Graph Neural Network Emulation of Cardiac Mechanics

This paper compares the performance of two graph neural network architectures on the emulation of a cardiac mechanic model of the left ventricle of the heart. These models can be applied directly on the same computational mesh of the left ventricle geometry that is used by the expensive numerical forward solver, precluding the need for a low-order approximation of the true geometry. Our results show that these emulation approaches incur negligible loss in accuracy compared in the forward simulator, while making predictions multiple orders of magnitude more quickly, raising the prospect for their use in both forward and inverse problems in cardiac modelling.

[1]  Gerhard A Holzapfel,et al.  Constitutive modelling of passive myocardium: a structurally based framework for material characterization , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[2]  Robert B. Gramacy,et al.  Surrogates: Gaussian Process Modeling, Design, and Optimization for the Applied Sciences , 2020 .

[3]  K Miller,et al.  Biomechanics of soft tissues. , 2000, Medical science monitor : international medical journal of experimental and clinical research.

[4]  Colin Berry,et al.  Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction , 2017, Journal of The Royal Society Interface.

[5]  Henrik Finsberg pulse: A python package based on FEniCS for solving problems in cardiac mechanics , 2019, J. Open Source Softw..

[6]  Colin Berry,et al.  Advances in computational modelling for personalised medicine after myocardial infarction , 2017, Heart.

[7]  Jernej Barbic,et al.  A Deep Emulator for Secondary Motion of 3D Characters , 2021, 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).

[8]  Martyn P. Nash,et al.  Deep Learning Over Reduced Intrinsic Domains for Efficient Mechanics of the Left Ventricle , 2020, Frontiers in Physics.

[9]  G. Plank,et al.  A Novel Rule-Based Algorithm for Assigning Myocardial Fiber Orientation to Computational Heart Models , 2012, Annals of Biomedical Engineering.

[10]  Meire Fortunato,et al.  Learning Mesh-Based Simulation with Graph Networks , 2020, ArXiv.

[11]  Runze Li,et al.  Design and Modeling for Computer Experiments , 2005 .

[12]  Michael S. Sacks,et al.  Insights into the passive mechanical behavior of left ventricular myocardium using a robust constitutive model based on full 3D kinematics. , 2020, Journal of the mechanical behavior of biomedical materials.