Mammalian beta-glucuronidase: genetics, molecular biology, and cell biology.

Publisher Summary β -Glucuronidase is also a very ancient protein, and its early evolutionary origin is evidenced by the appreciable sequence identity between the Escherichia coli and mammalian enzymes. β-glucuronidase has become a model system for the study of genetic regulatory polymorphism, mechanisms of androgen induction, lysosomal enzyme processing, and mechanisms of intracellular enzyme localization. As a result, it is now one of the best understood mammalian proteins from the combined standpoint of genetics, molecular biology, cell biology, and regulation. Some of the genetic resources created in the course of this work have provided experimental tools useful in other areas of research as diverse as cell lineage studies in mammalian development and the evolution of genetic regulatory mechanisms. These describe the substrate specificities of the enzyme, its distribution in nature, and its relation to several human diseases; androgen induction of the enzyme in kidney; intracellular localization mechanisms genetic regulation; and clinical aspects of human enzyme deficiency.

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