Does tranexamic acid improve bleeding, transfusion, and hemoglobin level in patients undergoing multi-level spine surgery? A systematic review and meta-analysis.

[1]  A. Gonzalez Della Valle,et al.  Topical Tranexamic Acid in Revision Total Knee Arthroplasty Reduces Transfusion Rates and May Be Associated With Earlier Recovery. , 2019, The Journal of arthroplasty.

[2]  S. Bartol,et al.  Intravenous and Oral Tranexamic Acid Are Equivalent at Reducing Blood Loss in Thoracolumbar Spinal Fusion: A Prospective Randomized Trial , 2019, Spine.

[3]  J. Su,et al.  Effect of Tranexamic Acid in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. , 2019, World neurosurgery.

[4]  A. Rodríguez-Arias,et al.  Prevention of postoperative bleeding in hip fractures treated with prosthetic replacement: efficacy and safety of fibrin sealant and tranexamic acid. A randomised controlled clinical trial (TRANEXFER study) , 2018, Archives of Orthopaedic and Trauma Surgery.

[5]  Feng Qiao,et al.  The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis , 2018, Medicine.

[6]  Ayman A. Sallam,et al.  Evaluation of Local Intra-Pleural Application of Tranexamic Acid on Postoperative Blood Loss in Lung Decortication Surgery, A Prospective, Randomized, Double-Blind, Placebo-controlled Study , 2018, Annals of cardiac anaesthesia.

[7]  R. Tabrizi,et al.  Should we use prophylactic tranexamic acid in orthognathic surgery to decrease blood loss? , 2018, International journal of oral and maxillofacial surgery.

[8]  P. Newton,et al.  Development of Consensus Based Best Practice Guidelines for Perioperative Management of Blood Loss in Patients Undergoing Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis , 2018, Spine deformity.

[9]  J. Leveque,et al.  Effect of Tranexamic Acid on Blood Loss, D-Dimer, and Fibrinogen Kinetics in Adult Spinal Deformity Surgery , 2018, The Journal of bone and joint surgery. American volume.

[10]  A. Shetty,et al.  Effectiveness and Safety of Batroxobin, Tranexamic Acid and a Combination in Reduction of Blood Loss in Lumbar Spinal Fusion Surgery , 2018, Spine.

[11]  Lee A. Tan,et al.  Safety of a High-Dose Tranexamic Acid Protocol in Complex Adult Spinal Deformity: Analysis of 100 Consecutive Cases , 2018, Spine deformity.

[12]  H. Hassanzadeh,et al.  Determinants of perioperative transfusion risk in patients with adult spinal deformity. , 2018, Journal of neurosurgery. Spine.

[13]  J. Bible,et al.  Blood-loss Management in Spine Surgery. , 2018, The Journal of the American Academy of Orthopaedic Surgeons.

[14]  Shugang Li,et al.  Can tranexamic acid conserve blood and save operative time in spinal surgeries? A meta-analysis. , 2017, The spine journal : official journal of the North American Spine Society.

[15]  Shugang Li,et al.  A randomized controlled trial on the effects of collagen sponge and topical tranexamic acid in posterior spinal fusion surgeries , 2017, Journal of Orthopaedic Surgery and Research.

[16]  Natalie C. Moreland,et al.  A Randomized Controlled Trial of Low-Dose Tranexamic Acid versus Placebo to Reduce Red Blood Cell Transfusion During Complex Multilevel Spine Fusion Surgery. , 2017, World neurosurgery.

[17]  Shugang Li,et al.  Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery , 2017, Medicine.

[18]  Lorri A. Lee,et al.  Injury and Liability Associated With Spine Surgery , 2017, Journal of neurosurgical anesthesiology.

[19]  Y. Chen,et al.  The efficacy of bipolar sealer on blood loss in spine surgery: a meta-analysis , 2017, European Spine Journal.

[20]  N. Endo,et al.  Administration of tranexamic acid to patients undergoing surgery for adolescent idiopathic scoliosis evokes pain and increases the infusion rate of remifentanil during the surgery , 2017, PloS one.

[21]  J. Bago,et al.  Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trial† , 2017, British journal of anaesthesia.

[22]  T. Jahng,et al.  Effectiveness and Safety of Tranexamic Acid in Spinal Deformity Surgery , 2016, Journal of Korean Neurosurgical Society.

[23]  O. Matsuzaki,et al.  Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin. , 2016, Thrombosis research.

[24]  F. Bilotta,et al.  Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence , 2016, Anesthesia and analgesia.

[25]  Hong Zhao,et al.  Using tranexamic acid soaked absorbable gelatin sponge following complex posterior lumbar spine surgery: A randomized control trial , 2016, Clinical Neurology and Neurosurgery.

[26]  T. Chinachoti,et al.  Two Doses of Tranexamic Acid Reduce Blood Transfusion in Complex Spine Surgery: A Prospective Randomized Study , 2015, Spine.

[27]  F. Schwab,et al.  Antifibrinolytics Reduce Blood Loss in Adult Spinal Deformity Surgery: A Prospective, Randomized Controlled Trial , 2015, Spine.

[28]  Yan Wang,et al.  Radiologic and clinical outcomes comparison between single- and two-level pedicle subtraction osteotomies in correcting ankylosing spondylitis kyphosis. , 2015, The spine journal : official journal of the North American Spine Society.

[29]  Mark Loeb,et al.  Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments , 2014, BMC Medical Research Methodology.

[30]  Z. Hua,et al.  Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial , 2013, European Spine Journal.

[31]  A. Guha,et al.  Comparison of aprotinin and tranexamic acid in adult scoliosis correction surgery , 2012, European Spine Journal.

[32]  A. Wilke,et al.  Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study , 2011, BMC surgery.

[33]  M. Farrokhi,et al.  Efficacy of Prophylactic Low Dose of Tranexamic Acid in Spinal Fixation Surgery: A Randomized Clinical Trial , 2011, Journal of neurosurgical anesthesiology.

[34]  Diane G. Cope,et al.  Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias. , 2011, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[35]  L. Lenke,et al.  Can We Safely Reduce Blood Loss During Lumbar Pedicle Subtraction Osteotomy Procedures Using Tranexamic Acid or Aprotinin?: A Comparative Study With Controls , 2010, Spine.

[36]  Jinwei Xie,et al.  Comparison of three routes of administration of tranexamic acid in primary unilateral total knee arthroplasty: Analysis of a national database. , 2019, Thrombosis research.