CMOS front-end architecture for In-Vivo biomedical implantable devices

An integrated front-end architecture for in-vivo detection is presented. The system is conceived to be implanted under the human skin. The powering and communication between this device and an external primary transmitter are based on an inductive link. The presented architecture is oriented to two different approaches, defining a true/false alarm system, based on amperometric or impedance biosensors. The particular case of the amperometric sensor is used to validate the architecture in terms of different integrated modules fabricated in a 0.13 ¿m technology. A potentiostat amplifier has been integrated to control an amperometric biosensor as well as a current sensing method based on a transimpedance amplifier is used to measure the current. It is also introduced the electronics designed for the bio-impedance case.

[1]  H. Wolpert Use of Continuous Glucose Monitoring in the Detection and Prevention of Hypoglycemia , 2007, Journal of diabetes science and technology.

[2]  D.M. Wilson,et al.  A miniaturized lock-in amplifier design suitable for impedance measurements in cells [biological cells] , 2004, Proceedings of IEEE Sensors, 2004..

[3]  B Mattiasson,et al.  Detection of heavy metal ions at femtomolar levels using protein-based biosensors. , 1998, Analytical chemistry.

[4]  M. Sawan,et al.  Wireless Smart Implants Dedicated to Multichannel Monitoring and Microstimulation , 2005, The IEEE/ACS International Conference on Pervasive Services.

[5]  D. Liepmann,et al.  A microneedle-based glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization , 2003, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664).

[6]  Won-Yong Lee,et al.  Amperometric Glucose Biosensor Based on Glucose Oxidase Encapsulated in Carbon Nanotube–Titania–Nafion Composite Film on Platinized Glassy Carbon Electrode , 2007 .

[7]  Mei-Ju Su,et al.  A Study of Ubiquitous Monitor with RFID in an Elderly Nursing Home , 2007, 2007 International Conference on Multimedia and Ubiquitous Engineering (MUE'07).

[8]  Fredy Segura-Quijano,et al.  Simple and efficient inductive telemetry system with data and power transmission , 2008, Microelectron. J..

[9]  P. Miribel-Catala,et al.  Power conditioning circuitry for a self-powered mobile system based on an array of micro PZT generators in a 0.13μm technology , 2007, 2007 IEEE International Symposium on Industrial Electronics.

[10]  Keat Ghee Ong,et al.  Implantable Biosensors for Real-time Strain and Pressure Monitoring , 2008, Sensors.

[11]  D. Barrettino,et al.  Design considerations and recent advances in CMOS-based microsystems for point-of-care clinical diagnostics , 2006, 2006 IEEE International Symposium on Circuits and Systems.

[12]  Omowunmi A Sadik,et al.  Status of biomolecular recognition using electrochemical techniques. , 2009, Biosensors & bioelectronics.

[13]  Chao Yang,et al.  Analysis of On-Chip Impedance Spectroscopy Methodologies for Sensor Arrays , 2006 .

[14]  I. Willner,et al.  Probing Biomolecular Interactions at Conductive and Semiconductive Surfaces by Impedance Spectroscopy: Routes to Impedimetric Immunosensors, DNA‐Sensors, and Enzyme Biosensors , 2003 .

[15]  José A. Gallud,et al.  Using active and passive RFID technology to support indoor location-aware systems , 2008, IEEE Transactions on Consumer Electronics.

[16]  Kris Myny,et al.  An Inductively-Coupled 64b Organic RFID Tag Operating at 13.56MHz with a Data Rate of 787b/s , 2008, 2008 IEEE International Solid-State Circuits Conference - Digest of Technical Papers.

[17]  Shantanu Chakrabartty,et al.  A multi-channel femtoampere-sensitivity conductometric array for biosensing applications , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[18]  G. Ferri,et al.  An integrated analog lock-in amplifier for low-voltage low-frequency sensor interface , 2007, 2007 2nd International Workshop on Advances in Sensors and Interface.

[19]  Robert B. Northrop Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation , 2003 .

[20]  Mohamad Sawan,et al.  An ultra low-power CMOS action potential detector , 2008, 2008 IEEE International Symposium on Circuits and Systems.

[21]  M. Sawan,et al.  Toward Fully Integrated CMOS Based Capacitive Sensor for Lab-on-Chip Applications , 2008, 2008 IEEE International Workshop on Medical Measurements and Applications.

[22]  H.C. Kim,et al.  Needle-type multi-electrode array fabricated by MEMS technology for the hypodermic continuous glucose monitoring system , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[23]  Mark E Meyerhoff,et al.  In vivo chemical sensors: tackling biocompatibility. , 2006, Analytical chemistry.

[24]  Gert Cauwenberghs,et al.  Power harvesting and telemetry in CMOS for implanted devices , 2004, IEEE Transactions on Circuits and Systems I: Regular Papers.

[25]  Eby G. Friedman,et al.  Clock Feedthrough in CMOS Analog Transmission Gate Switches , 2005 .

[26]  R. Jacob Baker,et al.  CMOS Circuit Design, Layout, and Simulation , 1997 .

[27]  P. Vaillancourt,et al.  EM radiation behavior upon biological tissues in a radio-frequency power transfer link for a cortical visual implant , 1997, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136).

[28]  C. Galup-Montoro,et al.  Nanowatt, Sub-nS OTAs, With Sub-10-mV Input Offset, Using Series-Parallel Current Mirrors , 2006, IEEE Journal of Solid-State Circuits.

[29]  R. Hogervorst,et al.  A compact power-efficient 3 V CMOS rail-to-rail input/output operational amplifier for VLSI cell libraries , 1994, Proceedings of IEEE International Solid-State Circuits Conference - ISSCC '94.

[30]  A. Turner,et al.  Home blood glucose biosensors: a commercial perspective. , 2005, Biosensors & bioelectronics.

[31]  Edgar Sanchez-Sinencio,et al.  Transconductance amplifier structures with very small transconductances: a comparative design approach , 2002 .

[32]  Yanbin Li,et al.  Interdigitated microelectrode (IME) impedance sensor for the detection of viable Salmonella typhimurium. , 2004, Biosensors & bioelectronics.

[33]  Joseph Wang,et al.  In vivo glucose monitoring: towards 'Sense and Act' feedback-loop individualized medical systems. , 2008, Talanta.

[34]  A. Erdem,et al.  Single‐Walled Carbon Nanotubes Modified Graphite Electrodes for Electrochemical Monitoring of Nucleic Acids and Biomolecular Interactions , 2009 .

[35]  T. Lee,et al.  A Programmable 0.18-$\mu\hbox{m}$ CMOS Electrochemical Sensor Microarray for Biomolecular Detection , 2006, IEEE Sensors Journal.

[36]  Jin Liu,et al.  A 13.56 MHz RFID transponder front-end with merged load modulation and voltage doubler-clamping rectifier circuits , 2005, 2005 IEEE International Symposium on Circuits and Systems.

[37]  S.K. Islam,et al.  A low-power sensor read-out circuit with FSK telemetry for inductively-powered implant system , 2008, 2008 51st Midwest Symposium on Circuits and Systems.

[38]  E. Alocilja,et al.  A microfabricated biosensor for detecting foodborne bioterrorism agents , 2005, IEEE Sensors Journal.

[39]  Chi-Hoon Jun,et al.  Needle-shaped glucose sensor with multicell electrode fabricated by surface micromachining , 1999, Design, Test, Integration, and Packaging of MEMS/MOEMS.

[40]  C.M. Zierhofer,et al.  Geometric approach for coupling enhancement of magnetically coupled coils , 1996, IEEE Transactions on Biomedical Engineering.

[41]  Richard D. Beach,et al.  Towards a miniature implantable in vivo telemetry monitoring system dynamically configurable as a potentiostat or galvanostat for two- and three-electrode biosensors , 2005, IEEE Transactions on Instrumentation and Measurement.