Cholesterol esters as growth regulators of lymphocytic leukaemia cells

Objective:  Alterations in plasma lipid profile and in intracellular cholesterol homoeostasis have been described in various malignancies; however, significance of these alterations, if any, in cancer biology is not clear. The aim of the present study was to investigate a possible correlation between alterations in cholesterol metabolism and expansion of leukaemia cell numbers.

[1]  A. Uittenbogaard,et al.  Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae. , 2013, The Journal of Biological Chemistry.

[2]  R. Stam,et al.  Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants. , 2010, Blood.

[3]  R. Gniadecki,et al.  Cholesterol and Lipid Rafts as Regulators of Signaling Through the EGFReceptor in Keratinocytes , 2009 .

[4]  K. Stuhlmeier,et al.  Liver X Receptors Interfere with Cytokine- Induced Proliferation and Cell Survival in Normal and Leukemic Lymphocytes , 2009 .

[5]  C. Enrich,et al.  Annexins--modulators of EGF receptor signalling and trafficking. , 2009, Cellular signalling.

[6]  L. Pike,et al.  Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding. , 2009, Biochemistry.

[7]  R. Landgraf,et al.  Signaling through ERBB receptors: multiple layers of diversity and control. , 2006, Cellular signalling.

[8]  S. Ye,et al.  Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. , 2006, The American journal of pathology.

[9]  J. Breslow,et al.  Intracellular Cholesterol Transport , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[10]  Rhoderick E. Brown,et al.  Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to Membrane Level Effects , 2003, Journal of Biological Chemistry.

[11]  D. Wallwiener,et al.  Statins can inhibit proliferation of human breast cancer cells in vitro. , 2003, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[12]  M. Resh,et al.  Cholesterol Depletion from the Plasma Membrane Triggers Ligand-independent Activation of the Epidermal Growth Factor Receptor* , 2002, The Journal of Biological Chemistry.

[13]  I. Madshus,et al.  Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae. , 2002, Journal of cell science.

[14]  C. Fielding,et al.  Cholesterol and caveolae: structural and functional relationships. , 2000, Biochimica et biophysica acta.

[15]  J. Gmiński,et al.  Serum HDL cholesterol concentration in patients with squamous cell and small cell lung cancer. , 2000, International journal of molecular medicine.

[16]  D. Mangelsdorf,et al.  Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. , 2000, Science.

[17]  P. Nowell,et al.  The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Engelman,et al.  p42/44 MAP Kinase-dependent and -independent Signaling Pathways Regulate Caveolin-1 Gene Expression , 1999, The Journal of Biological Chemistry.

[19]  Richard G. W. Anderson,et al.  Regulated Migration of Epidermal Growth Factor Receptor from Caveolae* , 1999, The Journal of Biological Chemistry.

[20]  R. Parton,et al.  Membrane microdomains and caveolae. , 1999, Current opinion in cell biology.

[21]  M. Maa,et al.  c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function* , 1999, The Journal of Biological Chemistry.

[22]  M. Hallek,et al.  Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survival , 1999, Journal of Molecular Medicine.

[23]  G. Gahrton,et al.  Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation. , 1998, The American journal of pathology.

[24]  Richard G. W. Anderson,et al.  Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)* , 1998, The Journal of Biological Chemistry.

[25]  E. Ikonen,et al.  Functional rafts in cell membranes , 1997, Nature.

[26]  L. Tessitore,et al.  Clinical remission is associated with restoration of normal high-density lipoprotein cholesterol levels in children with malignancies. , 1995, Clinical science.

[27]  R. Sutherland,et al.  Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[28]  L. Tessitore,et al.  Cholesterol content in tumor tissues is inversely associated with high‐density lipoprotein cholesterol in serum in patients with gastrointestinal cancer , 1994, Cancer.

[29]  P. Stacpoole,et al.  In vivo regulation of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma. , 1991, Journal of lipid research.

[30]  R. Clayman,et al.  Abnormal cholesterol metabolism in renal clear cell carcinoma. , 1987, Journal of lipid research.

[31]  R. Pittman,et al.  A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters. , 1987, The Journal of biological chemistry.

[32]  J. Oram,et al.  Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization. , 1987, The Journal of biological chemistry.

[33]  J. Albers,et al.  Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. , 1982, Clinical chemistry.

[34]  M. Brown,et al.  Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. , 1978, Blood.

[35]  M. Shinitzky,et al.  Cholesterol as a bioregulator in the development and inhibition of leukemia. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[36]  W. R. Bloor,et al.  LIPID CONTENT OF TUMORS. , 1932, The Journal of clinical investigation.

[37]  C. Cellai,et al.  Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.

[38]  A. Pani,et al.  CELL GROWTH AND CHOLESTEROL ESTERS , 2004 .

[39]  M. Freeman,et al.  Cholesterol and prostate cancer , 2004, Journal of cellular biochemistry.

[40]  Kelvin K. W. Chan,et al.  The statins as anticancer agents. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[41]  G. Ness,et al.  Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. , 2000, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[42]  A. Fadda,et al.  HDL subfractions as altered in cancer patients. , 1995, Journal of pharmaceutical and biomedical analysis.

[43]  S. Umeki,et al.  Decreases in serum cholesterol levels in advanced lung cancer. , 1993, Respiration; international review of thoracic diseases.

[44]  L. Tessitore,et al.  Altered pattern of lipid metabolism in patients with lung cancer. , 1992, Oncology.

[45]  A. Kandutsch,et al.  The role of cholesterol in malignancy. , 1978, Progress in experimental tumor research.

[46]  A. Roffo Heliotropism of Cholesterol in Relation to Skin Cancer , 1933 .