MIOCARDIA: integrating cardiac function and muscular architecture for a better diagnosis

Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with the Computer Vision Center, l'Hospital de la Santa Creu i de Sant Pau, Clínica Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.

[1]  P. Burt Fast filter transform for image processing , 1981 .

[2]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[3]  P. Radeva,et al.  Characterization of ventricular torsion in healthy subjects using Gabor filters and a variational framework , 2006, 2006 Computers in Cardiology.

[4]  T. N. Stevenson,et al.  Fluid Mechanics , 2021, Nature.

[5]  R. Lux,et al.  Effect of Myocardial Fiber Direction on Epicardial Potentials , 1994, Circulation.

[6]  Enric Martí,et al.  A Normalized Framework for the Design of Feature Spaces Assessing the Left Ventricular Function , 2010, IEEE Transactions on Medical Imaging.

[7]  A. M. Scher,et al.  Influence of Cardiac Fiber Orientation on Wavefront Voltage, Conduction Velocity, and Tissue Resistivity in the Dog , 1979, Circulation research.

[8]  R. Winslow,et al.  Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. , 1998, The American journal of physiology.

[9]  O Kittnar,et al.  Mathematical model of the electromechanical heart contractile system--regulatory subsystem physiological considerations. , 2001, Physiological research.

[10]  Erwin Fehlberg,et al.  Klassische Runge-Kutta-Formeln vierter und niedrigerer Ordnung mit Schrittweiten-Kontrolle und ihre Anwendung auf Wärmeleitungsprobleme , 1970, Computing.

[11]  Robert H. Anderson,et al.  Spatial orientation of the ventricular muscle band. , 2002, The Journal of thoracic and cardiovascular surgery.

[12]  J W Covell,et al.  Transverse shear along myocardial cleavage planes provides a mechanism for normal systolic wall thickening. , 1995, Circulation research.

[13]  Lance Williams,et al.  Pyramidal parametrics , 1983, SIGGRAPH.

[14]  Francesc Carreras,et al.  Variational Framework for Assessment of the Left Ventricle Motion , 2008 .

[15]  Leonid Zhukov,et al.  Heart-muscle fiber reconstruction from diffusion tensor MRI , 2003, IEEE Visualization, 2003. VIS 2003..