Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma

A 76‐year‐old Japanese woman had noticed an asymptomatic and palpable mass in her left parotid gland region for 20 years. The tumor had showed rapid growth during the last two months. Therefore, the tumor was clinically suspected of being a malignant tumor and was surgically resected. A histopathological examination revealed that the tumor consisted of two different histopathological neoplastic components accompanied by hyalinized fibrosis at the center of the tumor. The two‐neoplastic components were squamous cell carcinoma and salivary duct carcinoma. The tumor was suspected to be a carcinoma ex pleomorphic adenoma after considering the clinical course and the histopathological findings, such as hyalinized fibrosis at the center of the tumor. There was no evidence of recurrence at 30 months after the surgical resection.

[1]  E. Abemayor,et al.  Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. , 2015, Oral surgery, oral medicine, oral pathology and oral radiology.

[2]  Seungwon Kim,et al.  Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: A comparative study from a single tertiary center , 2015, Head & neck.

[3]  B. Perez-Ordonez,et al.  An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions , 2013, Histopathology.

[4]  T. Negri,et al.  Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). , 2009, Oral oncology.

[5]  H. Hiratsuka,et al.  Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. , 2009, International journal of oral and maxillofacial surgery.

[6]  M. Caversaccio,et al.  Carcinoma ex pleomorphic adenoma: Diagnostic difficulty and outcome , 2008, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  H. Uryu,et al.  Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland , 2008, Pathology international.

[8]  M. Kanematsu,et al.  Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: Radiologic-Pathologic Correlation with MR Imaging Including Diffusion-Weighted Imaging , 2008, American Journal of Neuroradiology.

[9]  F. Facchetti,et al.  Amplification and overexpression of HER2/neu gene and HER2/neu protein in salivary duct carcinoma of the parotid gland. , 2007, Archives of otolaryngology--head & neck surgery.

[10]  A. Sendelhofert,et al.  Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53 , 2007, Histopathology.

[11]  D. Macpherson,et al.  Multiple synchronous and metachronous neoplasms of the parotid gland: the Chichester experience. , 2006, The British journal of oral & maxillofacial surgery.

[12]  L. Thompson.  World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours , 2006, Ear, nose, & throat journal.

[13]  J. Soames,et al.  Carcinoma Ex Benign Pleomorphic Adenoma of the Parotid Gland , 2005, Plastic and reconstructive surgery.

[14]  K. Yamazaki,et al.  Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochemical, and p53 Gene Alteration Analysis , 2002, Modern Pathology.

[15]  K. Olsen,et al.  Carcinoma ex pleomorphic adenoma: A clinicopathologic review , 2001, Head & neck.

[16]  M. Mukai,et al.  A hybrid carcinoma: adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland , 1997, Virchows Archiv.

[17]  D. Gnepp,et al.  Synchronous tumors arising in a single major salivary gland , 1989, Cancer.

[18]  K. Donath,et al.  [A pathological sub-classification of carcinoma of salivary gland pleomorphic adenoma. An analysis of 38 cases (author's transl)]. , 1977, HNO.

[19]  C. Antonescu,et al.  Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts. , 2015, Human pathology.

[20]  Gnepp Dr.  Malignant mixed tumors of the salivary glands: a review. , 1993 .

[21]  D. Gnepp.  Malignant mixed tumors of the salivary glands: a review. , 1993, Pathology annual.

[22]  S. Nozaki.  Tumors of the Major Salivary Glands , 1981 .