Acute lymphoblastic leukaemia

Acute lymphoblastic leukaemia (ALL) is a malignant transformation of a clone of cells from lymphoid progenitor cells. The majority of cases are of B-cell origin but it can also arise from T-cell precursors. Lymphoid precursors proliferate and replace the normal cells of the bone marrow and blasts spill into the peripheral circulation. It can be distinguished from other malignancies of lymphoid tissue by the immunophenotype of the cells. Cytochemistry and cytogenetic markers are also used to classify the malignant lymphoid clone.

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