Novel molecular targets for the treatment of obesity
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C. Strader | E. Parker | J. Hwa | M. V. Heek
[1] M. Bayne,et al. Cloning and Expressional Characterization of a Novel Galanin Receptor , 1997, The Journal of Biological Chemistry.
[2] R. L. Dow. β3-adrenergic agonists: potential therapeutics for obesity , 1997 .
[3] R. Cone,et al. Independent and additive effects of central POMC and leptin pathways on murine obesity. , 1997, Science.
[4] R. Seeley,et al. Melanocortin receptors in leptin effects , 1997, Nature.
[5] P. Hipskind,et al. Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists. , 1997, Journal of medicinal chemistry.
[6] S. Whitebread,et al. Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides , 1997, Diabetes.
[7] D. Romsos,et al. Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice. , 1997, The Journal of nutrition.
[8] R. Unger,et al. Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity. , 1997, The Journal of clinical investigation.
[9] A. Sleight,et al. Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder. , 1997, Journal of medicinal chemistry.
[10] A. Blomqvist,et al. Y-receptor subtypes—how many more? , 1997, Trends in Neurosciences.
[11] S. O’Rahilly,et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.
[12] C. Newgard,et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[13] B. Lowell,et al. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. , 1997, Biochemical and biophysical research communications.
[14] J. Wong,et al. Obesity, Diabetes and Functions for Proopiomelanocortin-derived Peptides , 1997, Molecular and Cellular Endocrinology.
[15] L. V. D. van der Ploeg,et al. Molecular cloning and characterization of a new receptor for galanin , 1997, FEBS letters.
[16] Christophe Fleury,et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia , 1997, Nature Genetics.
[17] G. Barsh,et al. Effects of recombinant agouti-signaling protein on melanocortin action. , 1997, Molecular endocrinology.
[18] C. Strader,et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. , 1997, The Journal of clinical investigation.
[19] R. Cone,et al. Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.
[20] W. Banks,et al. Leptin enters the brain by a saturable system independent of insulin , 1996, Peptides.
[21] R. Palmiter,et al. Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y , 1996, Science.
[22] T. Tanaka,et al. Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. , 1996, Endocrinology.
[23] R. Considine,et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance , 1996, The Lancet.
[24] S. Whitebread,et al. A receptor subtype involved in neuropeptide-Y-induced food intake , 1996, Nature.
[25] D. Porte,et al. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans , 1996, Nature Medicine.
[26] M. Phillips,et al. Leptin receptor missense mutation in the fatty Zucker rat , 1996, Nature Genetics.
[27] L. Tartaglia,et al. Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice , 1996, Cell.
[28] B. Lowell,et al. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action , 1995, Nature Medicine.
[29] E. Ravussin,et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects , 1995, Nature Medicine.
[30] J. Bue-Valleskey,et al. The role of neuropeptide Y in the antiobesity action of the obese gene product , 1995, Nature.
[31] J. Leban,et al. High-affinity neuropeptide Y receptor antagonists. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[32] F. Lönnqvist,et al. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects , 1995, Nature Medicine.
[33] M. Deitel,et al. Increased obese mRNA expression in omental fat cells from massively obese humans , 1995, Nature Medicine.
[34] M. Pelleymounter,et al. Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.
[35] R. Devos,et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.
[36] Steven L. Cohen,et al. Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.
[37] R. Considine,et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. , 1995, The Journal of clinical investigation.
[38] R. Quirion,et al. Apparent affinity and potency of BIBP3226, a non-peptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Y1, Y2 and Y3 receptors. , 1995, European journal of pharmacology.
[39] David Julius,et al. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors , 1995, Nature.
[40] F. Oury-Donat,et al. SR120819A, an orally‐active and selective neuropeptide Y Y1 receptor antagonist , 1995, FEBS letters.
[41] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.
[42] Y Watanabe,et al. Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[43] J. Mayaux,et al. Molecular cloning of a functional human galanin receptor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[44] M. G. Dube,et al. Evidence that neuropeptide Y is a physiological signal for normal food intake , 1994, Brain Research.
[45] D. Smith,et al. Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[46] S. Leibowitz,et al. Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion , 1992, Brain Research.
[47] S. Liggett. Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. , 1992, Molecular pharmacology.
[48] S. Leibowitz,et al. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect , 1992, Peptides.
[49] J. Cidlowski,et al. Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation. , 1991, Endocrinology.
[50] G. Fisone,et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[51] R. Jung,et al. Weight loss in obese subjects on a restricted diet given BRL 26830A, a new atypical β adrenoceptor agonist , 1988, British medical journal.
[52] S. Kalra,et al. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus , 1988, Peptides.
[53] M. Sennitt,et al. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs , 1984, Nature.
[54] Jon L. Wright. Design and discovery of neuropeptide Y1 receptor antagonists , 1997 .
[55] D. Smith,et al. Neuropeptide Y Induced Feeding in the Rat Is Mediated by a Novel Receptor1. , 1997, Endocrinology.
[56] C. Wahlestedt,et al. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion. , 1994, Brain research. Molecular brain research.