MP2RAGE and Susceptibility‐Weighted Imaging in Lesional Epilepsy at 7T

Surgery is the first choice therapeutic approach in case of drug‐resistant epilepsy. Unfortunately, up to 43% of patients referred for presurgical assessment do not have a lesion detectable by routine 3T magnetic resonance imaging (MRI) (MRI‐negative), although most of them likely have an underlying epileptogenic lesion. Thus, new MRI modalities with increased sensibility for epileptogenic lesions are required. This paper describes the magnetization‐prepared two rapid acquisition gradient echoes (MP2RAGE) and susceptibility‐weighted imaging (SWI) findings at 7T in a series of patients with drug‐resistant epilepsy of different etiologies.

[1]  P. Gosselaar,et al.  7 tesla T2*-weighted MRI as a tool to improve detection of focal cortical dysplasia. , 2016, Epileptic disorders : international epilepsy journal with videotape.

[2]  Tobias Kober,et al.  MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field , 2010, NeuroImage.

[3]  Seyed M. Mirsattari,et al.  Usage of SWI (susceptibility weighted imaging) acquired at 7T for qualitative evaluation of temporal lobe epilepsy patients with histopathological and clinical correlation: An initial pilot study , 2016, Journal of the Neurological Sciences.

[4]  M. Behen,et al.  Clinical and metabolic correlates of cerebral calcifications in Sturge–Weber syndrome , 2017, Developmental medicine and child neurology.

[5]  Gareth Loy,et al.  7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T , 2016, NeuroImage.

[6]  Samuel Wiebe,et al.  Surgical outcomes in lesional and non-lesional epilepsy: A systematic review and meta-analysis , 2010, Epilepsy Research.

[7]  L. Morrison,et al.  Cerebral Cavernous Malformation, Familial , 2016 .

[8]  Josemir W Sander.  The epidemiology of epilepsy revisited , 2003, Current opinion in neurology.

[9]  E. Haacke,et al.  Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 1 , 2008, American Journal of Neuroradiology.

[10]  Boris C. Bernhardt,et al.  Advances in MRI for 'cryptogenic' epilepsies , 2011, Nature Reviews Neurology.

[11]  M. Tosetti,et al.  Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy , 2015, American Journal of Neuroradiology.

[12]  André J. W. van der Kouwe,et al.  Quantitative comparison of cortical surface reconstructions from MP2RAGE and multi-echo MPRAGE data at 3 and 7T , 2014, NeuroImage.

[13]  H. Lüders,et al.  Presurgical evaluation of epilepsy. , 2001, Brain : a journal of neurology.

[14]  Z. Wu,et al.  Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 2 , 2008, American Journal of Neuroradiology.

[15]  M. Tosetti,et al.  7T MRI in focal epilepsy with unrevealing conventional field strength imaging , 2016, Epilepsia.

[16]  P. G. Larsson,et al.  3T phased array MRI improves the presurgical evaluation in focal epilepsies , 2005, Neurology.

[17]  G. Jackson,et al.  Preoperative MRI predicts outcome of temporal lobectomy , 1995, Neurology.

[18]  Z. I. Wang,et al.  The pathology of magnetic-resonance-imaging-negative epilepsy , 2013, Modern Pathology.

[19]  Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia , 2016, Acta Neurologica Belgica.

[20]  Fabrice Bartolomei,et al.  Stereoelectroencephalography in presurgical assessment of MRI-negative epilepsy. , 2007, Brain : a journal of neurology.

[21]  P. Gosselaar,et al.  Seven tesla MRI improves detection of focal cortical dysplasia in patients with refractory focal epilepsy , 2017, Epilepsia open.

[22]  Robert Trampel,et al.  Clinical Neuroimaging Using 7 T MRI: Challenges and Prospects , 2018, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[23]  Bejoy Thomas,et al.  Susceptibility weighted imaging in the diagnostic evaluation of patients with intractable epilepsy , 2009, Epilepsia.