The Natural History of Left Ventricular Filling Abnormalities: Assessment by Two‐Dimensional and Doppler Echocardiography

Doppler and two‐dimensional echocardiography are being increasingly used for the indirect assessment of left ventricular (LV) diastolic function. In this article the alterations in LV filling patterns that occur in patients with LV diastolic function are reviewed in the context of echocardiographic findings. A progression of LV filling abnormalities is presented in the sequential “stages” in which we believe they occur in most cardiac disease states. Patient symptoms, hemodynamics, pulmonary venous flow velocities, and left atrial function associated with the different LV filling patterns are also discussed.

[1]  S Simonsen,et al.  Determination of Pressure Gradient in Mitral Stenosis with a Non‐invasive Ultrasound Doppler Technique , 2009 .

[2]  G. Lupi,et al.  Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major. , 1990, Circulation.

[3]  M. Kern,et al.  Diastolic function in patients undergoing coronary angioplasty: influence of degree of revascularization. , 1990, Journal of the American College of Cardiology.

[4]  J. Vanoverschelde,et al.  Left ventricular filling in dilated cardiomyopathy: relation to functional class and hemodynamics. , 1990, Journal of the American College of Cardiology.

[5]  A. Tajik,et al.  Relation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditions. , 1990, Circulation.

[6]  R. Bonow,et al.  Left ventricular hypertrophy and impaired diastolic filling in essential hypertension. Diastolic mechanisms for systolic dysfunction during exercise. , 1990, Circulation.

[7]  A. Tajik,et al.  Significance of Doppler indices of diastolic filling of the left ventricle: comparison with invasive hemodynamics in a canine model. , 1989, American heart journal.

[8]  C. H. Park,et al.  Phase differences between left ventricular wall motion and transmitral flow in man: evidence for involvement of ventricular restoring forces in normal rapid filling. , 1989, International journal of cardiology.

[9]  K Kristoffersen,et al.  Cross sectional early mitral flow velocity profiles from colour Doppler. , 1989, British heart journal.

[10]  M. Kern,et al.  Influence of alteration in preload on the pattern of left ventricular diastolic filling as assessed by Doppler echocardiography in humans. , 1989, Circulation.

[11]  Jean Charles Gilbert,et al.  Determinants of left ventricular filling and of the diastolic pressure-volume relation. , 1989, Circulation research.

[12]  J. Seward,et al.  Doppler characterization of left ventricular diastolic function in cardiac amyloidosis. , 1989, Journal of the American College of Cardiology.

[13]  W. Rutishauser,et al.  Doppler assessment of left ventricular diastolic filling during brief coronary occlusion. , 1989, American heart journal.

[14]  N. Reichek,et al.  Alterations in diastolic function in response to progressive left ventricular hypertrophy. , 1989, Journal of the American College of Cardiology.

[15]  A. Tajik,et al.  Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Part II. Clinical studies. , 1989, Mayo Clinic proceedings.

[16]  R L Popp,et al.  Differentiation of Constrictive Pericarditis and Restrictive Cardiomyopathy by Doppler Echocardiography , 1989, Circulation.

[17]  M. Kern,et al.  Left Ventricular Diastolic Function: Comparison of Pulsed Doppler Echocardiographic and Hemodynamic Indexes in Subjects With and Without Coronary Artery Disease , 1989, Journal of the American College of Cardiology.

[18]  P. Ludbrook,et al.  The transmitral pressure-flow velocity relation. Effect of abrupt preload reduction. , 1988, Circulation.

[19]  A. Weyman,et al.  Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measured by Doppler echocardiography. , 1988, Circulation.

[20]  P. Ludbrook,et al.  Transmitral pressure-flow velocity relation. Importance of regional pressure gradients in the left ventricle during diastole. , 1988, Circulation.

[21]  E. Sonnenblick,et al.  Mitral anulus motion. Relation to pulmonary venous and transmitral flows in normal subjects and in patients with dilated cardiomyopathy. , 1988, Circulation.

[22]  R L Popp,et al.  Relation of Transmitral Flow Velocity Patterns to Left Ventricle Diastolic Function: New Insights From a Combined Hemodynamic and Doppler Echocardiographic Study , 1988, Journal of the American College of Cardiology.

[23]  A. Tajik,et al.  Doppler echocardiographic observations during percutaneous aortic balloon valvuloplasty. , 1988, Journal of the American College of Cardiology.

[24]  L. Hatle,et al.  Demonstration of restrictive ventricular physiology by Doppler echocardiography. , 1988, Journal of the American College of Cardiology.

[25]  S. Nakatani,et al.  Effects of changes in coronary stenosis on left ventricular diastolic filling assessed with pulsed Doppler echocardiography. , 1988, Journal of the American College of Cardiology.

[26]  R. Kerber,et al.  Influence of sublingual nitroglycerin on diastolic transmitral flow velocities in normal subjects. , 1988, The American journal of cardiology.

[27]  A. Heringa,et al.  Normal diastolic filling patterns of the left ventricle. , 1988, European heart journal.

[28]  H. Kennedy,et al.  Evaluation of left ventricular systolic and diastolic dysfunction during transient myocardial ischemia produced by angioplasty. , 1987, Journal of the American College of Cardiology.

[29]  A. Weyman,et al.  Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. , 1987, Journal of the American College of Cardiology.

[30]  W. Gaasch,et al.  Right ventricular pacing reduces the rate of left ventricular relaxation and filling. , 1987, Journal of the American College of Cardiology.

[31]  M. Quiñones,et al.  Quantification of atrial contribution to left ventricular filling by pulsed Doppler echocardiography and the effect of age in normal and diseased hearts. , 1987, The American journal of cardiology.

[32]  E. Topol,et al.  Pulsed Doppler assessment of left ventricular diastolic filling in coronary artery disease before and immediately after coronary angioplasty. , 1987, The American journal of cardiology.

[33]  M. Yokota,et al.  Effects of diltiazem on left ventricular diastolic behavior in patients with hypertrophic cardiomyopathy: evaluation with exercise pulsed Doppler echocardiography. , 1987, Journal of the American College of Cardiology.

[34]  George A. Williams,et al.  Effect of aging on left ventricular diastolic filling in normal subjects. , 1987, The American journal of cardiology.

[35]  J. Smallhorn,et al.  Pulsed Doppler echocardiographic assessment of extraparenchymal pulmonary vein flow. , 1987, Journal of the American College of Cardiology.

[36]  A. DeMaria,et al.  Assessment of left ventricular diastolic function: comparison of Doppler echocardiography and gated blood pool scintigraphy. , 1986, Journal of the American College of Cardiology.

[37]  J. Gardin,et al.  Pulsed Doppler echocardiographic study of left ventricular filling in dilated cardiomyopathy. , 1986, The American journal of cardiology.

[38]  Y Ishida,et al.  Left ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure. , 1986, Circulation.

[39]  J. Gardin,et al.  Left ventricular filling in hypertrophic cardiomyopathy: a pulsed Doppler echocardiographic study. , 1986, Journal of the American College of Cardiology.

[40]  J. Gardin,et al.  Effect of imaging view and sample volume location on evaluation of mitral flow velocity by pulsed Doppler echocardiography. , 1986, The American journal of cardiology.

[41]  T. LeJemtel,et al.  Atrial contraction is an important determinant of pulmonary venous flow. , 1986, Journal of the American College of Cardiology.

[42]  R. Bonow,et al.  Noninvasive assessment of left ventricular diastolic function: comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. , 1986, Journal of the American College of Cardiology.

[43]  S. Gidding,et al.  Doppler evaluation of left ventricular diastolic filling in children with systemic hypertension. , 1985, The American journal of cardiology.

[44]  F. Rademakers,et al.  Analysis of relaxation in the evaluation of ventricular function of the heart. , 1985, Progress in cardiovascular diseases.

[45]  S. Laniado,et al.  Pulmonary venous flow pattern--its relationship to cardiac dynamics. A pulsed Doppler echocardiographic study. , 1985, Circulation.

[46]  G. Heller,et al.  Simultaneous assessment of left ventricular systolic and diastolic dysfunction during pacing-induced ischemia. , 1985, Circulation.

[47]  H. Sawada,et al.  Noninvasive assessment of left and right ventricular filling in myocardial infarction with a two-dimensional Doppler echocardiographic method. , 1985, Journal of the American College of Cardiology.

[48]  M. Quiñones,et al.  Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: comparison with cineangiography. , 1985, Circulation.

[49]  M. Verani,et al.  Alteration of diastolic filling rate during exercise radionuclide angiography: a highly sensitive technique for detection of coronary artery disease. , 1984, Circulation.

[50]  F. Van de Werf,et al.  Diastolic properties of the left ventricle in normal adults and in patients with third heart sounds. , 1984, Circulation.

[51]  W. McKenna,et al.  Left ventricular hypertrophy. Relation of structure to diastolic function in hypertension. , 1984, British heart journal.

[52]  K. Miyatake,et al.  Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. , 1984, The American journal of cardiology.

[53]  Y. Hirota,et al.  Idiopathic restrictive cardiomyopathy: differences of left ventricular relaxation and diastolic wave forms from constrictive pericarditis. , 1983, The American journal of cardiology.

[54]  J. Shaver,et al.  A critical appraisal of diastolic time intervals as a measure of relaxation in left ventricular hypertrophy. , 1983, Circulation.

[55]  M. Hori,et al.  [Role of left ventricular relaxation on transmitral flow dynamics during early diastole: pulsed Doppler flowmetry]. , 1983, Journal of cardiography.

[56]  R. Magorien,et al.  Assessment of Left Ventricular Pressure‐Volume Relations Using Gated Radionuclide Angiography, Echocardiography, and Micromanometer Pressure Recordings: A New Method for Serial Measurements of Systolic and Diastolic Function in Man , 1983, Circulation.

[57]  J. Carroll,et al.  Left ventricular relaxation in patients with left ventricular hypertrophy secondary to aortic valve disease. , 1982, Circulation.

[58]  J. Polak,et al.  Resting early peak diastolic filling rate: a sensitive index of myocardial dysfunction in patients with coronary artery disease. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[59]  J. Tanouchi,et al.  Transmitral blood flow reflecting diastolic behavior of the left ventricle in health and disease--a study by pulsed Doppler technique. , 1982, Japanese circulation journal.

[60]  L. Brasseur,et al.  Relationship Between Changes in Left Ventricular Inotropic State and Relaxation in Normal Subjects and in Patients with Coronary Artery Disease , 1981, Circulation.

[61]  E L Yellin,et al.  Mechanisms of mitral valve motion during diastole. , 1981, The American journal of physiology.

[62]  Michael V. Green,et al.  Impaired Left Ventricular Diastolic Filling in Patients with Coronary Artery Disease: Assessment with Radionuclide Angiography , 1981, Circulation.

[63]  R. Miller,et al.  Left Ventricular Diastolic Performance At Rest and During Exercise in Patients With Coronary Artery Disease: Assessment with First‐pass Radionuclide Angiography , 1981, Circulation.

[64]  H N Sabbah,et al.  Pressure‐Diameter Relations during Early Diastole in Dogs: Incompatibility with the Concept of Passive Left Ventricular Filling , 1981, Circulation research.

[65]  Y. Hirota,et al.  A Clinical Study of Left Ventricular Relaxation , 1980, Circulation.

[66]  R. W. Brower,et al.  Interaction of left ventricular relaxation and filling during early diastole in human subjects. , 1980, The American journal of cardiology.

[67]  B. Rajagopalan,et al.  Blood flow in pulmonary veins: I. Studies in dog and man. , 1979, Cardiovascular research.

[68]  G. Mudge,et al.  Factors Contributing to Altered Left Ventricular Diastolic Properties During Angina Pectoris , 1979, Circulation.

[69]  L Hatle,et al.  Noninvasive assessment of pressure drop in mitral stenosis by Doppler ultrasound. , 1978, British heart journal.

[70]  J. Sanderson,et al.  Left ventricular filling in hypertrophic cardiomyopathy. An angiographic study. , 1977, British heart journal.

[71]  D. Gibson,et al.  Echocardiographic assessment of abnormal left ventricular relaxation in man. , 1976, British heart journal.

[72]  D G Gibson,et al.  Analysis of left ventricular wall movement during isovolumic relaxation and its relation to coronary artery disease. , 1976, British heart journal.

[73]  D. Gibson,et al.  Measurement of peak rates of left ventricular wall movement in man. Comparison of echocardiography with angiography. , 1975, British heart journal.

[74]  J. S. Cole,et al.  Dynamic Determinants of Left Ventricular Diastolic Pressure‐Volume Relations in Man , 1975, Circulation.

[75]  K E Hammermeister,et al.  The rate of change of left ventricular volume in man. II. Diastolic events in health and disease. , 1974, Circulation.

[76]  S. H. Dixon,et al.  The influence of atrial contraction and mitral valve mechanics on ventricular filling , 1969 .

[77]  E. Braunwald,et al.  Impaired Rate of Left Ventricular Filling in Idiopathic Hypertrophic Subaortic Stenosis and Valvular Aortic Stenosis , 1968, Circulation.

[78]  R. Russell,et al.  THE RELATION OF AGE TO THE DURATION OF CONTRACTION, EJECTION, AND RELAXATION OF THE NORMAL HUMAN HEART. , 1964, American heart journal.

[79]  C. Appleton,et al.  Influence of incremental changes in heart rate on mitral flow velocity: assessment in lightly sedated, conscious dogs. , 1991, Journal of the American College of Cardiology.

[80]  E L Yellin,et al.  Left ventricular filling dynamics and diastolic function. , 1990, Progress in cardiovascular diseases.

[81]  O. Smiseth,et al.  Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation. , 1990, Circulation.

[82]  S. Hunt,et al.  A hemodynamic and Doppler echocardiographic study of ventricular function in long-term cardiac allograft recipients. Etiology and prognosis of restrictive-constrictive physiology. , 1989, Circulation.

[83]  H. Ihlen,et al.  Reproducibility of transmitral flow velocity parameters measured by pulsed Doppler echocardiography , 1988 .

[84]  J. Seward,et al.  Two-dimensional and Doppler echocardiographic assessment of infiltrative cardiomyopathy. , 1988, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[85]  J. Gardin,et al.  Doppler Transmitral Flow Velocity Parameters: Relationship between Age, Body Surface Area, Blood Pressure and Gender in Normal Subjects , 1987 .

[86]  J. Flaherty Role of nitrates in acute myocardial infarction. , 1987, The American journal of cardiology.

[87]  J. Shaver,et al.  Isovolumic relaxation period in hypertrophic cardiomyopathy. , 1984, Journal of the American College of Cardiology.

[88]  W. Ohley,et al.  Ischemia-induced impairment of left ventricular relaxation: relation to reduced diastolic filling rates of the left ventricle. , 1983, American heart journal.

[89]  D. Mathey,et al.  Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: an echocardiographic study. , 1980, The American journal of cardiology.

[90]  E. Skagseth Pulmonary vein flow pattern in man during thoracotomy. , 1976, Scandinavian journal of thoracic and cardiovascular surgery.

[91]  W. Grossman,et al.  Impaired left ventricular relaxation during pacing-induced ischemia. , 1973, The American journal of cardiology.

[92]  W. Couldwell CLINICAL STUDIES , 2022 .