Subtle Changes in Residue 77 of the γ Subunit of α1β2γ2 GABAA Receptors Drastically Alter the Affinity for Ligands of the Benzodiazepine Binding Site*
暂无分享,去创建一个
Erwin Sigel | E. Sigel | R. Baur | Roland Baur | A. Buhr | Andreas Buhr
[1] H. Wieland,et al. Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. , 1994, Journal of medicinal chemistry.
[2] H. Okayama,et al. High-efficiency transformation of mammalian cells by plasmid DNA. , 1987, Molecular and cellular biology.
[3] I. Martin,et al. The Major Site of Photoaffinity Labeling of the -Aminobutyric Acid Type A Receptor by HFlunitrazepam Is Histidine 102 of the Subunit (*) , 1996, The Journal of Biological Chemistry.
[4] R. Harris,et al. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. , 1994, The Journal of biological chemistry.
[5] S. Russek,et al. From ion currents to genomic analysis: Recent advances in GABAA receptor research , 1995, Synapse.
[6] E. Sigel,et al. A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. , 1983, The Journal of biological chemistry.
[7] Gerhard Trube,et al. The effect of subunit composition of rat brain GABAA receptors on channel function , 1990, Neuron.
[8] P. Supavilai,et al. Distinction of benzodiazepine agonists from antagonists by photoaffinity labelling of benzodiazepine receptors in vitro , 1982, Neuroscience Letters.
[9] E. Sigel,et al. Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[10] E. Sigel,et al. Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. , 1992, The EMBO journal.
[11] P. Seeburg,et al. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology , 1989, Nature.
[12] R. Olsen,et al. Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit. , 1994, The Journal of biological chemistry.
[13] P. Seeburg,et al. Functional Expression of GABAA Chloride Channels and Benzodiazepine Binding Sites in Baculovirus Infected Insect Cells , 1992, Bio/Technology.
[14] D. Burt,et al. GABAA receptor subtypes: from pharmacology to molecular biology , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] A. Draguhn,et al. GABAA-receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands , 1990 .
[16] N. Nayeem,et al. Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis , 1994, Journal of neurochemistry.
[17] F. Stephenson,et al. The gamma 2 subunit is an integral component of the gamma-aminobutyric acidA receptor but the alpha 1 polypeptide is the principal site of the agonist benzodiazepine photoaffinity labeling reaction. , 1990, The Journal of biological chemistry.
[18] E. Sigel,et al. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site. , 1996, Molecular pharmacology.
[19] W. Sieghart,et al. Irreversible Binding of [3H]Flunitrazepam to Different Proteins in Various Brain Regions , 1983, Journal of neurochemistry.
[20] Y. Cheng,et al. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. , 1973, Biochemical pharmacology.
[21] P. Seeburg,et al. Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family , 1987, Nature.
[22] P. Seeburg,et al. γ‐Aminobutyric AcidA Receptor α5‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology , 1990 .
[23] P. Seeburg,et al. Benzodiazepine-induced motor impairment linked to point mutation in cerebeilar GABAA receptor , 1993, Nature.
[24] W. Wisden,et al. The third gamma subunit of the gamma-aminobutyric acid type A receptor family. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[25] I. Martin,et al. Molecular neurobiology of the GABAA receptor. , 1994, International review of neurobiology.
[26] A. Aguzzi,et al. Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[27] P. Seeburg,et al. Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors. , 1994, Molecular pharmacology.
[28] M. Brownstein,et al. Cloning and expression of a novel rat GABAA receptor , 1989, FEBS letters.
[29] E. Sigel. Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid. , 1987, The Journal of physiology.
[30] R. Olsen,et al. GABAA receptor channels. , 1994, Annual review of neuroscience.
[31] J. Sikela,et al. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. , 1993, Molecular pharmacology.
[32] P. Seeburg,et al. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. , 1992, The Journal of biological chemistry.
[33] W. Sieghart,et al. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. , 1995, Pharmacological reviews.
[34] C. Faure-Halley,et al. Expression and properties of recombinant α1β2γ2 and α5β2γ2 forms of the rat GABAA receptor , 1993 .
[35] E. Sigel,et al. Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[36] P. Seeburg,et al. gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[37] Z Dembic,et al. Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. , 1991, Proceedings of the National Academy of Sciences of the United States of America.