Perfluoroalkyl and polyfluoroalkyl substances in consumer products

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are used in a wide range of products of all day life. Due to their toxicological potential, an emerging focus is directed towards their exposure to humans. This study investigated the PFAS load of consumer products in a broad perspective. Perfluoroalkyl sulfonic acids (C4, C6–C8, C10-PFSA), carboxylic acids (C4–C14-PFCA) and fluorotelomer alcohols (4:2, 6:2; 8:2 and 10:2 FTOH) were analysed in 115 random samples of consumer products including textiles (outdoor materials), carpets, cleaning and impregnating agents, leather samples, baking and sandwich papers, paper baking forms and ski waxes. PFCA and PFSA were analysed by HPLC-MS/MS, whereas FTOH were detected by GC/CI-MS. Consumer products such as cleaning agents or some baking and sandwich papers show low or negligible PFSA and PFCA contents. On the other hand, high PFAS levels were identified in ski waxes (up to about 2000 μg/kg PFOA), leather samples (up to about 200 μg/kg PFBA and 120 μg/kg PFBS), outdoor textiles (up to 19 μg/m2 PFOA) and some other baking papers (up to 15 μg/m2 PFOA). Moreover, some test samples like carpet and leather samples and outdoor materials exceeded the EU regulatory threshold value for PFOS (1 μg/m2). A diverse mixture of PFASs can be found in consumer products for all fields of daily use in varying concentrations. This study proves the importance of screening and monitoring of consumer products for PFAS loads and the necessity for an action to regulate the use of PFASs, especially PFOA, in consumer products.

[1]  Lei Zhang,et al.  The occurrence of perfluorinated alkyl compounds in human milk from different regions of China. , 2010, Environment international.

[2]  Yawei Wang,et al.  Occurrence of perfluorinated compounds in fish from Qinghai-Tibetan Plateau. , 2010, Environment international.

[3]  M. Clara,et al.  Emissions of perfluorinated alkylated substances (PFAS) from point sources--identification of relevant branches. , 2008, Water science and technology : a journal of the International Association on Water Pollution Research.

[4]  T J Wallington,et al.  Formation of C7F15COOH (PFOA) and other perfluorocarboxylic acids during the atmospheric oxidation of 8:2 fluorotelomer alcohol. , 2006, Environmental science & technology.

[5]  E. Kissa,et al.  Fluorinated Surfactants and Repellents , 2001 .

[6]  Martina Bartel-Steinbach,et al.  Survey of patterns, levels, and trends of perfluorinated compounds in aquatic organisms and bird eggs from representative German ecosystems , 2011, Environmental science and pollution research international.

[7]  M. Schlummer,et al.  Detection of fluorotelomer alcohols in indoor environments and their relevance for human exposure. , 2013, Environment international.

[8]  James Franklin,et al.  Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins , 2011, Integrated environmental assessment and management.

[9]  T. Church,et al.  Analysis of a homologous series of perfluorocarboxylates from American Red Cross adult blood donors, 2000-2001 and 2006. , 2011, Environmental science & technology.

[10]  Morton A Barlaz,et al.  Quantitative determination of fluorochemicals in municipal landfill leachates. , 2011, Chemosphere.

[11]  R. Dietz,et al.  Increasing perfluoroalkyl contaminants in east greenland polar bears (Ursus maritimus): a new toxic threat to the Arctic bears. , 2008, Environmental science & technology.

[12]  Urs Berger,et al.  Riverine discharge of perfluorinated carboxylates from the European continent. , 2007, Environmental science & technology.

[13]  C. Guerranti,et al.  Pilot study on levels of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in selected foodstuffs and human milk from Italy. , 2013, Food chemistry.

[14]  M. Schlummer,et al.  Impact of industrial production and packaging processes on the concentration of per- and polyfluorinated compounds in milk and dairy products. , 2013, Journal of agricultural and food chemistry.

[15]  A. Kondo,et al.  Discharge of perfluorinated compounds from rivers and their influence on the coastal seas of Hyogo prefecture, Japan. , 2014, Environmental pollution.

[16]  T. Nakano,et al.  Perfluorinated compounds in sediment samples from the wastewater canal of Pančevo (Serbia) industrial area. , 2013, Chemosphere.

[17]  L. Hardell,et al.  Case-control study on perfluorinated alkyl acids (PFAAs) and the risk of prostate cancer. , 2014, Environment international.

[18]  Konrad Hungerbühler,et al.  Estimating Consumer Exposure to PFOS and PFOA , 2008, Risk analysis : an official publication of the Society for Risk Analysis.

[19]  D. Herzke,et al.  Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway - a pilot study. , 2012, Chemosphere.

[20]  Young-Min Kang,et al.  Wastewater treatment plants (WWTPs)-derived national discharge loads of perfluorinated compounds (PFCs). , 2012, Journal of hazardous materials.

[21]  E. Bonefeld‐Jørgensen,et al.  Perfluorinated compounds affect the function of sex hormone receptors , 2013, Environmental Science and Pollution Research.

[22]  Martin Schlabach,et al.  Investigation on per- and polyfluorinated compounds in paired samples of house dust and indoor air from Norwegian homes. , 2011, Environmental science & technology.

[23]  A. Calafat,et al.  Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008. , 2011, Environmental science & technology.

[24]  P. Korytar,et al.  Distribution of perfluorinated compounds in aquatic systems in the Netherlands. , 2010, Environmental science & technology.

[25]  D. Schrenk,et al.  Opinion of the Scientific Panel on Contaminants in the Food chain on perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts , 2008 .

[26]  Timothy J Wallington,et al.  Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids. , 2004, Environmental science & technology.

[27]  A. Pession,et al.  Perfluoroalkyl substances in human milk: a first survey in Italy. , 2013, Environment international.

[28]  K. Hungerbühler,et al.  Atmospheric fate of poly- and perfluorinated alkyl substances (PFASs): II. Emission source strength in summer in Zurich, Switzerland. , 2012, Environmental pollution.

[29]  C. Schröter-Kermani,et al.  Levels and trends of industrial chemicals (PCBs, PFCs, PBDEs) in archived herring gull eggs from German coastal regions , 2012, Environmental Sciences Europe.

[30]  J. Domingo,et al.  Health risks of dietary exposure to perfluorinated compounds. , 2012, Environment international.

[31]  J. Parsons,et al.  Persistence of perfluoroalkylated substances in closed bottle tests with municipal sewage sludge , 2008, Environmental science and pollution research international.

[32]  A. Tjønneland,et al.  Determinants of plasma PFOA and PFOS levels among 652 Danish men. , 2011, Environmental science & technology.

[33]  Marta Schuhmacher,et al.  PBPK modeling for PFOS and PFOA: validation with human experimental data. , 2014, Toxicology letters.

[34]  A. Calafat,et al.  Polyfluorinated compounds in dust from homes, offices, and vehicles as predictors of concentrations in office workers' serum. , 2013, Environment international.

[35]  M. Wilhelm,et al.  Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany. , 2010, International journal of hygiene and environmental health.

[36]  Merle M. Plassmann,et al.  Perfluoroalkyl carboxylic acids with up to 22 carbon atoms in snow and soil samples from a ski area. , 2013, Chemosphere.

[37]  Scott A Mabury,et al.  Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids. , 2004, Environmental science & technology.

[38]  L. S. Haug,et al.  Per- and polyfluorinated compounds in house dust and indoor air from northern Norway - a pilot study. , 2011, Chemosphere.

[39]  J. Sabín,et al.  A study of the interaction between proteins and fully-fluorinated and fully-hydrogenated surfactants by ζ-potential measurements , 2004 .

[40]  Wei Zhang,et al.  Proteomic analysis of male zebrafish livers chronically exposed to perfluorononanoic acid. , 2012, Environment international.

[41]  Scott A Mabury,et al.  Significant residual fluorinated alcohols present in various fluorinated materials. , 2006, Environmental science & technology.

[42]  Fumio Okada,et al.  Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy , 2004, Environmental health perspectives.

[43]  L. S. Haug,et al.  Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation. , 2010, Environmental science & technology.

[44]  Siyuan Peng,et al.  An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. , 2013, Journal of pharmaceutical and biomedical analysis.

[45]  H. Yoo,et al.  Concentrations, distribution, and persistence of perfluoroalkylates in sludge-applied soils near Decatur, Alabama, USA. , 2010, Environmental science & technology.

[46]  A. Calafat,et al.  Polyfluorinated compounds in serum linked to indoor air in office environments. , 2012, Environmental science & technology.

[47]  Ian T Cousins,et al.  Comparative assessment of the global fate and transport pathways of long-chain perfluorocarboxylic acids (PFCAs) and perfluorocarboxylates (PFCs) emitted from direct sources. , 2009, Environmental science & technology.

[48]  Karl-Werner Schramm,et al.  Poly- and perfluorinated compounds in household consumer products , 2010 .

[49]  H. Westberg,et al.  A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax. , 2010, Environmental science & technology.

[50]  K. Hungerbühler,et al.  Atmospheric fate of poly- and perfluorinated alkyl substances (PFASs): I. Day-night patterns of air concentrations in summer in Zurich, Switzerland. , 2012, Environmental pollution.

[51]  D. Savitz,et al.  Serum Perfluorinated Compound Concentration and Attention Deficit/Hyperactivity Disorder in Children 5–18 Years of Age , 2011, Environmental health perspectives.

[52]  Ralf Ebinghaus,et al.  Polyfluorinated compounds in residential and nonresidential indoor air. , 2010, Environmental science & technology.

[53]  Bert van Bavel,et al.  Identification and pattern of perfluorooctane sulfonate (PFOS) isomers in human serum and plasma. , 2007, Environment international.

[54]  Urs Berger,et al.  Trends of perfluorinated alkyl substances in herring gull eggs from two coastal colonies in northern Norway: 1983-2003. , 2007, Environmental science & technology.

[55]  B. Le Bizec,et al.  Occurrence of perfluorinated alkylated substances in breast milk of French women and relation with socio-demographical and clinical parameters: results of the ELFE pilot study. , 2013, Chemosphere.

[56]  Haizhen Yang,et al.  Occurrence of perfluoroalkyl compounds in surface waters from the North Pacific to the Arctic Ocean. , 2012, Environmental science & technology.

[57]  Ian Stirling,et al.  Rapid response of Arctic ringed seals to changes in perfluoroalkyl production. , 2007, Environmental science & technology.

[58]  Xenia Trier,et al.  Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging , 2011, Environmental science and pollution research international.

[59]  S. Mabury,et al.  Is indirect exposure a significant contributor to the burden of perfluorinated acids observed in humans? , 2011, Environmental science & technology.

[60]  U. Berger,et al.  Tissue distribution of perfluorinated surfactants in common guillemot (Uria aalge) from the Baltic Sea. , 2008, Environmental science & technology.

[61]  L. S. Haug,et al.  Occupational exposure to airborne perfluorinated compounds during professional ski waxing. , 2010, Environmental science & technology.

[62]  M. Rosen,et al.  Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes. , 2013, Toxicology.

[63]  H. Viberg,et al.  A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain. , 2013, Neurotoxicology.

[64]  R. Ebinghaus,et al.  Temporal trends and pattern of polyfluoroalkyl compounds in Tawny Owl (Strix aluco) eggs from Norway, 1986-2009. , 2011, Environmental science & technology.

[65]  R. Ebinghaus,et al.  Urban versus remote air concentrations of fluorotelomer alcohols and other polyfluorinated alkyl substances in Germany. , 2007, Environmental science & technology.

[66]  Bert van Bavel,et al.  Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans. , 2013, Environment international.

[67]  Ian T Cousins,et al.  Sources, fate and transport of perfluorocarboxylates. , 2006, Environmental science & technology.

[68]  Kevin C Jones,et al.  Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe. , 2007, Journal of environmental monitoring : JEM.

[69]  Harvey J Clewell,et al.  Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles. , 2005, Environmental science & technology.

[70]  M. Vrijheid,et al.  Effects of persistent organic pollutants on the developing respiratory and immune systems: a systematic review. , 2013, Environment international.

[71]  Jinxia Liu,et al.  Microbial degradation of polyfluoroalkyl chemicals in the environment: a review. , 2013, Environment international.

[72]  B. Koletzko,et al.  Pre- and postnatal exposure to perfluorinated compounds (PFCs). , 2010, Environmental science & technology.

[73]  H. Håkansson,et al.  Cumulative health risk assessment of 17 perfluoroalkylated and polyfluoroalkylated substances (PFASs) in the Swedish population. , 2013, Environment international.

[74]  D. Costopoulou,et al.  Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. , 2014, Chemosphere.

[75]  Roland Weber,et al.  PFOS and PFC releases and associated pollution from a PFC production plant in Minnesota (USA) , 2013, Environmental Science and Pollution Research.

[76]  M. Wilhelm,et al.  Perfluorinated compounds in fish and blood of anglers at Lake Möhne, Sauerland area, Germany. , 2011, Environmental science & technology.

[77]  J. Cravedi,et al.  SCIENTIFIC OPINION Marine biotoxins in shellfish - Domoic acid 1 Scientific Opinion of the Panel on Contaminants in the Food Chain , 2009 .

[78]  J. M. Keller,et al.  Spatial and temporal trends of perfluorinated compounds in Beluga Whales (Delphinapterus leucas) from Alaska. , 2011, Environmental science & technology.

[79]  J. Baker,et al.  Perfluorinated compounds in the surface waters of Puget Sound, Washington and Clayoquot and Barkley Sounds, British Columbia. , 2014, Marine pollution bulletin.