Regulation of HuR structure and function by dihydrotanshinone-I
暂无分享,去创建一个
M. Gorospe | E. Novellino | C. Luchinat | E. Dassi | A. Quattrone | P. Seneci | D. Dixon | L. Cerofolini | M. Fragai | Ranjan Preet | E. Lehrmann | A. Provenzani | L. Marinelli | V. D'Agostino | C. Zucal | I. Bonomo | S. Giuntini | L. Manzoni | P. Lal | M. S. Fairlamb | Carmelo Fuccio | Vikalp Vishwakarma | E. Biasini | D. di Maio | K. Abdelmohsen | V. D’Agostino | R. Munk | Saioa R Elezgarai | Shanado Williams | Alessandro Provenzani
[1] E. Cheung,et al. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype , 2017, Molecular Cancer Research.
[2] D. Dixon,et al. Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis , 2016, Oncotarget.
[3] A. Inga,et al. The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer. , 2016, Cancer research.
[4] W. Wu,et al. Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. , 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[5] M. Gaestel,et al. Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function , 2015, Scientific Reports.
[6] M. Gorospe,et al. Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637 , 2015, Molecular and Cellular Biology.
[7] F. Almeida,et al. 1H, 15N and 13C resonance assignments of the RRM1 domain of the key post-transcriptional regulator HuR , 2015, Biomolecular NMR assignments.
[8] D. Ivanov,et al. Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation , 2015, PloS one.
[9] G. Wertheim,et al. B Cell–Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell–Dependent Immune Response In Vivo , 2015, The Journal of Immunology.
[10] J. Karanicolas,et al. Abstract 2449: Targeting an “undruggable” RNA-binding protein: Discovery of small molecule inhibitors of HuR for novel breast cancer therapy , 2015 .
[11] Yu-Chih Liang,et al. 15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies , 2015, International journal of molecular sciences.
[12] A. Provenzani,et al. Targeting the multifaceted HuR protein, benefits and caveats. , 2015, Current drug targets.
[13] D. Dixon,et al. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. , 2015, ACS chemical biology.
[14] Kathi,et al. University of Birmingham The RNA-binding protein HuR is essential for the B cell antibody response , 2016 .
[15] F. Blanco,et al. The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets , 2014, RNA biology.
[16] K. Masuda,et al. HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress , 2014, Molecular and Cellular Biology.
[17] A. Quattrone,et al. Loss of Protein Kinase Cδ/HuR Interaction Is Necessary to Doxorubicin Resistance in Breast Cancer Cell Lines , 2014, The Journal of Pharmacology and Experimental Therapeutics.
[18] Félix Araújo-Pérez,et al. The Role of HuR in the Post-Transcriptional Regulation of Interleukin-3 in T Cells , 2014, PloS one.
[19] M. Gorospe,et al. Conditional Knockout of the RNA-Binding Protein HuR in CD4+ T Cells Reveals a Gene Dosage Effect on Cytokine Production , 2014, Molecular medicine.
[20] D. Auboeuf,et al. A recently evolved class of alternative 3′-terminal exons involved in cell cycle regulation by topoisomerase inhibitors , 2014, Nature Communications.
[21] Alessandro Fatica,et al. A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis , 2014, Molecular cell.
[22] D. Svergun,et al. Examination of Matrix Metalloproteinase-1 in Solution , 2013, The Journal of Biological Chemistry.
[23] A. Provenzani,et al. A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation , 2013, PloS one.
[24] E. Chen,et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.
[25] Zexian Liu,et al. The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding. , 2013, Acta crystallographica. Section D, Biological crystallography.
[26] I. Díaz-Moreno,et al. HuR thermal stability is dependent on domain binding and upon phosphorylation , 2012, European Biophysics Journal.
[27] M. Teng,et al. Crystal structure of two tandem RNA recognition motifs of Human antigen R , 2012 .
[28] Lennart Nilsson,et al. Magnesium Ion-Water Coordination and Exchange in Biomolecular Simulations. , 2012, Journal of chemical theory and computation.
[29] A. Quattrone,et al. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells , 2012, Molecular Cancer.
[30] W. Zwart,et al. Supplementary Materials and Methods , 2013 .
[31] Myriam Gorospe,et al. HuR function in disease. , 2012, Frontiers in bioscience.
[32] Chen Wang,et al. Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation , 2012, Molecular and Cellular Biochemistry.
[33] D. Dixon,et al. The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2 , 2011, Molecular Cancer Research.
[34] Uwe Ohler,et al. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. , 2011, Molecular cell.
[35] N. Rajewsky,et al. Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. , 2011, Molecular cell.
[36] Piotr Cieplak,et al. R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments , 2011, Nucleic Acids Res..
[37] M. Gorospe,et al. Chemokine Transcripts as Targets of the RNA-Binding Protein HuR in Human Airway Epithelium , 2011, The Journal of Immunology.
[38] G. M. Wilson,et al. Different modes of interaction by TIAR and HuR with target RNA and DNA , 2011, Nucleic acids research.
[39] Kotb Abdelmohsen,et al. Posttranscriptional regulation of cancer traits by HuR , 2010, Wiley interdisciplinary reviews. RNA.
[40] Piotr Cieplak,et al. The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building. , 2010, Physical chemistry chemical physics : PCCP.
[41] Manfred Auer,et al. The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism. , 2010, Journal of molecular biology.
[42] P. Hylemon,et al. Role of RNA‐binding protein HuR and CUGBP1 in LPS‐induced Interleukin‐6 Expression in Macrophages , 2010 .
[43] Yibo Wu,et al. GOSemSim: an R package for measuring semantic similarity among GO terms and gene products , 2010, Bioinform..
[44] R. Dror,et al. Improved side-chain torsion potentials for the Amber ff99SB protein force field , 2010, Proteins.
[45] W. Park,et al. Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA , 2009, Experimental & Molecular Medicine.
[46] N. Mukherjee,et al. Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR1 , 2009, The Journal of Immunology.
[47] D. Svergun,et al. Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1)* , 2009, Journal of Biological Chemistry.
[48] S. Srikantan,et al. Ubiquitin‐mediated proteolysis of HuR by heat shock , 2009, The EMBO journal.
[49] K. Khabar,et al. Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation , 2009, Nucleic acids research.
[50] S. Srikantan,et al. Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype , 2008, Oncogene.
[51] J. M. Izquierdo. Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition* , 2008, Journal of Biological Chemistry.
[52] D. Svergun,et al. Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. , 2008, Journal of the American Chemical Society.
[53] Yu-Chih Liang,et al. Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis. , 2007, Biochemical pharmacology.
[54] Johannes Ottl,et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. , 2007, Nature chemical biology.
[55] Kotb Abdelmohsen,et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. , 2007, Molecular cell.
[56] P. Kollman,et al. Automatic atom type and bond type perception in molecular mechanical calculations. , 2006, Journal of molecular graphics & modelling.
[57] Laxmikant V. Kalé,et al. Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..
[58] C. Dominguez,et al. The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression , 2005, The FEBS journal.
[59] J. Havel,et al. Inhibition of Protein-Protein Interactions: Non-Cellular Assay Formats , 2012 .
[60] M. Gorospe,et al. Identification of a target RNA motif for RNA-binding protein HuR. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[61] Myriam Gorospe,et al. Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence , 2001, Molecular and Cellular Biology.
[62] G. Weiss,et al. Combinatorial alanine-scanning. , 2001, Current opinion in chemical biology.
[63] J. A. Steitz,et al. HuR and mRNA stability , 2001, Cellular and Molecular Life Sciences CMLS.
[64] J. García de la Torre,et al. HYDRONMR: prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations. , 2000, Journal of magnetic resonance.
[65] Myriam Gorospe,et al. HuR Regulates p21 mRNA Stabilization by UV Light , 2000, Molecular and Cellular Biology.
[66] J. Hus,et al. Efficient analysis of macromolecular rotational diffusion from heteronuclear relaxation data , 2000, Journal of biomolecular NMR.
[67] G. Hirose,et al. Binding of neuronal ELAV‐like proteins to the uridine‐rich sequence in the 3′‐untranslated region of tumor necrosis factor‐α messenger RNA , 1999, FEBS letters.
[68] J. Steitz,et al. HNS, a nuclear-cytoplasmic shuttling sequence in HuR. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[69] A. Levy,et al. Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR* , 1998, The Journal of Biological Chemistry.
[70] P. Kollman,et al. A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules , 1995 .
[71] Jeffrey W. Peng,et al. [20] Investigation of protein motions via relaxation measurements , 1994 .
[72] G. Wagner,et al. Investigation of protein motions via relaxation measurements. , 1994, Methods in enzymology.
[73] P. Kollman,et al. A well-behaved electrostatic potential-based method using charge restraints for deriving atomic char , 1993 .
[74] M Ikura,et al. Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible. , 1992, Biochemistry.
[75] L. Kay,et al. Pulse sequences for removal of the effects of cross correlation between dipolar and chemical-shift anisotropy relaxation mechanisms on the measurement of heteronuclear T1 and T2 values in proteins , 1992 .