Vanden Berghe,et al.  The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis , 2010, Science Signaling.

[64]  Michael P Holt,et al.  The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. , 2010, Toxicology letters.

[65]  C. Zwingmann,et al.  Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N‐acetylcysteine , 2010, Hepatology.

[66]  Dominic P. Williams,et al.  High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[67]  Na Zhang,et al.  RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis , 2009, Science.

[68]  R. T. Miller,et al.  Absence of Nitric-oxide Synthase in Sequentially Purified Rat Liver Mitochondria* , 2009, The Journal of Biological Chemistry.

[69]  S. Manabe,et al.  Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen , 2009, Toxicologic pathology.

[70]  Michael P Holt,et al.  Identification and characterization of infiltrating macrophages in acetaminophen‐induced liver injury , 2008, Journal of leukocyte biology.

[71]  William M. Lee.  Acetaminophen‐related acute liver failure in the United States , 2008, Hepatology research : the official journal of the Japan Society of Hepatology.

[72]  M. Karin,et al.  Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. , 2008, Gastroenterology.

[73]  Neil Kaplowitz,et al.  Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury* , 2008, Journal of Biological Chemistry.

[74]  H. Jaeschke,et al.  Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase. , 2008, Toxicology letters.

[75]  W. Waring,et al.  Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[76]  H. Jaeschke,et al.  Mitochondrial Bax Translocation Accelerates DNA Fragmentation and Cell Necrosis in a Murine Model of Acetaminophen Hepatotoxicity , 2008, Journal of Pharmacology and Experimental Therapeutics.

[77]  S. Krantic,et al.  AIF-Mediated Programmed Necrosis: A Highly Orchestrated Way to Die , 2007, Cell cycle.

[78]  H. Mannherz,et al.  Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice , 2007, Histochemistry and Cell Biology.

[79]  H. Forman,et al.  ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages* , 2007, Journal of Biological Chemistry.

[80]  H. Jaeschke,et al.  Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[81]  H. Jaeschke,et al.  Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. , 2006, Toxicology and applied pharmacology.

[82]  H. Jaeschke,et al.  Role of caspases in acetaminophen-induced liver injury. , 2006, Life sciences.

[83]  William M. Lee,et al.  Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. , 2006, Gastroenterology.

[84]  William M. Lee,et al.  Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study , 2005, Hepatology.

[85]  H. Jaeschke,et al.  Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity , 2005, Journal of Pharmacology and Experimental Therapeutics.

[86]  W. Garrard,et al.  Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G , 2005, Journal of cellular biochemistry.

[87]  Jeffrey Robbins,et al.  Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death , 2005, Nature.

[88]  R. Kurten,et al.  Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes , 2005, Journal of Pharmacology and Experimental Therapeutics.

[89]  H. Jaeschke,et al.  Mitochondrial permeability transition in acetaminophen‐induced necrosis and apoptosis of cultured mouse hepatocytes , 2004, Hepatology.

[90]  Hartmut Jaeschke,et al.  Apoptosis and necrosis in liver disease , 2004, Liver international : official journal of the International Association for the Study of the Liver.

[91]  H. Jaeschke,et al.  The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. , 2003, Toxicology letters.

[92]  L. James,et al.  Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[93]  H. Jaeschke,et al.  Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice , 2003, Journal of Pharmacology and Experimental Therapeutics.

[94]  H. Jaeschke,et al.  Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. , 2003, Gastroenterology.

[95]  M. Crabtree,et al.  Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases. , 2003, Toxicology and applied pharmacology.

[96]  W. Abebe,et al.  Herbal medication: potential for adverse interactions with analgesic drugs , 2002, Journal of clinical pharmacy and therapeutics.

[97]  J. Brady,et al.  Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. , 2002, Chemical research in toxicology.

[98]  H. Jaeschke,et al.  Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione , 2002, Journal of Pharmacology and Experimental Therapeutics.

[99]  Steven D. Cohen,et al.  Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. , 2002, Toxicology and Applied Pharmacology.

[100]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[101]  H. Jaeschke,et al.  Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion. , 2002, Toxicology and applied pharmacology.

[102]  H. Jaeschke,et al.  Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[103]  R. Edwards,et al.  Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[104]  J. Hinson,et al.  Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[105]  Paul S. Brookes,et al.  Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[106]  M. N. Álvarez,et al.  Unraveling peroxynitrite formation in biological systems. , 2001, Free radical biology & medicine.

[107]  A. Farhood,et al.  The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[108]  H. Jaeschke,et al.  Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice. , 1999, Toxicology and applied pharmacology.

[109]  A. Burlingame,et al.  Identification of the Hepatic Protein Targets of Reactive Metabolites of Acetaminophen in Vivo in Mice Using Two-dimensional Gel Electrophoresis and Mass Spectrometry* , 1998, The Journal of Biological Chemistry.

[110]  N. Pumford,et al.  Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. , 1998, Chemical research in toxicology.

[111]  Steven D. Cohen,et al.  Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin‐α gene knockout mice , 1998, Hepatology.

[112]  K. Jungermann,et al.  Modulation by oxygen of zonal gene expression in liver studied in primary rat hepatocyte cultures , 1997, Cell Biology and Toxicology.

[113]  Steven D. Cohen,et al.  Selective protein covalent binding and target organ toxicity. , 1997, Toxicology and applied pharmacology.

[114]  N. Pumford,et al.  Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein. , 1997, Toxicology letters.

[115]  M. Zoratti,et al.  The mitochondrial permeability transition. , 1995, Biochimica et biophysica acta.

[116]  Steven D. Cohen,et al.  A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide. , 1995, Chemical research in toxicology.

[117]  S. Nelson.  Molecular Mechanisms of the Hepatotoxicity Caused by Acetaminophen , 1990, Seminars in liver disease.

[118]  Steven D. Cohen,et al.  Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice. , 1988, Toxicology and applied pharmacology.

[119]  A. Proudfoot,et al.  TREATMENT OF PARACETAMOL (ACETAMINOPHEN) POISONING WITH N-ACETYLCYSTEINE , 1977, The Lancet.

[120]  M. Maes,et al.  Experimental models of hepatotoxicity related to acute liver failure. , 2016, Toxicology and applied pharmacology.

[121]  G. Groothuis,et al.  AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver , 2012, Archives of Toxicology.

[122]  Toshiharu Horie,et al.  Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. , 2005, Journal of hepatology.