Membrane Structural Biology: With Biochemical and Biophysical Foundations

Membrane Structural Biology brings together a physicochemical analysis of the membrane with the latest structural biology on membrane lipids and proteins to offer an exciting portrayal of biomembranes. Written with remarkable clarity, this text appears at a time when membranes have moved back into the scientific spotlight and will provide a unique foundation for advanced students and working scientists. The structure, function, and biogenesis of membrane lipids and proteins are examined, bioinformatics and computational approaches to membrane components are introduced, and the high-resolution structures that are giving new insights into the vital roles membranes play are discussed. The many correlations between membrane research and human health are discussed and key themes for future work in this area are identified. Membrane structural biology is poised to answer many basic and applied questions and this cutting-edge text will provide a solid grounding for all those working in this field.

[1]  Krzysztof Palczewski,et al.  The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. , 2003, Annual review of biophysics and biomolecular structure.

[2]  S. Iwata,et al.  Formate dehydrogenase--a versatile enzyme in changing environments. , 2003, Current opinion in structural biology.

[3]  Bong-Gyoon Han,et al.  Structural basis of water-specific transport through the AQP1 water channel , 2001, Nature.

[4]  So Iwata,et al.  Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. , 2004, Current opinion in structural biology.

[5]  A. Leslie,et al.  The rotary mechanism of ATP synthase. , 2000, Current Opinion in Structural Biology.

[6]  E. Pebay-Peyroula,et al.  Nucleotide exchange in mitochondria: insight at a molecular level. , 2004, Current opinion in structural biology.

[7]  K. Diederichs,et al.  Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism , 2006, Science.

[8]  R. Dalbey,et al.  Sec-translocase mediated membrane protein biogenesis. , 2004, Biochimica et biophysica acta.

[9]  Karl Edman,et al.  Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport. , 2002, Biochimica et biophysica acta.

[10]  D C Rees,et al.  Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. , 1998, Science.

[11]  J. Deisenhofer,et al.  Structures of bacterial photosynthetic reaction centers. , 1991, Annual review of cell biology.

[12]  Eduardo Perozo,et al.  Structure and mechanism in prokaryotic mechanosensitive channels. , 2003, Current opinion in structural biology.

[13]  A. Yamaguchi,et al.  Multidrug-exporting secondary transporters. , 2003, Current opinion in structural biology.

[14]  H. Nikaido,et al.  Porins and specific channels of bacterial outer membranes , 1992, Molecular microbiology.

[15]  A. Lee,et al.  Ca2+ -ATPase structure in the E1 and E2 conformations: mechanism, helix-helix and helix-lipid interactions. , 2002, Biochimica et biophysica acta.

[16]  D. Oesterhelt,et al.  Functions of a new photoreceptor membrane. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[17]  R. Dawson,et al.  Structure of a bacterial multidrug ABC transporter , 2006, Nature.

[18]  S. Ferguson-Miller,et al.  Energy transduction: proton transfer through the respiratory complexes. , 2006, Annual review of biochemistry.

[19]  D. Engelman Membranes are more mosaic than fluid , 2005, Nature.

[20]  D. Oesterhelt,et al.  Closing in on bacteriorhodopsin: progress in understanding the molecule. , 1999, Annual review of biophysics and biomolecular structure.

[21]  Klaus Schulten,et al.  Molecular dynamics simulations of proteins in lipid bilayers. , 2005, Current opinion in structural biology.

[22]  Michael Edidin,et al.  Lipids on the frontier: a century of cell-membrane bilayers , 2003, Nature Reviews Molecular Cell Biology.

[23]  A. Lee,et al.  Lipid-protein interactions in biological membranes: a structural perspective. , 2003, Biochimica et biophysica acta.

[24]  A G Leslie,et al.  Molecular architecture of the rotary motor in ATP synthase. , 1999, Science.

[25]  J. Bowie,et al.  Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure. , 2002, Journal of molecular biology.

[26]  R. MacKinnon Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). , 2004 .

[27]  G. von Heijne,et al.  Biogenesis of inner membrane proteins in Escherichia coli. , 2005, Annual review of microbiology.

[28]  S. Iwata,et al.  Structure and Mechanism of the Lactose Permease of Escherichia coli , 2003, Science.

[29]  Hiroyasu Itoh,et al.  Rotation of F1-ATPase: how an ATP-driven molecular machine may work. , 2004, Annual review of biophysics and biomolecular structure.

[30]  Benoît Roux,et al.  Ion conduction and selectivity in K(+) channels. , 2005, Annual review of biophysics and biomolecular structure.

[31]  S. Iwata,et al.  The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides. , 2002, Journal of molecular biology.

[32]  Benoît Roux,et al.  Biological membranes : a molecular perspective from computation and experiment , 1996 .

[33]  P. Booth,et al.  Membrane protein folding. , 1999, Current opinion in structural biology.

[34]  G. von Heijne,et al.  Materials and Methods Figs. S1 to S3 References and Notes Global Topology Analysis of the Escherichia Coli Inner Membrane Proteome , 2022 .

[35]  E. Ikonen,et al.  Functional rafts in cell membranes , 1997, Nature.

[36]  V. Lingappa,et al.  Integral membrane protein biosynthesis: why topology is hard to predict. , 2002, Journal of cell science.

[37]  F. Hartl,et al.  The binding cascade of SecB to SecA to SecY E mediates preprotein targeting to the E. coli plasma membrane , 1990, Cell.

[38]  M H Saier,et al.  The complete phosphotransferase system in Escherichia coli. , 2001, Journal of molecular microbiology and biotechnology.

[39]  K. Sandvig,et al.  Penetration of protein toxins into cells. , 2000, Current opinion in cell biology.

[40]  David P. Chimento,et al.  Substrate-induced transmembrane signaling in the cobalamin transporter BtuB , 2003, Nature Structural Biology.

[41]  Kazuhiko Kinosita,et al.  Direct observation of the rotation of F1-ATPase , 1997, Nature.

[42]  G. Carman,et al.  Lipid Signaling Enzymes and Surface Dilution Kinetics (*) , 1995, The Journal of Biological Chemistry.

[43]  Tilman Schirmer General and specific porins from bacterial outer membranes. , 1998, Journal of structural biology.

[44]  J. Lanyi X-ray diffraction of bacteriorhodopsin photocycle intermediates (Review) , 2004 .

[45]  J Koepke,et al.  Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. , 2000, Structure.

[46]  Sergei Sukharev,et al.  Mechanosensitive channels: what can we learn from ‘simple’ model systems? , 2004, Trends in Neurosciences.

[47]  D. Chapman Phase transitions and fluidity characteristics of lipids and cell membranes , 1975, Quarterly Reviews of Biophysics.

[48]  R. Dutzler,et al.  Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. , 1996, Structure.

[49]  J. Rosenbusch,et al.  Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution , 1995, Science.

[50]  J Frank,et al.  Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. , 1997, Science.

[51]  S. Sligar,et al.  Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size. , 2004, Journal of the American Chemical Society.

[52]  J. Nagle,et al.  Lipid bilayers: thermodynamics, structure, fluctuations, and interactions. , 2004, Chemistry and physics of lipids.

[53]  Yoshinori Fujiyoshi,et al.  [Structure and function of water channels]. , 2002, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[54]  N. Pfanner,et al.  Mitochondrial protein import: two membranes, three translocases. , 2002, Current opinion in cell biology.

[55]  J. Rosenbusch,et al.  Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Garavito,et al.  Detergents as Tools in Membrane Biochemistry* , 2001, The Journal of Biological Chemistry.

[57]  H. Luecke,et al.  X-ray crystallographic analysis of lipid-protein interactions in the bacteriorhodopsin purple membrane. , 2003, Annual review of biophysics and biomolecular structure.

[58]  B. Pitard,et al.  Reconstitution of membrane proteins into liposomes: application to energy-transducing membrane proteins. , 1995, Biochimica et biophysica acta.

[59]  D. Chapman,et al.  Micelles, Monolayers, and Biomembranes , 1994 .

[60]  D. Marsh,et al.  Structure, dynamics and composition of the lipid-protein interface. Perspectives from spin-labelling. , 1998, Biochimica et biophysica acta.

[61]  C. Toyoshima Ion pumping by calcium ATPase of sarcoplasmic reticulum. , 2007, Advances in experimental medicine and biology.

[62]  V. Müller,et al.  Structure-function relationships of A-, F- and V-ATPases. , 2001, The Journal of experimental biology.

[63]  A. Aderem,et al.  The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. , 1995, Trends in biochemical sciences.

[64]  Lan Guan,et al.  Lessons from lactose permease. , 2006, Annual review of biophysics and biomolecular structure.

[65]  R. MacKinnon,et al.  Principles of Selective Ion Transport in Channels and Pumps , 2005, Science.

[66]  A. Helenius,et al.  Solubilization of membranes by detergents. , 1975, Biochimica et biophysica acta.

[67]  C. Tate Comparison of three structures of the multidrug transporter EmrE. , 2006, Current opinion in structural biology.

[68]  H. Mcconnell,et al.  Condensed complexes of cholesterol and phospholipids. , 2003, Biophysical journal.

[69]  G. Rummel,et al.  Crystal structures explain functional properties of two E. coli porins , 1992, Nature.

[70]  K. Palczewski,et al.  Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.

[71]  E. Pebay-Peyroula,et al.  X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases. , 1997, Science.

[72]  P. Boyer,et al.  Energy, Life, and ATP (Nobel Lecture). , 1998, Angewandte Chemie.

[73]  J. Bockaert,et al.  Molecular tinkering of G protein‐coupled receptors: an evolutionary success , 1999, The EMBO journal.

[74]  M. Vrljic,et al.  Liquid-liquid immiscibility in membranes. , 2003, Annual review of biophysics and biomolecular structure.

[75]  Robert M Stroud,et al.  Glycerol facilitator GlpF and the associated aquaporin family of channels. , 2003, Current opinion in structural biology.

[76]  G. Feigenson,et al.  Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: nanoscopic domain formation driven by cholesterol. , 2001, Biophysical journal.

[77]  Hiromi Nomura,et al.  Structural changes in the calcium pump accompanying the dissociation of calcium , 2002, Nature.

[78]  J. Deisenhofer,et al.  Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution , 1985, Nature.

[79]  D. Rees,et al.  The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[80]  Satoshi Murakami,et al.  Crystal structures of a multidrug transporter reveal a functionally rotating mechanism , 2006, Nature.

[81]  D. Marsh,et al.  The protein-lipid interface: perspectives from magnetic resonance and crystal structures. , 2004, Biochimica et biophysica acta.

[82]  Youxing Jiang,et al.  The open pore conformation of potassium channels , 2002, Nature.

[83]  H. Nury,et al.  Relations between structure and function of the mitochondrial ADP/ATP carrier. , 2006, Annual review of biochemistry.

[84]  Jue Chen,et al.  ATP-binding cassette transporters in bacteria. , 2004, Annual review of biochemistry.

[85]  K. H. Kalk,et al.  Structural evidence for dimerization-regulated activation of an integral membrane phospholipase. , 1999 .

[86]  Da-Neng Wang,et al.  Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli , 2003, Science.

[87]  Mahendra K. Jain,et al.  Long-range order in biomembranes. , 1977, Advances in lipid research.

[88]  D. Engelman,et al.  Sequence motifs, polar interactions and conformational changes in helical membrane proteins. , 2003, Current opinion in structural biology.

[89]  S. Yoshikawa,et al.  X-ray structure and the reaction mechanism of bovine heart cytochrome c oxidase. , 2000, Journal of inorganic biochemistry.

[90]  Mark Gerstein,et al.  Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions , 2004, Quarterly Reviews of Biophysics.

[91]  J. Slotte,et al.  Cholesterol interactions with phospholipids in membranes. , 2002, Progress in lipid research.

[92]  T. Endo,et al.  Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles , 2003, Journal of Cell Science.

[93]  S. Schuldiner,et al.  When biochemistry meets structural biology: the cautionary tale of EmrE. , 2007, Trends in biochemical sciences.

[94]  Colin Hughes,et al.  Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export , 2000, Nature.

[95]  K. Miki,et al.  Structural basis of bacterial photosynthetic reaction centers. , 2001, Journal of biochemistry.

[96]  Douglas C. Rees,et al.  The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism , 2002, Science.

[97]  H. Zgurskaya,et al.  Conformational flexibility in the multidrug efflux system protein AcrA. , 2006, Structure.

[98]  Gunnar von Heijne,et al.  Transmembrane helices before, during, and after insertion. , 2005, Current opinion in structural biology.

[99]  Eva Pebay-Peyroula,et al.  Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside , 2003, Nature.

[100]  S. White,et al.  Fluid bilayer structure determination by the combined use of x-ray and neutron diffraction. I. Fluid bilayer models and the limits of resolution. , 1991, Biophysical journal.

[101]  G. Blobel,et al.  A protein-conducting channel in the endoplasmic reticulum , 1991, Cell.

[102]  Florence Tama,et al.  Structure of the E. coli protein-conducting channel bound to a translating ribosome , 2005, Nature.

[103]  M. J. Lemieux,et al.  The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily. , 2004, Current opinion in structural biology.

[104]  Luc Moulinier,et al.  Transmembrane Signaling across the Ligand-Gated FhuA Receptor Crystal Structures of Free and Ferrichrome-Bound States Reveal Allosteric Changes , 1998, Cell.

[105]  M. Saier,et al.  The Transporter Classification (TC) System, 2002 , 2002, Critical reviews in biochemistry and molecular biology.

[106]  Hiroshi Nikaido,et al.  Multidrug resistance mechanisms: drug efflux across two membranes , 2000, Molecular microbiology.

[107]  S. Buchanan,et al.  Beta-barrel proteins from bacterial outer membranes: structure, function and refolding. , 1999, Current opinion in structural biology.

[108]  J. Nagle,et al.  Structure of lipid bilayers. , 2000, Biochimica et biophysica acta.

[109]  H. L. Scott,et al.  Modeling the lipid component of membranes. , 2002, Current opinion in structural biology.

[110]  Anthony G Lee,et al.  How lipids affect the activities of integral membrane proteins. , 2004, Biochimica et biophysica acta.

[111]  M. Saier Families of transmembrane sugar transport proteins , 2000, Molecular microbiology.

[112]  Z. Cao,et al.  Mechanisms of colicin binding and transport through outer membrane porins. , 2002, Biochimie.

[113]  David P. Chimento,et al.  Comparative structural analysis of TonB‐dependent outer membrane transporters: Implications for the transport cycle , 2005, Proteins.

[114]  T. Poulos,et al.  Crystallization of cytochromes P450 and substrate-enzyme interactions. , 2004, Current topics in medicinal chemistry.

[115]  S. White,et al.  Membrane protein folding and stability: physical principles. , 1999, Annual review of biophysics and biomolecular structure.

[116]  Helmut Grubmüller,et al.  The dynamics and energetics of water permeation and proton exclusion in aquaporins. , 2005, Current opinion in structural biology.

[117]  C. Sanders,et al.  Bicelles: a model membrane system for all seasons? , 1998, Structure.

[118]  Watt W. Webb,et al.  Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension , 2003, Nature.

[119]  S. Zakharov,et al.  Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes. , 2002, Biochimica et biophysica acta.

[120]  G. Schulz,et al.  Structure of the membrane channel porin from Rhodopseudomonas blastica at 2.0 Å resolution , 1994, Protein science : a publication of the Protein Society.

[121]  C. Sanders,et al.  Reconstitution of membrane proteins into lipid-rich bilayered mixed micelles for NMR studies. , 1995, Biochemistry.

[122]  T. Steitz,et al.  The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis , 1981, Cell.

[123]  J. Hurley,et al.  Signaling and subcellular targeting by membrane-binding domains. , 2000, Annual review of biophysics and biomolecular structure.

[124]  Krzysztof Palczewski,et al.  G protein-coupled receptor rhodopsin. , 2006, Annual review of biochemistry.

[125]  S. Zakharov,et al.  On the role of lipid in colicin pore formation. , 2004, Biochimica et biophysica acta.

[126]  S. White,et al.  How Membranes Shape Protein Structure* , 2001, The Journal of Biological Chemistry.

[127]  Nancy A. Monteiro-Riviere,et al.  Structure and Function of Skin , 2010 .

[128]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[129]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[130]  Gunnar von Heijne,et al.  The machinery of membrane protein assembly. , 2004, Current opinion in structural biology.

[131]  D. E. Green,et al.  Role of lipids in the structure and function of biological membranes. , 1966, Journal of lipid research.

[132]  Martin Karplus,et al.  Biomolecular motors: the F1-ATPase paradigm. , 2004, Current opinion in structural biology.

[133]  G. Tusnády,et al.  Principles governing amino acid composition of integral membrane proteins: application to topology prediction. , 1998, Journal of molecular biology.

[134]  J. Deisenhofer,et al.  TonB-dependent receptors-structural perspectives. , 2002, Biochimica et biophysica acta.

[135]  So Iwata,et al.  Molecular Basis of Proton Motive Force Generation: Structure of Formate Dehydrogenase-N , 2002, Science.

[136]  The photosynthetic apparatus of Rhodobacter sphaeroides. , 1999, Trends in microbiology.

[137]  Satyajit Mayor,et al.  Sorting GPI-anchored proteins , 2004, Nature Reviews Molecular Cell Biology.

[138]  G. Heijne,et al.  Membrane proteins: from sequence to structure. , 1994, Annual review of biophysics and biomolecular structure.

[139]  A. Delcour Solute uptake through general porins. , 2003, Frontiers in bioscience : a journal and virtual library.

[140]  J Deisenhofer,et al.  Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. , 1997, Science.

[141]  D. Fu,et al.  Structure of a glycerol-conducting channel and the basis for its selectivity. , 2000, Science.

[142]  G. von Heijne,et al.  Protein Complexes of the Escherichia coli Cell Envelope* , 2005, Journal of Biological Chemistry.

[143]  K. Locher Structure and mechanism of ABC transporters. , 2004, Current opinion in structural biology.

[144]  T. Rapoport,et al.  The Sec61p Complex Mediates the Integration of a Membrane Protein by Allowing Lipid Partitioning of the Transmembrane Domain , 2000, Cell.

[145]  Charles R Sanders,et al.  Disease-related misassembly of membrane proteins. , 2004, Annual review of biophysics and biomolecular structure.

[146]  S. Iwata,et al.  Protonmotive force generation by a redox loop mechanism , 2003, FEBS letters.

[147]  Jie Liang,et al.  Higher-order interhelical spatial interactions in membrane proteins. , 2003, Journal of molecular biology.

[148]  G. Chang,et al.  Inverted repeat domains in membrane proteins , 2006, FEBS letters.

[149]  J. Bowie Solving the membrane protein folding problem , 2005, Nature.

[150]  D. Engelman,et al.  Helical membrane protein folding, stability, and evolution. , 2000, Annual review of biochemistry.

[151]  G. Schulz,et al.  The structure of porin from Rhodobacter capsulatus at 1.8 Å resolution , 1991, FEBS letters.

[152]  Satoshi Murakami,et al.  Crystal structure of bacterial multidrug efflux transporter AcrB , 2002, Nature.

[153]  N. Isaacs,et al.  Probing the interface between membrane proteins and membrane lipids by X-ray crystallography. , 2001, Trends in biochemical sciences.

[154]  M. J. Lemieux,et al.  Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulation. , 2004, Research in microbiology.

[155]  Youxing Jiang,et al.  Crystal structure and mechanism of a calcium-gated potassium channel , 2002, Nature.

[156]  Pavel Strop,et al.  Crystal Structure of Escherichia coli MscS, a Voltage-Modulated and Mechanosensitive Channel , 2002, Science.

[157]  Ken Jacobson,et al.  A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains , 2002, Science.

[158]  W. A. van der Donk,et al.  Comparison of the properties of prostaglandin H synthase-1 and -2. , 2003, Progress in lipid research.

[159]  G. Schertler Structure of rhodopsin and the metarhodopsin I photointermediate. , 2005, Current opinion in structural biology.

[160]  Hartmut Michel,et al.  Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans , 1995, Nature.

[161]  S. Singer,et al.  The Fluid Mosaic Model of the Structure of Cell Membranes , 1972, Science.

[162]  S. Gruner Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[163]  J Deisenhofer,et al.  Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis. , 1989, Journal of molecular biology.

[164]  G. D. Winget,et al.  Formation of ATP by the adenosine triphosphatase complex from spinach chloroplasts reconstituted together with bacteriorhodopsin. , 1977, Biochimica et biophysica acta.

[165]  T. Rapoport,et al.  Three-dimensional structure of the bacterial protein-translocation complex SecYEG , 2002, Nature.

[166]  Bert van den Berg,et al.  X-ray structure of a protein-conducting channel , 2004, Nature.

[167]  H. Michel,et al.  Crystallisation of membrane proteins mediated by antibody fragments. , 2002, Current opinion in structural biology.

[168]  Andreas Engel,et al.  Structural determinants of water permeation through aquaporin-1 , 2000, Nature.

[169]  J. Deisenhofer,et al.  Crystal structure of the outer membrane active transporter FepA from Escherichia coli , 1999, Nature Structural Biology.

[170]  M. Edidin The state of lipid rafts: from model membranes to cells. , 2003, Annual review of biophysics and biomolecular structure.

[171]  J. Rosenbusch,et al.  High-resolution structures and dynamics of membrane protein--lipid complexes: a critique. , 2001, Current opinion in structural biology.

[172]  T. Tomizaki,et al.  The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å , 1996, Science.

[173]  G. Chang,et al.  Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[174]  G. Schulz β-Barrel membrane proteins , 2000 .

[175]  T. Sixma,et al.  Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. , 2003, Annual review of biophysics and biomolecular structure.

[176]  R. MacKinnon,et al.  Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution , 2001, Nature.

[177]  D. Daleke Regulation of transbilayer plasma membrane phospholipid asymmetry Published, JLR Papers in Press, December 16, 2002. DOI 10.1194/jlr.R200019-JLR200 , 2003, Journal of Lipid Research.

[178]  R. Henderson,et al.  Three-dimensional model of purple membrane obtained by electron microscopy , 1975, Nature.

[179]  B. Dijkstra,et al.  Bacterial phospholipase A: structure and function of an integral membrane phospholipase. , 2000, Biochimica et biophysica acta.

[180]  S. Leibler,et al.  Geometrical aspects of the frustration in the cubic phases of lyotropic liquid crystals. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[181]  B. Sakmann,et al.  Single-channel currents recorded from membrane of denervated frog muscle fibres , 1976, Nature.

[182]  William C. Wimley,et al.  The versatile β-barrel membrane protein , 2003 .

[183]  A. Driessen,et al.  The protein-conducting channel SecYEG. , 2004, Biochimica et biophysica acta.

[184]  J. Eswaran,et al.  Structure and function of TolC: the bacterial exit duct for proteins and drugs. , 2004, Annual review of biochemistry.

[185]  S. Moss,et al.  Annexins: linking Ca2+ signalling to membrane dynamics , 2005, Nature Reviews Molecular Cell Biology.

[186]  Gunnar von Heijne,et al.  Recent advances in the understanding of membrane protein assembly and structure , 1999, Quarterly Reviews of Biophysics.

[187]  Daniel Picot,et al.  The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase , 1995, Nature Structural Biology.

[188]  T. Junne,et al.  Topogenesis of membrane proteins at the endoplasmic reticulum. , 2004, Biochemistry.

[189]  Peter Agre,et al.  Aquaporin water channels (Nobel Lecture). , 2004, Angewandte Chemie.

[190]  R. Gennis Protein-lipid interactions. , 1977, Annual review of biophysics and bioengineering.

[191]  E. Gouaux α-Hemolysin fromStaphylococcus aureus:An Archetype of β-Barrel, Channel-Forming Toxins , 1998 .

[192]  L. Marnett,et al.  Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signaling. , 2005, Biochemical and biophysical research communications.

[193]  M. Nakasako,et al.  Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution , 2000, Nature.

[194]  Edmund R S Kunji,et al.  The role and structure of mitochondrial carriers , 2004, FEBS letters.

[195]  Carola Hunte,et al.  Lipids in membrane protein structures. , 2004, Biochimica et biophysica acta.

[196]  Charles Tanford,et al.  The Hydrophobic Effect: Formation of Micelles and Biological Membranes , 1991 .

[197]  C. Toyoshima,et al.  Structural basis of ion pumping by Ca2+-ATPase , 2004 .

[198]  B. Trumpower,et al.  Protonmotive pathways and mechanisms in the cytochrome bc 1 complex , 2003, FEBS letters.

[199]  M. Malkowski,et al.  The productive conformation of arachidonic acid bound to prostaglandin synthase. , 2000, Science.

[200]  Kai Simons,et al.  Model systems, lipid rafts, and cell membranes. , 2004, Annual review of biophysics and biomolecular structure.

[201]  V. Koronakis TolC – the bacterial exit duct for proteins and drugs , 2003, FEBS letters.

[202]  W. Wimley Toward genomic identification of β‐barrel membrane proteins: Composition and architecture of known structures , 2002, Protein science : a publication of the Protein Society.

[203]  Ehud Y Isacoff,et al.  How does voltage open an ion channel? , 2006, Annual review of cell and developmental biology.

[204]  R. Kadner,et al.  Touch and go: tying TonB to transport , 2003, Molecular microbiology.

[205]  Irmgard Sinning,et al.  SRP-mediated protein targeting: structure and function revisited. , 2004, Biochimica et biophysica acta.

[206]  W. Achouak,et al.  Multiple facets of bacterial porins. , 2001, FEMS microbiology letters.

[207]  A. Wlodawer,et al.  Crystal Structure of the Dimeric C-terminal Domain of TonB Reveals a Novel Fold* , 2001, The Journal of Biological Chemistry.

[208]  W. Dowhan,et al.  Molecular basis for membrane phospholipid diversity: why are there so many lipids? , 1997, Annual review of biochemistry.

[209]  Y. Fujiyoshi,et al.  Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall. , 1999, Journal of molecular biology.

[210]  S. Zakharov,et al.  Insertion intermediates of pore-forming colicins in membrane two-dimensional space. , 2002, Biochimie.

[211]  Kay Diederichs,et al.  Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose , 1998, Nature Structural Biology.

[212]  K. Diederichs,et al.  Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide. , 1998, Science.

[213]  Manfred Burghammer,et al.  Structure of bovine rhodopsin in a trigonal crystal form. , 2003, Journal of molecular biology.

[214]  Gerry McDermott,et al.  Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump , 2003, Science.

[215]  H. Vogel,et al.  Structural biology of bacterial iron uptake systems. , 2001, Current topics in medicinal chemistry.

[216]  T. Kuhn,et al.  The Structure of Scientific Revolutions. , 1964 .