Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities
暂无分享,去创建一个
Mariella G. Filbin | R. Beroukhim | K. Ligon | B. Tabak | Jean J. Zhao | R. Segal | A. Kung | M. Theisen | S. Ramkissoon | J. Kelleher | S. Buonamici | Yanping Sun | M. Dorsch | D. Shulman | Yu Sun | Qi Wang | Yoko Franchetti | J. Chung | Navid Redjal | S. Dabral | E. Pak | Maria F. Pazyra-Murphy | Maria F Pazyra-Murphy
[1] I. Park,et al. Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. , 2013, Biochemical and biophysical research communications.
[2] G. Santoni,et al. Essential role of Gli proteins in glioblastoma multiforme. , 2013, Current protein & peptide science.
[3] V. Quillien,et al. Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures. , 2012, Neuro-oncology.
[4] C. Giordano,et al. In vitro and in vivo characterization of a novel hedgehog signaling antagonist in human glioblastoma cell lines , 2012, International journal of cancer.
[5] Kenneth K Wang,et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. , 2012, Cancer cell.
[6] W. Sellers,et al. Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor , 2011, Molecular Cancer Therapeutics.
[7] W. Yung,et al. Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells , 2011, Clinical Cancer Research.
[8] H. Fine,et al. Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy , 2011, Glia.
[9] G. Reifenberger,et al. Differential retinoic acid signaling in tumors of long- and short-term glioblastoma survivors. , 2011, Journal of the National Cancer Institute.
[10] Antony Hsieh,et al. Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells , 2011, Journal of cellular physiology.
[11] Shikha Khatri,et al. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency , 2011, Proceedings of the National Academy of Sciences.
[12] Jing Yuan,et al. Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma , 2010, Science Translational Medicine.
[13] P. Wen,et al. Novel medical therapeutics in glioblastomas, including targeted molecular therapies, current and future clinical trials. , 2010, Neuroimaging clinics of North America.
[14] M. Tremblay,et al. New developments in the discovery of small molecule Hedgehog pathway antagonists. , 2010, Current opinion in chemical biology.
[15] T. MacDonald,et al. Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma , 2010, PloS one.
[16] Hongkai Ji,et al. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis , 2010, Proceedings of the National Academy of Sciences.
[17] M. Warmuth,et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. , 2010, ACS medicinal chemistry letters.
[18] Paul Workman,et al. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. , 2010, Cancer research.
[19] C. Sander,et al. Automated Network Analysis Identifies Core Pathways in Glioblastoma , 2010, PloS one.
[20] H. Kotani,et al. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines , 2009, Molecular Cancer.
[21] Mark Bernstein,et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. , 2009, Cell stem cell.
[22] Keith L Black,et al. Hedgehog Signaling Regulates Brain Tumor‐Initiating Cell Proliferation and Portends Shorter Survival for Patients with PTEN‐Coexpressing Glioblastomas , 2008, Stem cells.
[23] David P. Davis,et al. Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction , 2008, Science Signaling.
[24] Gary Box,et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . , 2008, Journal of medicinal chemistry.
[25] B. Zhivotovsky,et al. Death through a tragedy: mitotic catastrophe , 2008, Cell Death and Differentiation.
[26] C. Cordon-Cardo,et al. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. , 2008, Cancer research.
[27] C. Emerson,et al. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[28] Thomas D. Wu,et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. , 2006, Cancer cell.
[29] N. Di Lorenzo,et al. hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines , 2005, British Journal of Cancer.
[30] Martin J. van den Bent,et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. , 2005, The New England journal of medicine.
[31] J. Dancey. Inhibitors of the mammalian target of rapamycin , 2005, Expert opinion on investigational drugs.
[32] B. Manning. Balancing Akt with S6K , 2004, The Journal of cell biology.
[33] K. Aldape,et al. Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR , 2004, Genes, chromosomes & cancer.
[34] D. Rowitch,et al. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors , 2004, Development.
[35] Andrew L Kung,et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[36] J. Slingerland,et al. Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression , 2003, Cell cycle.
[37] Jussi Taipale,et al. Small molecule modulation of Smoothened activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[38] D. Rowitch,et al. Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors , 2000, Molecular and Cellular Biology.
[39] Amy E. Hawkins,et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2009 .