Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.

[1]  P. Swietach,et al.  Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production , 2022, British Journal of Cancer.

[2]  R. Gillies,et al.  Proton export upregulates aerobic glycolysis , 2022, BMC Biology.

[3]  J. Pouysségur,et al.  'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives. , 2022, Seminars in cancer biology.

[4]  Marc L. Mendillo,et al.  The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis. , 2022, Molecular cell.

[5]  W. Bodmer,et al.  GMMchi: gene expression clustering using Gaussian mixture modeling , 2022, bioRxiv.

[6]  D. Langley,et al.  PROTAC targeted protein degraders: the past is prologue , 2022, Nature Reviews Drug Discovery.

[7]  S. Pedersen,et al.  Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets , 2021, Cancer and Metastasis Reviews.

[8]  P. Swietach,et al.  What do cellular responses to acidity tell us about cancer? , 2021, Cancer and Metastasis Reviews.

[9]  T. Salo,et al.  SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes , 2021, Cellular and Molecular Life Sciences.

[10]  P. Swietach,et al.  Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays , 2021, Chemosensors.

[11]  K. Mikoshiba,et al.  Both IRBIT and long-IRBIT bind to and coordinately regulate Cl−/HCO3− exchanger AE2 activity through modulating the lysosomal degradation of AE2 , 2020, Scientific Reports.

[12]  Carolyn R. Bertozzi,et al.  Lysosome-targeting chimaeras for degradation of extracellular proteins , 2020, Nature.

[13]  H. Freeze,et al.  Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells. , 2020, Cancer discovery.

[14]  Maohui Luo,et al.  Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target , 2019, Scientific Reports.

[15]  S. Pedersen,et al.  The Acidic Tumor Microenvironment as a Driver of Cancer. , 2019, Annual review of physiology.

[16]  C. Dang,et al.  mTOR Senses Intracellular pH through Lysosome Dispersion from RHEB. , 2019, BioEssays : news and reviews in molecular, cellular and developmental biology.

[17]  D. Barber,et al.  Intracellular pH dynamics and charge-changing somatic mutations in cancer , 2019, Cancer and Metastasis Reviews.

[18]  Pawel Swietach,et al.  Evidence-based guidelines for controlling pH in mammalian live-cell culture systems , 2019, Communications Biology.

[19]  P. Swietach What is pH regulation, and why do cancer cells need it? , 2019, Cancer and Metastasis Reviews.

[20]  Xingdong Zhou,et al.  Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion , 2018, Autophagy.

[21]  D. Welsh,et al.  Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR , 2018, Cell.

[22]  S. Pedersen,et al.  The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells , 2018, Cell cycle.

[23]  O. Feron,et al.  Tumour acidosis: from the passenger to the driver's seat , 2017, Nature Reviews Cancer.

[24]  Zachary A. Szpiech,et al.  Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins , 2017, Science Signaling.

[25]  W. Xia,et al.  Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR/p70S6K1 signaling , 2017, Scientific Reports.

[26]  N. Demartines,et al.  Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors , 2016, Molecular Cancer.

[27]  M. Yan,et al.  Expression of AE1/p16 promoted degradation of AE2 in gastric cancer cells , 2016, BMC Cancer.

[28]  A. Harris,et al.  Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth. , 2016, Cancer research.

[29]  R. Gillies,et al.  Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane , 2015, Nature Communications.

[30]  Y. Liu,et al.  Structure and Function of SLC4 Family HCO3- Transporters , 2015, Front. Physiol..

[31]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[32]  M. Romero,et al.  The SLC4 family of bicarbonate (HCO₃⁻) transporters. , 2013, Molecular aspects of medicine.

[33]  Robert J Gillies,et al.  Acidity generated by the tumor microenvironment drives local invasion. , 2013, Cancer research.

[34]  Trent Su,et al.  Histone acetylation regulates intracellular pH. , 2013, Molecular cell.

[35]  Bonnie F. Sloane,et al.  Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. , 2012, Cancer research.

[36]  A. Halestrap,et al.  The monocarboxylate transporter family—Role and regulation , 2012, IUBMB life.

[37]  Matthew P. Jacobson,et al.  Dysregulated pH: a perfect storm for cancer progression , 2011, Nature Reviews Cancer.

[38]  Karen K. Y. Lam,et al.  Regulation of mTORC1 Signaling by pH , 2011, PloS one.

[39]  R. Vaughan-Jones,et al.  Dual Role of CO2/HCO3− Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths* , 2011, The Journal of Biological Chemistry.

[40]  M. J. Clague,et al.  Ubiquitin: Same Molecule, Different Degradation Pathways , 2010, Cell.

[41]  Robert J. Gillies,et al.  Tumor pH and Its Measurement , 2010, The Journal of Nuclear Medicine.

[42]  Joel s. Brown,et al.  The evolutionary dynamics of cancer prevention , 2010, Nature Reviews Cancer.

[43]  Valerio Embrione,et al.  A Gene Network Regulating Lysosomal Biogenesis and Function , 2009, Science.

[44]  D. Barber,et al.  Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding , 2008, The Journal of cell biology.

[45]  Pernille R. Jensen,et al.  Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate , 2008, Nature.

[46]  E. T. Gawlinski,et al.  Acid-mediated tumor invasion: a multidisciplinary study. , 2006, Cancer research.

[47]  Adrian L Harris,et al.  Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. , 2006, Cancer research.

[48]  S. Alper Molecular physiology of SLC4 anion exchangers , 2006, Experimental physiology.

[49]  W. Boron,et al.  Regulation of intracellular pH. , 2004, Advances in physiology education.

[50]  L. Huc,et al.  Alterations of intracellular pH homeostasis in apoptosis: origins and roles , 2004, Cell Death and Differentiation.

[51]  S. Kellokumpu,et al.  The AE2 anion exchanger is necessary for the structural integrity of the Golgi apparatus in mammalian cells , 2004, FEBS letters.

[52]  R. Kühne,et al.  Solution Structure of Human Cofilin , 2004, Journal of Biological Chemistry.

[53]  D. Barber,et al.  Na-H Exchange-dependent Increase in Intracellular pH Times G2/M Entry and Transition* , 2003, Journal of Biological Chemistry.

[54]  S. Kellokumpu,et al.  Targeting of the AE2 anion exchanger to the Golgi apparatus is cell type‐dependent and correlates with the expression of Ank195, a Golgi membrane skeletal protein , 2003, FEBS letters.

[55]  Gregory S Karczmar,et al.  MRI of the tumor microenvironment , 2002, Journal of magnetic resonance imaging : JMRI.

[56]  M. Lerman,et al.  Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer. , 2001, Cancer research.

[57]  Roger Y. Tsien,et al.  Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis , 2000, Nature Cell Biology.

[58]  ROGER C. Thomas Bicarbonate and pHi response , 1989, Nature.

[59]  E. Racker,et al.  Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. , 1979, Biochemistry.

[60]  Sergio Grinstein,et al.  Sensors and regulators of intracellular pH , 2010, Nature Reviews Molecular Cell Biology.