Cardiovascular-metabolic impact of adiponectin and aquaporin.

Visceral fat accumulation is located upstream of metabolic syndrome. Recent progress in adipocyte biology has clarified the molecular mechanism for pathophysiology of metabolic syndrome and its related disorders. In this review we summarize adiponectin and aquaporin 7 (AQP7) in the role of metabolic syndrome and cardiovascular diseases.

[1]  T. Funahashi,et al.  Clinical importance of assessment of type 2 diabetes mellitus with visceral obesity. A Japanese perspective. , 2012, Current diabetes reviews.

[2]  K. Clarke,et al.  Modification of myocardial substrate use as a therapy for heart failure , 2006, Nature Clinical Practice Cardiovascular Medicine.

[3]  Y. Matsuzawa.  Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease , 2006, Nature Clinical Practice Cardiovascular Medicine.

[4]  Kok Weng Chan,et al.  Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes* , 2005, Journal of Biological Chemistry.

[5]  H. Lodish,et al.  T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[6]  A. Verkman,et al.  Progressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice , 2005, Journal of Biological Chemistry.

[7]  C. Mantzoros,et al.  Adiponectin and breast cancer risk. , 2004, The Journal of clinical endocrinology and metabolism.

[8]  J. Funder.  Mineralocorticoid Receptors: Distribution and Activation , 2005, Heart Failure Reviews.

[9]  S. Kihara,et al.  Association of serum adiponectin levels with breast cancer risk. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  Philippe Froguel,et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.

[11]  Stefan Neubauer,et al.  The failing heart--an engine out of fuel. , 2007, The New England journal of medicine.

[12]  S. Kihara,et al.  Association of Hypoadiponectinemia With Coronary Artery Disease in Men , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[13]  M. Matsuda,et al.  Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. , 2003, Diabetes.

[14]  W. Stremmel,et al.  Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Philippe Froguel,et al.  Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation* , 2002, The Journal of Biological Chemistry.

[16]  S. Kihara,et al.  Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Y. Nakano,et al.  Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. , 1996, Journal of biochemistry.

[18]  C. Dina,et al.  Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. , 2002, Diabetes.

[19]  C. Bogardus,et al.  Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. , 2002, Diabetes.

[20]  Takeshi Kimura,et al.  Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[21]  M. Matsuda,et al.  Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. , 2002, Diabetes.

[22]  Jan Frystyk,et al.  Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure , 2005, Circulation.

[23]  Jonathan Krakoff,et al.  Adiponectin and development of type 2 diabetes in the Pima Indian population , 2002, The Lancet.

[24]  M. Matsuda,et al.  Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 , 2002, Nature Medicine.

[25]  R. Cardiff,et al.  T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. , 2008, Cancer research.

[26]  H. Boeing,et al.  Adiponectin and protection against type 2 diabetes mellitus , 2003, The Lancet.

[27]  T. Tai,et al.  Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. , 2001, The Journal of clinical endocrinology and metabolism.

[28]  Y. Matsuzawa,et al.  Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. , 1997, Biochemical and biophysical research communications.

[29]  P. Grimaldi,et al.  Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Y. Matsuzawa,et al.  Analysis of an expression profile of genes in the human adipose tissue. , 1997, Gene.

[31]  K. Walsh,et al.  Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype* , 2009, The Journal of Biological Chemistry.

[32]  David Couper,et al.  Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study. , 2004, Diabetes.

[33]  M. Lazar,et al.  A futile metabolic cycle activated in adipocytes by antidiabetic agents , 2002, Nature Medicine.

[34]  M. Matsuda,et al.  Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor γ* , 2001, The Journal of Biological Chemistry.

[35]  S. Kihara,et al.  Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. , 2007, The Journal of clinical investigation.

[36]  H. Lodish,et al.  Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein , 1994, Cell.

[37]  H. Nakagama,et al.  Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition , 2008, Gut.

[38]  S. Kihara,et al.  Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-&agr; , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[39]  S. Kihara,et al.  Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. , 2006, Kidney international.

[40]  T. Ogihara,et al.  Adiponectin and renal function, and implication as a risk of cardiovascular disease. , 2006, The American journal of cardiology.

[41]  T Nakamura,et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[42]  T. Ogihara,et al.  Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. , 2004, Journal of the American College of Cardiology.

[43]  Joanne I. Yeh,et al.  Structures of enterococcal glycerol kinase in the absence and presence of glycerol: correlation of conformation to substrate binding and a mechanism of activation by phosphorylation. , 2004, Biochemistry.

[44]  T. Funahashi,et al.  Metabolic syndrome: Clinical concept and molecular basis , 2007, Annals of medicine.

[45]  M. Matsuda,et al.  Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. , 2002, Diabetes.

[46]  T. Funahashi,et al.  cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). , 1996, Biochemical and biophysical research communications.

[47]  S. Kihara,et al.  Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages , 2004, Circulation.

[48]  C. Dina,et al.  Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. , 2000, American journal of human genetics.

[49]  S. Kihara,et al.  Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. , 2002, Journal of the American Society of Nephrology : JASN.

[50]  S. Kihara,et al.  Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. , 2009, Cardiovascular research.

[51]  B. Kahn,et al.  Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. , 1999, The New England journal of medicine.

[52]  Alessandro Pontillo,et al.  Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. , 2003, JAMA.

[53]  S. Kihara,et al.  The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. , 2009, Cardiovascular research.

[54]  S. Kihara,et al.  Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-&ggr; Agonist Rivoglitazone , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[55]  M. Gladka,et al.  Aquaporin 7: the glycerol aquaeductus in the heart. , 2009, Cardiovascular research.

[56]  T Nakamura,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. , 1999, Biochemical and biophysical research communications.

[57]  C. Dina,et al.  Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p , 2002 .

[58]  J. Flier,et al.  A Transgenic Model of Visceral Obesity and the Metabolic Syndrome , 2001, Science.

[59]  S. Kihara,et al.  Adiponectin-mediated modulation of hypertrophic signals in the heart , 2004, Nature Medicine.

[60]  Philipp E. Scherer,et al.  A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[61]  T. Funahashi,et al.  Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure. , 2009, Journal of the American College of Cardiology.

[62]  M. Igarashi,et al.  Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. , 2003, Diabetes care.

[63]  S. Kihara,et al.  Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. , 2003, Gastroenterology.

[64]  K. Shimamoto,et al.  Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension , 2003, Hypertension.

[65]  J. Weber,et al.  Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[66]  T. Funahashi,et al.  The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. , 2011, Journal of atherosclerosis and thrombosis.

[67]  S. Nielsen,et al.  Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Matsuda,et al.  Role of Adiponectin in Preventing Vascular Stenosis , 2002, The Journal of Biological Chemistry.

[69]  A. Kimmel,et al.  On the Control of Lipolysis in Adipocytes , 1999, Annals of the New York Academy of Sciences.

[70]  M. Matsuda,et al.  Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. , 2002, Diabetes.

[71]  F. Marumo,et al.  Cloning and Functional Expression of a New Water Channel Abundantly Expressed in the Testis Permeable to Water, Glycerol, and Urea* , 1997, The Journal of Biological Chemistry.

[72]  Morihiro Matsuda,et al.  Increased oxidative stress in obesity and its impact on metabolic syndrome. , 2004, The Journal of clinical investigation.

[73]  S. Kihara,et al.  Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms , 2005, Nature Medicine.

[74]  J. Huss,et al.  Nuclear receptor signaling and cardiac energetics. , 2004, Circulation research.

[75]  M. Matsuda,et al.  Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. , 2002, European journal of biochemistry.

[76]  P. Stenvinkel,et al.  Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. , 2004, Kidney international.

[77]  J. Huss,et al.  Mitochondrial energy metabolism in heart failure: a question of balance. , 2005, The Journal of clinical investigation.

[78]  M. Matsuda,et al.  PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. , 2001, Diabetes.

[79]  J. Peters,et al.  Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. , 1998, The Journal of biological chemistry.

[80]  Nader Rifai,et al.  Plasma adiponectin levels and risk of myocardial infarction in men. , 2004, JAMA.

[81]  T. Ogihara,et al.  Hypoadiponectinemia Is an Independent Risk Factor for Hypertension , 2004, Hypertension.

[82]  E. Hardeman,et al.  Cardiac aquaporin expression in humans, rats, and mice. , 2006, American journal of physiology. Heart and circulatory physiology.

[83]  中辻 秀朗.  Reciprocal regulation of natriuretic peptide receptors by insulin in adipose cells , 2011 .

[84]  M. Matsuda,et al.  Genomic Structure and Insulin-mediated Repression of the Aquaporin Adipose (AQPap), Adipose-specific Glycerol Channel* , 2001, The Journal of Biological Chemistry.

[85]  B. Spiegelman,et al.  AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*) , 1996, The Journal of Biological Chemistry.

[86]  L. Bernstein,et al.  Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome. , 2007, American journal of physiology. Endocrinology and metabolism.

[87]  Kathryn N North,et al.  Myocardial water handling and the role of aquaporins. , 2006, Biochimica et biophysica acta.

[88]  D. Tanné,et al.  Effects of Peroxisome Proliferator-Activated Receptor Ligands, Bezafibrate and Fenofibrate, on Adiponectin Level , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[89]  T. Funahashi,et al.  Aquaporins and glycerol metabolism. , 2006, Biochimica et biophysica acta.

[90]  G. Calamita,et al.  Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. , 2011, The Journal of clinical endocrinology and metabolism.

[91]  P. Ruiz-Lozano,et al.  T-cadherin is critical for adiponectin-mediated cardioprotection in mice. , 2010, The Journal of clinical investigation.