Default brain connectivity network in mild traumatic brain injury — preliminary MEG results

In this study, we analyzed brain connectivity profiles from mild traumatic brain injury (mTBI) patients and normal controls. We computed Granger causality measures from magnetoencepha-lographic (MEG) activity obtained at the resting state, in an attempt to understand how the default network is affected by mTBI. Our results show that all subjects exhibit a dense network of peripheral local connections. However, normal controls show an additional network of long-range connections that is drastically reduced mTBI patients. These findings suggest that analysis of functional connectivity patterns may provide a valuable method for early detection of mTBI.

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