Equilibrium swelling behavior of pH-sensitive hydrogels

The equilibrium swelling behavior of hydrogels sensitive to pH or ionic strength changes of the swelling medium was studied using new structural models which are based on the Flory—Huggins thermodynamic theory, the rubber elasticity theory, and ionic interaction deviations therefrom. The number average molecular weight between crosslinks was related to equilibrium swelling characteristics, the thermodynamic compatability of the polymer—swelling agent system, the ionic charges, the pKa of the ionizable polymer moieties, and the pH and ionic strength of the surrounding medium. The models have predictive, correlative and design capabilities.

[1]  S. Yalkowsky.  Topics in Pharmaceutical Sciences , 1983 .

[2]  D. Eustace,et al.  Polymer compatibility and interpolymer association in the poly(acrylic acid)–polyacrylamide–water ternary system , 1988 .

[3]  S. K. Chatterjee,et al.  Influence of preferential solvation on the interpolymer complex formation between methacrylic acid-methacrylamide copolymer and poly(vinyl pyrrolidone) , 1986 .

[4]  Toyoichi Tanaka,et al.  Phase transitions in crosslinked gels of natural polymers , 1987 .

[5]  K. Dušek,et al.  Hydrophilic gels based on copolymers of 2‐hydroxyethyl methacrylate with methacrylamide and acrylamide , 1975 .

[6]  J. Kopeček,et al.  Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers. 3. Targeting by incorporation of galactosamine residues. Effect of route of administration , 1987 .

[7]  J. Šulc,et al.  Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2-hydroxyethyl methacrylate). , 1987, Journal of biomedical materials research.

[8]  Toyoichi Tanaka,et al.  Swelling of Ionic Gels : Quantitative Performance of the Donnan Theory , 1984 .

[9]  P. Flory,et al.  STATISTICAL MECHANICS OF CROSS-LINKED POLYMER NETWORKS II. SWELLING , 1943 .

[10]  Edward L Cussler,et al.  Chemical aspects of gel extraction , 1986 .

[11]  N. Peppas,et al.  POLY(VINYL ALCOHOL) HYDROGELS: REINFORCEMENT OF RADIATION-CROSSLINKED NETWORKS BY CRYSTALLIZATION. , 1976 .

[12]  M. Ilavský,et al.  Deformational, swelling, and potentiometric behavior of ionized poly(methacrylic acid) gels. II. Experimental results , 1975 .

[13]  J. Andrade.  Hydrogels for medical and related applications , 1976 .

[14]  S. Lifson,et al.  Equation of swelling for polyelectrolyte gels , 1951 .

[15]  Shao-Tang Sun,et al.  Phase transitions in ionic gels , 1980 .