Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress.

1. Jasik CB, Lustig RH. Adolescent obesity and puberty: the “perfect storm”. Ann N Y Acad Sci 2008;1135:265–279. 2. Hannon TS, Janosky J, Arslanian SA. Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res 2006;60:759–763. 3. Pralong FP. Insulin and NPY pathways and the control of GnRH function and puberty onset. Mol Cell Endocrinol 2010;324: 82–86. 4. Wright RJ. Perinatal stress and early life programming of lung structure and function. Biol Psychol 2010;84:46–56. 5. Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax 1999;54:1119–1138. 6. Postma DS. Gender differences in asthma development and progression. Gend Med 2007;4 (Suppl B):S133–S146. 7. Noal RB, Menezes AM, Macedo SE, Dumith SC. Childhood body mass index and risk of asthma in adolescence: a systematic review. Obes Rev 2011;12:93–104. 8. Al-Sahab B, Hamadeh MJ, Ardern CI, Tamim H. Early menarche predicts incidence of asthma in early adulthood. Am J Epidemiol 2011;173: 64–70. 9. Vink NM, Postma DS, Schouten JP, Rosmalen JG, Boezen HM. Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents’ Individual Lives Survey (TRAILS) study. J Allergy Clin Immunol 2010;126:498–504, e1–e6. 10. Akinbami L; Centers for Disease Control and Prevention National Center for Health Statistics. The state of childhood asthma, United States, 1980-2005. Adv Data 2006;(381):1–24. 11. Garner R, Kohen D. Changes in the prevalence of asthma among Canadian children. Health Rep 2008;19:45–50. 12. Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sørensen TI, Dunkel L, Himes JH, Teilmann G, Swan SH. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 2008;121:S172–S191. 13. Thuesen BH, Husemoen LL, Hersoug LG, Pisinger C, Linneberg A. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy 2009;39:700–707. 14. Cottrell L, Neal WA, Ice C, Perez MK, Piedimonte G. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med 2011;183:441–448. 15. Arshi M, Cardinal J, Hill RJ, Davies PS, Wainwright C. Asthma and insulin resistance in children. Respirology 2010;15:779–784. 16. Al-Shawwa BA, Al-Huniti NH, DeMattia L, Gershan W. Asthma and insulin resistance in morbidly obese children and adolescents. J Asthma 2007;44:469–473. 17. Melnik BC. Permanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases. Med Hypotheses 2009;73:670–681. 18. Ball GD, Huang TT, Gower BA, Cruz ML, Shaibi GQ, Weigensberg MJ, Goran MI. Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty. J Pediatr 2006; 148:16–22. 19. Labayen I, Ruiz JR, Ortega FB, Harro J, Merenäkk L, Oja L, Veidebaum T, Sjostrom M. Insulin sensitivity at childhood predicts changes in total and central adiposity over a 6-year period. Int J Obes (Lond) 2011;35:1284–1288. 20. Manios Y, Moschonis G, Kourlaba G, Bouloubasi Z, Grammatikaki E, Spyridaki A, Hatzis C, Kafatos A, Fragiadakis GA. Prevalence and independent predictors of insulin resistance in children from Crete, Greece: the Children Study. Diabet Med 2008;25: 65–72. 21. Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F. Early metformin therapy to delay menarche and augment height in girls with precocious pubarche. Fertil Steril 2011;95:727–730. 22. Frontini MG, Srinivasan SR, Berenson GS. Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2003; 27:1398–1404. 23. Sørensen K, Mouritsen A, Mogensen SS, Aksglaede L, Juul A. Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression. J Clin Endocrinol Metab 2010;95:3736–3744. 24. Burrows RA, Leiva LB, Weisstaub G, Lera LM, Albala CB, Blanco E, Gahagan S. High HOMA-IR, adjusted for puberty, relates to the metabolic syndrome in overweight and obese Chilean youths. Pediatr Diabetes 2011;12:212–218. 25. Lee JM, Appugliese D, Kaciroti N, Corwyn RF, Bradley RH, Lumeng JC. Weight status in young girls and the onset of puberty. Pediatrics 2007;119:e624–e630. 26. Aksglaede L, Sørensen K, Petersen JH, Skakkebaek NE, Juul A. Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 2009;123:e932–e939. 27. Ibáñez L, Ong K, de Zegher F, Marcos MV, del Rio L, Dunger DB. Fat distribution in non-obese girls with and without precocious pubarche: central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche. Clin Endocrinol (Oxf) 2003;58: 372–379.

[1]  G. Smaldone,et al.  Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit. , 2014, American journal of respiratory and critical care medicine.

[2]  D. Davies,et al.  Epithelial injury and repair in airways diseases. , 2013, Chest.

[3]  J. Hurley The Perfidious Effect of Topical Placebo: Calibration of Staphylococcus aureus Ventilator-Associated Pneumonia Incidence within Selective Digestive Decontamination Studies versus the Broader Evidence Base , 2013, Antimicrobial Agents and Chemotherapy.

[4]  G. Groothuis,et al.  Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices , 2013, PloS one.

[5]  A. Niimi Structural changes in the airways: cause or effect of chronic cough? , 2011, Pulmonary pharmacology & therapeutics.

[6]  F B Ortega,et al.  Insulin sensitivity at childhood predicts changes in total and central adiposity over a 6-year period , 2011, International Journal of Obesity.

[7]  W. Neal,et al.  Metabolic abnormalities in children with asthma. , 2011, American journal of respiratory and critical care medicine.

[8]  A. Menezes,et al.  Childhood body mass index and risk of asthma in adolescence: a systematic review , 2011, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[9]  A. López-Bermejo,et al.  Early metformin therapy to delay menarche and augment height in girls with precocious pubarche. , 2011, Fertility and sterility.

[10]  J. Hurley Paradoxical ventilator associated pneumonia incidences among selective digestive decontamination studies versus other studies of mechanically ventilated patients: benchmarking the evidence base , 2011, Critical care.

[11]  C. Ardern,et al.  Early menarche predicts incidence of asthma in early adulthood. , 2011, American journal of epidemiology.

[12]  D. Postma,et al.  Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents' Individual Lives Survey (TRAILS) study. , 2010, The Journal of allergy and clinical immunology.

[13]  F. Pralong Insulin and NPY pathways and the control of GnRH function and puberty onset , 2010, Molecular and Cellular Endocrinology.

[14]  J. Hurley Bob Hope, pneumonia, and the counterfactual. , 2010, Chest.

[15]  R. Hill,et al.  Asthma and insulin resistance in children , 2010, Respirology.

[16]  R. Wright,et al.  Perinatal stress and early life programming of lung structure and function , 2010, Biological Psychology.

[17]  D. Curran‐Everett,et al.  Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. , 2010, American journal of respiratory and critical care medicine.

[18]  B. Melnik Permanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases. , 2009, Medical hypotheses.

[19]  D. Thijssen,et al.  Impact of Shear Rate Modulation on Vascular Function in Humans , 2009, Hypertension.

[20]  A. Linneberg,et al.  Insulin resistance as a predictor of incident asthma‐like symptoms in adults , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  D. Tschumperlin,et al.  Chronic intermittent mechanical stress increases MUC5AC protein expression. , 2009, American journal of respiratory cell and molecular biology.

[22]  Y. Kloog,et al.  Mucus secretion and cytoskeletal modifications in cultured nasal epithelial cells exposed to wall shear stresses. , 2008, Biophysical journal.

[23]  D. Kohen,et al.  Changes in the prevalence of asthma among Canadian children. , 2008, Health reports.

[24]  R. Lustig,et al.  Adolescent Obesity and Puberty: The “Perfect Storm” , 2008, Annals of the New York Academy of Sciences.

[25]  S. Swan,et al.  Examination of US Puberty-Timing Data from 1940 to 1994 for Secular Trends: Panel Findings , 2008, Pediatrics.

[26]  Y. Manios,et al.  Prevalence and independent predictors of insulin resistance in children from Crete, Greece: The Children Study , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[27]  Linhong Deng,et al.  Universal physical responses to stretch in the living cell , 2007, Nature.

[28]  B. Al-Shawwa,et al.  Asthma and Insulin Resistance in Morbidly Obese Children and Adolescents , 2007, The Journal of asthma : official journal of the Association for the Care of Asthma.

[29]  Dirkje S Postma,et al.  Gender differences in asthma development and progression. , 2007, Gender medicine.

[30]  L. Akinbami,et al.  The state of childhood asthma, United States, 1980-2005. , 2006, Advance data.

[31]  J. Janosky,et al.  Longitudinal Study of Physiologic Insulin Resistance and Metabolic Changes of Puberty , 2006, Pediatric Research.

[32]  B. Gower,et al.  Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty. , 2006, The Journal of pediatrics.

[33]  S. Holgate,et al.  Epithelial stress and structural remodelling in childhood asthma , 2005, Thorax.

[34]  Roger D. Kamm,et al.  Mechanotransduction through growth-factor shedding into the extracellular space , 2004, Nature.

[35]  Melanie M. Choe,et al.  An in vitro airway wall model of remodeling. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[36]  Jeffrey M Drazen,et al.  Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. , 2003, American journal of respiratory cell and molecular biology.

[37]  P. Howarth,et al.  Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium. , 2003, American journal of respiratory cell and molecular biology.

[38]  P. Howarth,et al.  Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. , 2001, American journal of respiratory cell and molecular biology.

[39]  F. Kauffmann,et al.  Gender differences in airway behaviour over the human life span , 1999, Thorax.