Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations
暂无分享,去创建一个
[1] A. McCulloch,et al. Lentiviral Vectors and Protocols for Creation of Stable hESC Lines for Fluorescent Tracking and Drug Resistance Selection of Cardiomyocytes , 2009, PloS one.
[2] J. Jalife,et al. Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death. , 2015, Circulation research.
[3] Aarti S. Dalal,et al. A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses , 2016, Disease Models & Mechanisms.
[4] Michael Glikson,et al. Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells. , 2012, Journal of the American College of Cardiology.
[5] P. Benzoni,et al. Human derived cardiomyocytes: A decade of knowledge after the discovery of induced pluripotent stem cells , 2016, Developmental dynamics : an official publication of the American Association of Anatomists.
[6] E. Schulze-Bahr,et al. Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction , 2016, Basic Research in Cardiology.
[7] Lior Gepstein,et al. Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters , 2015, Stem cell reports.
[8] U. Ravens,et al. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. , 1994, Circulation research.
[9] K. Morgan,et al. Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes , 2013, European heart journal.
[10] Ki-Suk Kim,et al. Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes. , 2016, Toxicology and applied pharmacology.
[11] Divya Rajamohan,et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation , 2011, European Heart Journal.
[12] A. Mehta,et al. Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes. , 2014, Cardiovascular research.
[13] A. Wilde,et al. Late Sodium Current Inhibition in Acquired and Inherited Ventricular (dys)function and Arrhythmias , 2013, Cardiovascular Drugs and Therapy.
[14] A Varró,et al. The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. , 2001, Cardiovascular research.
[15] Qinlian Zhou,et al. Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells. , 2013, Heart rhythm.
[16] Azra Fatima,et al. The Disease-Specific Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Two Long QT Syndrome Type 3 Patients , 2013, PloS one.
[17] Ronald Wilders,et al. Dynamic clamp: a powerful tool in cardiac electrophysiology , 2006, The Journal of physiology.
[18] S. Priori,et al. Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia , 2016, Cell Death and Disease.
[19] Shinsuke Yuasa,et al. Disease characterization using LQTS-specific induced pluripotent stem cells. , 2012, Cardiovascular research.
[20] James A Thomson,et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. , 2011, American journal of physiology. Heart and circulatory physiology.
[21] 遠山 周吾. Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes , 2013 .
[22] Jean A Boutin,et al. High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. , 2016, American journal of physiology. Heart and circulatory physiology.
[23] L. Maier,et al. Novel aspects of excitation–contraction coupling in heart failure , 2013, Basic Research in Cardiology.
[24] Charles C Hong,et al. Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. , 2015, Journal of molecular and cellular cardiology.
[25] Michael Xavier Doss,et al. Identification and characterization of a transient outward K+ current in human induced pluripotent stem cell-derived cardiomyocytes. , 2013, Journal of molecular and cellular cardiology.
[26] Michael Xavier Doss,et al. Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr , 2012, PloS one.
[27] C. Siu,et al. Overexpression of myocardin induces partial transdifferentiation of human‐induced pluripotent stem cell‐derived mesenchymal stem cells into cardiomyocytes , 2014, Physiological reports.
[28] R. Passier,et al. Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes , 2017, Biochemical and biophysical research communications.
[29] D. Bers,et al. Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts. , 2006, Journal of pharmacological sciences.
[30] Ard Teisman,et al. Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening? , 2009, Journal of pharmacological and toxicological methods.
[31] D. Bers,et al. Na⁺ transport in the normal and failing heart - remember the balance. , 2013, Journal of molecular and cellular cardiology.
[32] C. Bezzina,et al. Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/− and human SCN5A-1795insD+/− iPSC-derived cardiomyocytes , 2017, Cardiovascular research.
[33] Katriina Aalto-Setälä,et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture , 2011, Disease Models & Mechanisms.
[34] P. Lyu,et al. Trypsin-induced proteome alteration during cell subculture in mammalian cells , 2010, Journal of Biomedical Science.
[35] J. Magyar,et al. Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes , 2000, Pflügers Archiv.
[36] Karl-Ludwig Laugwitz,et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. , 2010, The New England journal of medicine.
[37] Milena Bellin,et al. Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue , 2014, Proceedings of the National Academy of Sciences.
[38] Jürgen Hescheler,et al. Human Pluripotent Stem Cell-Derived Cardiomyocytes: Response to TTX and Lidocain Reveals Strong Cell to Cell Variability , 2012, PloS one.
[39] Balázs Horváth,et al. Contribution of IKr and IK1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration? , 2008, Basic Research in Cardiology.
[40] Ruben Coronel,et al. Pacemaker current (I(f)) in the human sinoatrial node. , 2007, European heart journal.
[41] Xuetao Sun,et al. Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes. , 2016, Methods.
[42] Simona Casini,et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome , 2013, The EMBO journal.
[43] Praveen Shukla,et al. Chemically defined generation of human cardiomyocytes , 2014, Nature Methods.
[44] Gordon Keller,et al. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. , 2012, Cell stem cell.
[45] Kirsi Penttinen,et al. Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models , 2015, PloS one.
[46] Jonathan A. Bernstein,et al. Using iPS cells to investigate cardiac phenotypes in patients with Timothy Syndrome , 2011, Nature.
[47] Robert Passier,et al. Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology , 2015, EMBO molecular medicine.
[48] M. Morad,et al. Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. , 2013, Cell calcium.
[49] N. Hellen,et al. The Fallacy of Assigning Chamber Specificity to iPSC Cardiac Myocytes from Action Potential Morphology. , 2016, Biophysical journal.
[50] C. January,et al. IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. , 2016, American journal of physiology. Heart and circulatory physiology.
[51] J. Nerbonne,et al. Molecular physiology of cardiac repolarization. , 2005, Physiological reviews.
[52] A. Leenhardt,et al. Catecholaminergic Polymorphic Ventricular Tachycardia , 2012, Circulation. Arrhythmia and electrophysiology.
[53] Kevin E. Healy,et al. Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia , 2014, Stem cell reports.
[54] Huei-Sheng Vincent Chen,et al. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. , 2010, Stem cells and development.
[55] Wendy K. Chung,et al. Dual Optical Recordings for Action Potentials and Calcium Handling in Induced Pluripotent Stem Cell Models of Cardiac Arrhythmias Using Genetically Encoded Fluorescent Indicators , 2015, Stem cells translational medicine.
[56] Brian J. Stevenson,et al. TECRL, a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT , 2016, EMBO molecular medicine.
[57] A. V. van Ginneken,et al. Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1 , 2015, Front. Physiol..
[58] Antonis A Armoundas,et al. Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. , 2004, American journal of physiology. Heart and circulatory physiology.
[59] Teng Hong Tan,et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells. , 2013, International journal of cardiology.
[60] B. Attali,et al. SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias , 2017, EMBO molecular medicine.
[61] T. Ichisaka,et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.
[62] Deok‐Ho Kim,et al. Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening. , 2017, Biotechnology advances.
[63] Gordon Keller,et al. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry , 2011, The Journal of physiology.
[64] G. Bett,et al. Action Potential Shape Is a Crucial Measure of Cell Type of Stem Cell-Derived Cardiocytes. , 2016, Biophysical journal.
[65] Simona Casini,et al. Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem? , 2015, Stem cells and development.
[66] G. Steinbeck,et al. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. , 1996, Circulation.
[67] Laura Iop,et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia , 2012, EMBO molecular medicine.
[68] S. Priori,et al. Genetics of sudden cardiac death. , 2015, Circulation research.
[69] Adriaan P IJzerman,et al. A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells , 2016, EMBO molecular medicine.
[70] Deborah K. Lieu,et al. Mechanism-Based Facilitated Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes , 2013, Circulation. Arrhythmia and electrophysiology.
[71] Kevin E Healy,et al. In vitro cardiac tissue models: Current status and future prospects. , 2016, Advanced drug delivery reviews.
[72] Marc A. Vos,et al. Probing the Contribution of IKs to Canine Ventricular Repolarization: Key Role for &bgr;-Adrenergic Receptor Stimulation , 2003, Circulation.
[73] Niels Fertig,et al. HTS techniques for patch clamp-based ion channel screening – advances and economy , 2012, Expert opinion on drug discovery.
[74] C. Mummery,et al. Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias , 2012, Front. Physio..
[75] Wataru Shimizu,et al. HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes , 2013 .
[76] U Ravens,et al. L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium. , 1994, Journal of molecular and cellular cardiology.
[77] C. Mummery,et al. Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease , 2012, Circulation.
[78] C. Valdivia,et al. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. , 2005, Journal of molecular and cellular cardiology.
[79] L. Schild,et al. Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients , 2006, Annals of medicine.
[80] Lior Gepstein,et al. Modelling the long QT syndrome with induced pluripotent stem cells , 2011, Nature.
[81] Li Zhiyuan,et al. A Comparison of the Performance and Application Differences Between Manual and Automated Patch-Clamp Techniques , 2012, Current chemical genomics.
[82] T. Ichisaka,et al. Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors , 2008 .
[83] Kevin D. Costa,et al. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[84] A. Baartscheer,et al. Sodium ion transporters as new therapeutic targets in heart failure. , 2008, Cardiovascular & hematological agents in medicinal chemistry.
[85] Samira M. Azarin,et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling , 2012, Proceedings of the National Academy of Sciences.
[86] Peter Kohl,et al. Simultaneous Voltage and Calcium Mapping of Genetically Purified Human Induced Pluripotent Stem Cell–Derived Cardiac Myocyte Monolayers , 2012, Circulation research.
[87] Divya Rajamohan,et al. Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. , 2010, Biochemical Society transactions.
[88] C. Mummery,et al. Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A , 2016, Circulation. Arrhythmia and electrophysiology.
[89] Stuart A Cook,et al. Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes , 2015, Stem Cell Research & Therapy.
[90] José Jalife,et al. The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. , 2005, Heart rhythm.
[91] Denis Noble,et al. Rigorous Phenotyping of Cardiac iPSC Preparations Requires Knowledge of Their Resting Potential(s). , 2016, Biophysical journal.
[92] A. Wilde,et al. Implantable cardioverter-defibrillator harm in young patients with inherited arrhythmia syndromes: A systematic review and meta-analysis of inappropriate shocks and complications. , 2016, Heart rhythm.
[93] C. Remme. Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects , 2013, The Journal of physiology.
[94] S. Yamanaka,et al. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.
[95] Robert Passier,et al. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. , 2010, Stem cell research.
[96] László Virág,et al. Restricting Excessive Cardiac Action Potential and QT Prolongation: A Vital Role for IKs in Human Ventricular Muscle , 2005, Circulation.
[97] M Miragoli,et al. CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia , 2013, Cell Death and Disease.
[98] Xu Xiaoping,et al. Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype. , 2013, American journal of physiology. Heart and circulatory physiology.
[99] M. Morad,et al. Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes. , 2015, Cell calcium.
[100] H. Wichmann,et al. Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. , 2008, The Journal of clinical investigation.
[101] Xuebin B. Yang,et al. Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes , 2016, Stem cells and development.
[102] Arie O. Verkerk,et al. hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities , 2016, Scientific Reports.
[103] Jackie Schiller,et al. Calcium Handling in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes , 2011, PloS one.
[104] Sean P. Palecek,et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells , 2009, Circulation research.
[105] Gordon Keller,et al. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics , 2013, The Journal of general physiology.
[106] Lei Yang,et al. Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. , 2015, Journal of molecular and cellular cardiology.
[107] R. Wilders,et al. Atrio-Sinus Interaction Demonstrated by Blockade of the Rapid Delayed Rectifier Current , 2002, Circulation.
[108] C. Jayle,et al. The Heart Rate‐Lowering Agent Ivabradine Inhibits the Pacemaker Current If in Human Atrial Myocytes , 2007, Journal of cardiovascular electrophysiology.
[109] Lauri Toivonen,et al. The Jervell and Lange-Nielsen Syndrome: Natural History, Molecular Basis, and Clinical Outcome , 2006, Archives des maladies du coeur et des vaisseaux.
[110] Michael George,et al. Planar patch clamp: advances in electrophysiology. , 2008, Methods in molecular biology.
[111] A Varró,et al. Delayed rectifier potassium current in undiseased human ventricular myocytes. , 1998, Cardiovascular research.
[112] Divya Rajamohan,et al. Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform☆ , 2016, Biochimica et biophysica acta.
[113] D. Roden,et al. Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro , 2011, Circulation.
[114] Donald M Bers,et al. Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity , 2013, Circulation.
[115] C. Bezzina,et al. Sodium channel (dys)function and cardiac arrhythmias. , 2010, Cardiovascular therapeutics.
[116] Kyoichi Ono,et al. Cardiac T-type Ca(2+) channels in the heart. , 2010, Journal of molecular and cellular cardiology.
[117] D. Beuckelmann,et al. Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts. , 1998, Circulation.
[118] Ronald A. Li,et al. Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells , 2017, eLife.
[119] S. Nattel,et al. Molecular basis of funny current (If) in normal and failing human heart. , 2008, Journal of molecular and cellular cardiology.
[120] Ofer Binah,et al. Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation , 2012, Journal of cellular and molecular medicine.
[121] B. Kornreich,et al. The patch clamp technique: principles and technical considerations. , 2007, Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
[122] S. Yamanaka,et al. Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia , 2016, PloS one.
[123] Udi Nussinovitch,et al. Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker , 2016, Nature Biotechnology.